Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

GRK7

Official Full Name

G protein-coupled receptor kinase 7
Overview

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation.
Synonyms

GRK7; G protein-coupled receptor kinase 7; GPRK7; g protein-coupled receptor kinase GRK7;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Human

Source

HEK293
In Vitro Cell Free System
Insect (sf21)
Insect Cell
Sf21
Sf9 Insect Cell
Wheat Germ

Tag

C
Myc
DDK
GST
His
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GRK7-77HFL	Active Recombinant Full Length Human GRK7 Protein, N-His-tagged	Sf21	His	Full Length	Inquiry
Human	GRK7-1021H	Recombinant Human G Protein-Coupled Receptor Kinase 7, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	GRK7-753HCL	Recombinant Human GRK7 cell lysate		N/A		Inquiry
Human	GRK7-147H	Recombinant Human GRK7 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Human	GRK7-2357H	Recombinant Human GRK7 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	GRK7-5576HF	Recombinant Full Length Human GRK7 Protein, GST-tagged	In Vitro Cell Free System	GST	553 amino acids	Inquiry
Human	GRK7-5360H	Active Recombinant Human GRK7 Protein, GST-tagged	Insect Cell	GST		Inquiry
Human	GRK7-5361H	Recombinant Human GRK7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GRK7-8988HF	Active Recombinant Full Length Human GRK7 Protein, GST-tagged	Insect (sf21)	GST	1-553	Inquiry

GRK7 involved in several pathways and played different roles in them. We selected most pathways GRK7 participated on our site, such as Chemokine signaling pathway, Endocytosis, Inactivation, recovery and regulation of the phototransduction cascade, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chemokine signaling pathway	GRK4;GNGT1;CCR10;JAK2;GNG4;GNB2;CCL4;STAT5B;PIK3CG
Endocytosis	ARPC4L;ACAP2;ARPC5A;HGS;FAM125A;SPG20A;MHC1UXA2;STAM2;SMAP2
Inactivation, recovery and regulation of the phototransduction cascade	METAP1;GNB5A;NMT2;GUCA1E;METAP2;METAP2B;SAGB;CNGA1;RGS9BP
Phototransduction	CALM2;SLC24A1;RCVRNA;CALM;RGS9A;GNB1B;GUCY2F;CALM4;CALM2A
Signal Transduction	ANXA1A;RIT1;HEBP1;ADM2A;NEDD8L;FSTB;SOX6;TAX1BP3;OTULINB
The phototransduction cascade	METAP2B;SAGB;METAP2;PPEF1;NMT1A;RLN1;METAP2A;GUCA1E;NMT1B
Visual phototransduction	METAP2B;LRP12;SAGB;SDR9C7;RLBP1;GUCA1E;RDH10;LRP10;BCO2A
Visual signal transduction: Cones	RDH12;GRK7;ARR3;RLN1;CNGA3

GRK7 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, rhodopsin kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRK7 itself. We selected most functions GRK7 had, and list some proteins which have the same functions with GRK7. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	DNAH5;EGFR;PIM2;KIF20B;ATP2C1;FASTK;CKMT2B;ACTB;MAP4K6
G-protein coupled receptor kinase activity	ADRBK2;GRK7B;ADRBK1;GRK6;RLN1;GRK1B;GRK5;GRK1A;GRK1
rhodopsin kinase activity	GRK1A;GRK1;GRK1B;GRK7B;GRK7;RLN1;GRK4;GRK7A

GRK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRK7.

HSP90AB1

Hudson, NJ; Baker, ML; et al. Sensory Rewiring in an Echolocator: Genome-Wide Modification of Retinogenic and Auditory Genes in the Bat Myotis davidii. G3-GENES GENOMES GENETICS 4:1825-1835(2014).

Tsutsui, K; Tachibanaki, S; et al. Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440:630-634(2013).

GRKs (G Protein-coupled Receptor Kinases)