GSDMD
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Official Full Name
gasdermin D
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Overview
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. -
Synonyms
GSDMD; gasdermin D; gasdermin domain containing 1 , GSDMDC1; gasdermin-D; DF5L; FLJ12150; gasdermin domain containing 1; gasdermin domain-containing protein 1; DFNA5L; FKSG10; GSDMDC1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
GSDMD involved in several pathways and played different roles in them. We selected most pathways GSDMD participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GSDMD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
GSDMD has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSDMD itself. We selected most functions GSDMD had, and list some proteins which have the same functions with GSDMD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | C4orf19;RGS2;KRTAP8-1;GNAI1;PRDM14;INPP5K;LTF;TMEM110;MNAT1 |
GSDMD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSDMD here. Most of them are supplied by our site. Hope this information will be useful for your research of GSDMD.
KCTD6; acpA; mdlB5; q7cl54_yerpe
- Q&As
- Reviews
Q&As (5)
Ask a questionStudies have suggested that the expression levels of GSDMD protein may be associated with disease severity and prognosis in certain inflammatory conditions, indicating its potential as a prognostic marker.
Mutations in the GSDMD gene have been associated with autoinflammatory disorders, such as familial Mediterranean fever, which presents with recurrent episodes of fever and inflammation.
Various signaling pathways and post-translational modifications regulate the activity of GSDMD protein, contributing to its involvement in the pathogenesis of inflammatory diseases.
The inflammasome, a multiprotein complex that regulates inflammatory responses, activates GSDMD protein to induce pyroptosis and release of pro-inflammatory cytokines, contributing to the pathogenesis of inflammatory diseases.
Targeting GSDMD protein could lead to the development of diagnostic tools for detecting and monitoring inflammatory diseases, providing valuable insights for patient management.
Customer Reviews (3)
Write a reviewWhether I need to study protein-protein interactions, protein localization, or protein folding, the GSDMD protein consistently delivers precise and meaningful data.
the GSDMD protein's compatibility with various experimental techniques further supports its usability.
One of the standout features of the GSDMD protein is the excellent technical support provided by the manufacturer.
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