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ADRBK1

  • Official Full Name

    adrenergic, beta, receptor kinase 1

  • Overview

    G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization proces
  • Synonyms

    ADRBK1; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; BARK1; GRK2; beta-ARK-1; G-protein coupled receptor kinase 2; BETA-ARK1; FLJ16718;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADRBK1-383H Active Recombinant Human ADRBK1 Protein, GST-tagged Insect Cell GST
Human ADRBK1-1019H Recombinant Human Adrenergic, Beta, Receptor Kinase 1, GST-tagged Sf9 Insect Cell GST
Human ADRBK1-978H Recombinant Human ADRBK1 protein(Met1-Leu689), His&GST-tagged Insect Cells N-His&GST Met1-Leu689
Human ADRBK1-357H Recombinant Human Adrenergic, Beta, Receptor Kinase 1, His-tagged Insect Cell His
Human ADRBK1-9445H Recombinant Human ADRBK1, His-tagged E.coli His 390-689a.a.
Human ADRBK1-152H Recombinant Human ADRBK1 Mammalian Cell His
Human ADRBK1-625HCL Recombinant Human ADRBK1 cell lysate Insect Cell N/A
Human ADRBK1-1562HF Active Recombinant Full Length Human ADRBK1 Protein, GST-tagged Insect (sf21) GST 1-689(end)
Human ADRBK1-2437H-B Recombinant Human ADRBK1 Protein Pre-coupled Magnetic Beads HEK293
Human ADRBK1-2437H Recombinant Human ADRBK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADRBK1-546R Recombinant Rat ADRBK1 Protein Mammalian Cell His
Rat ADRBK1-202R Recombinant Rat ADRBK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADRBK1-202R-B Recombinant Rat ADRBK1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ADRBK1-3006C Recombinant Chicken ADRBK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADRBK1 Related Articles
  • ADRBK1 Related Gene Family

ADRBK1 involved in several pathways and played different roles in them. We selected most pathways ADRBK1 participated on our site, such as Activation of SMO, CXCR4-mediated signaling events, Ca-dependent events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRBK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of SMOBOC;ADRBK1;KIF3A;GAS8;EVC2;CDON;CSNK1A1;IQCE;EFCAB7
CXCR4-mediated signaling eventsJAK2;MAPKAP1;GNA13;CFL1;PAG1;BLK;ADRBK1;CRK;DNM1
Ca-dependent eventsADCY7;PRKAR1AA;ADCY9;ADRBK1
CaM pathwayPRKAR1AA;ADRBK1
Calmodulin induced eventsPRKAR1AA;ADRBK1
Chemokine signaling pathwaySHC3;PLCB4;ARRB1;ELMO1;CCL5;PIK3CB;GNG5;GNG12;GNG4
DAG and IP3 signalingADRBK1;AHCYL1;PRKAR1AA
DAP12 interactionsPEA15;CSF2RA;DUSP9;JAK3;CLEC5A;SPRED2;PTPRA;RASGRP4;PEA15A

ADRBK1 has several biochemical functions, for example, ATP binding, Edg-2 lysophosphatidic acid receptor binding, G-protein coupled receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRBK1 itself. We selected most functions ADRBK1 had, and list some proteins which have the same functions with ADRBK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATP5B;PRPF4BB;ACTR2B;MYH11;ABCC11;SKIV2L2;ERN1;CAMK2B1;EHD2
Edg-2 lysophosphatidic acid receptor binding
G-protein coupled receptor kinase activityGRK7B;RLN1;GRK1;GRK7;GRK6;GRK5;GRK7A;ADRBK2;GRK4
alpha-2A adrenergic receptor bindingAPLP1;ADRA2C;ADRB1;ADRBK1;UCHL1
beta-adrenergic receptor kinase activityADRBK2;GRK6;ADRBK1;GRK5
protein bindingPTPRG;KCNA2;RHBDL1;ASB9;TTF2;DOCK10;GAB1;RPLP1;APBB3
protein kinase activityGUCY2F;MAP3K1;TBCK;PTK6B;STK4;PRKCZ;ACVR2AA;PIK3C3;PDPK1A

ADRBK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRBK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRBK1.

UBC; FPR1; EGFR; HDAC6; GIT1; TUBB; MDM2

Wex, E; Thaler, E; et al. A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLOS ONE 9:-(2014).
Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).
  • Q&As
  • Reviews

Q&As (8)

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Can ADRBK1 inhibitors be used to treat respiratory diseases? 12/19/2022

ADRBK1 inhibitors have shown potential as a treatment for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) in preclinical studies. ADRBK1 is involved in the regulation of airway tone and smooth muscle contraction, and ADRBK1 inhibition has been shown to improve airway function and reduce inflammation in preclinical models of asthma and COPD. However, more research is needed to determine the efficacy and safety of ADRBK1 inhibitors in human clinical trials for these indications.

