grm6
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  • Official Full Name
  • glutamate receptor, metabotropic 6
  • Background
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.
  • Synonyms
  • GRM6; glutamate receptor, metabotropic 6; metabotropic glutamate receptor 6; GPRC1F; mGlu6; MGLUR6; CSNB1B; DKFZp686H1993
Cat.#:GRM6-5369HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRM6 Protein, GST-tagged
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Cat.#:GRM6-679HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human GRM6
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Cat.#:Kit-1076Tag:
Source (Host):Species:
Product namep300 Inhibitor Screening Assay Kit (Fluorometric)
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Cat.#:Kit-1336Tag:
Source (Host):Species:
Product namecAMP GRM6 CHO-K1 GPCR Assay Kit
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Involved Pathway

GRM6 involved in several pathways and played different roles in them. We selected most pathways GRM6 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phospholipase D signaling pathway
AKT2; PLCG1; GRM6; PIP5K1A; AGPAT5; DGKZ; PPAP2B; SHC4; PIP5K1C; CXCR1
Neuroactive ligand-receptor interaction
GABRB3; PRSS3; GABRD; TAAR10B; GABRE; GABRA2; PRP2; GNRHR1; ADRB3B; P2RY10
Glutamatergic synapse
HOMER3; PRKCB; GRM8; GRIA3; SLC38A2; GRM4; GRIA1; ITPR1; GRIK4; ITPR3

Protein Function

GRM6 has several biochemical functions, for example, G-protein coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM6 itself. We selected most functions GRM6 had, and list some proteins which have the same functions with GRM6. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled receptor activity
Related Protein OR13A1; TAAR10C; VMN1R40; GPR88; OPN1MW3; TAS2R143; OR12D2; OLFCG2; GPR179; VMN2R26
Function glutamate receptor activity
Related Protein GRM3; GRM2; GRIA1; GRM8; GRM6; GRM7; GRIK5; GRM5; GRM1; GRM4
Function group III metabotropic glutamate receptor activity
Related Protein GRM6; GRM7; GRM6B; GRM8; GRM4; GRM6A
Function protein binding
Related Protein PSMD6; RNF43; TH1L; SFTPC; STIM2; AKAP8L; LCMT1; IMPA2; PDK3; VHL
Function protein homodimerization activity
Related Protein ERN1; GHR; ZBTB1; UBE4A; TERF2; CARD9; MYH9; CBX5; PRDM6; OLIG2