GRN
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Official Full Name
granulin
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Overview
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. -
Synonyms
GRN; granulin; GEP; GP88; PEPI; PGRN; PCDGF; progranulin; Acrogranin; Granulin-1; Granulin G; Granulin-2; Granulin F; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; Granulin A; Granulin C; Granulin D; Granulin E; granulin-epithelin; proepithelin; PC cell-derived growth factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- His|S
- His|T7
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- GRN Related Articles
- GRN Related Research Area
GRN involved in several pathways and played different roles in them. We selected most pathways GRN participated on our site, such as Integrated Breast Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Integrated Breast Cancer Pathway | DHTKD1;CCNB1IP1;APOBEC3G;USP38;NAB1;RPP38;NOXA1;DCAKD;BACH1 |
GRN has several biochemical functions, for example, cytokine activity, growth factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRN itself. We selected most functions GRN had, and list some proteins which have the same functions with GRN. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | HMGB1;CMTM3;TGFB1A;WNT5A;IFNA2;IFNPHI3;LTA;BMP2B;IFNPHI2 |
growth factor activity | TIMP1;VEGFB;HBEGFB;FGF8;GDF2;CSF3;PDGFA;GFER;TYMP |
poly(A) RNA binding | METAP2;MYBBP1A;YWHAG;CS;MBNL1;RCC2;ADARB2;POP1;EPPK1 |
protein binding | RGS2;GOSR2;CLTC;TAGLN2;ADIPOQ;MAGEA3;ANXA10;ITGB4;IFT172 |
GRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRN here. Most of them are supplied by our site. Hope this information will be useful for your research of GRN.
GLRX3; HOXA1; TNFRSF1A; TNFRSF1B; 80125
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.
GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.
Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.
The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.
Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.
GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.
Customer Reviews (3)
Write a reviewThe outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.
Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.
This protein has a short half-life, high clearance rate, and high safety and efficacy.
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