Are there any genetic mutations that affect ADRBK1 proteins? 05/17/2021

Yes, several genetic mutations have been identified that affect ADRBK1 proteins, leading to functional alterations and disease susceptibility. For example, a common variant in the ADRBK1 gene, known as the ADRBK1 A>G polymorphism, has been associated with increased risk of heart failure, hypertension, and other cardiovascular diseases. Other studies have linked mutations in ADRBK1 with conditions like asthma, diabetes, and Alzheimer's disease, although the exact mechanisms by which these mutations contribute to pathology are not fully understood.

What are the potential risks associated with modulating ADRBK1 activity or expression? 05/27/2020

Like any drug or therapeutic intervention, modulating ADRBK1 activity or expression carries potential risks and side effects. For example, blocking ADRBK1 activity could potentially lead to excessive receptor activation and signaling, causing unintended consequences and potential toxicity. Conversely, enhancing ADRBK1 activity could lead to receptor desensitization and decreased responsiveness to ligands, which could impair normal physiological processes. Therefore, the safety and efficacy of ADRBK1-targeted therapies must be carefully evaluated in preclinical and clinical studies before being implemented in the clinic.

How does ADRBK1 affect the cardiovascular system? 01/03/2020

ADRBK1, also known as beta-adrenergic receptor kinase 1, plays a crucial role in regulating signaling pathways in the cardiovascular system. It is involved in the regulation of cardiac function, blood pressure, and vascular tone. ADRBK1 is responsible for phosphorylating and desensitizing beta-adrenergic receptors, which are involved in the regulation of heart rate, contractility, and vascular tone. ADRBK1 inhibition has been shown to improve cardiac function, reduce blood pressure, and mitigate the effects of heart failure in preclinical studies. However, more research is needed to fully understand the effects of ADRBK1 inhibition on the cardiovascular system and to determine the safety and efficacy of these therapies in human clinical trials.

What research is currently being done on ADRBK1 proteins? 11/20/2019

ADRBK1 proteins continue to be an active area of research, with ongoing investigations exploring their roles in various disease processes and their potential as therapeutic targets. Some current research areas include developing more selective and potent ADRBK1 inhibitors, exploring the effects of ADRBK1 polymorphisms on disease susceptibility and drug response, and investigating the complex signaling pathways that involve ADRBK1 in different tissues and cell types. Additionally, preclinical and clinical studies are continuing to evaluate the safety and efficacy of ADRBK1-targeted therapies in various disease settings.

Are there any ADRBK1 inhibitors currently approved for clinical use? 10/13/2018

There are currently no ADRBK1 inhibitors approved for clinical use. However, several compounds are being developed as potential ADRBK1 inhibitors for use in the treatment of cardiovascular and metabolic diseases, as well as anxiety disorders and cancer. These compounds are in various stages of preclinical and clinical development, and more research is needed to determine their safety and efficacy in human clinical trials.

How are ADRBK1 proteins involved in disease processes? 07/03/2018

Dysregulation of ADRBK1 activity has been implicated in several disease processes, including cardiovascular disease, immune dysfunction, and cancer. In cardiovascular disease, elevated levels of ADRBK1 have been associated with impaired cardiac function, while decreased levels have been linked to hypertension and myocardial infarction. In immune dysfunction, ADRBK1 contributes to the development of inflammatory responses, and increased activity has been observed in conditions like asthma, rheumatoid arthritis, and sepsis. In cancer, ADRBK1 has been shown to promote tumor growth and metastasis.

Are there any drugs that target ADRBK1 proteins? 04/21/2017

Yes, there are several drugs that target ADRBK1 proteins. These include small molecule inhibitors that block ADRBK1 activity and prevent receptor desensitization, as well as compounds that modulate ADRBK1 expression or activity indirectly. Some of these drugs have shown promise in preclinical and clinical studies for treating conditions like heart failure, hypertension, and asthma.

Customer Reviews (4)

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Reviews
04/13/2021

    The bands of proteins in the Western Blotting experiment were very clear

    05/26/2019

      The ADRBK1 protein is of exceptional quality and is precisely what I need for my experimental purposes.

      11/15/2017

        With confidence in the protein's quality and the assistance provided by the supplier, I believe this is the ideal protein to meet my experimental needs.

        02/18/2016

          I am confident that it will provide reliable and consistent results.

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