gsta4
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  • Official Full Name
  • glutathione S-transferase alpha 4
  • Background
  • Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinsons disease, Alzheimers disease, cataract formation, and atherosclerosis.
  • Synonyms
  • GSTA4; glutathione S-transferase alpha 4; glutathione S transferase A4; glutathione S-transferase A4; DKFZp686D21185; Glutathione S alkyltransferase A4; Glutathione S aralkyltransferase A4; Glutathione S aryltransferase A4; Glutathione S transferase A4 4; Glutathione S transferase alpha 4; Glutathione S-transferase A4-4; Glutathione transferase A4 4; GST class alpha member 4; GST class-alpha member 4; GSTA4 4; GSTA4_HUMAN; GTA4; OTTHUMP00000016624; OTTHUMP00000016625; S (hydroxyalkyl)glutathione lyase A4; glutathione transferase A4-4; glutathione S-aryltransferase A4; glutathione S-alkyltransferase A4; glutathione S-aralkyltransferase A4; S-(hydroxyalkyl)glutathione lyase A4; GSTA4-4
Cat.#:GSTA4-1956HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Glutathione S-transferase Alpha 4, His-tagged
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Cat.#:GSTA4-15844HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTA4, His-tagged
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Cat.#:GSTA4-24HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GSTA4 protein, His-tagged
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Cat.#:GSTA4-27771THTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human GSTA4, GST-tagged
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Cat.#:GSTA4-906HTag:DDK
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human GSTA4 Protein, DDK-tagged
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Cat.#:GSTA4-7327MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GSTA4 Protein
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Cat.#:Gsta4-738MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gsta4 protein, His-tagged
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Cat.#:Gsta4-739RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Gsta4 protein, His & T7-tagged
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Cat.#:GSTA4-572CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus GSTA4 Protein, His-tagged
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Cat.#:GSTA4-1989RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey GSTA4 Protein, His-tagged
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Cat.#:GSTA4-5717HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GSTA4 293 Cell Lysate
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Involved Pathway

GSTA4 involved in several pathways and played different roles in them. We selected most pathways GSTA4 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutathione metabolism
GGT1A; GSR; SMS; GCLM; MGST1.1; G6PD; GSTT2B; GGT5; GSTO2; GSTM1
Metabolism of xenobiotics by cytochrome P
CYP2F2; GSTT2; CBR2; UGT1A1; GSTAL; UGT2A3; UGT1A3; GSTM4; GSTA3; GSTM3
Drug metabolism - cytochrome P
ADH1; FMO3; UGT1A9; GSTP2; MAOA; FMO1; GSTT2; ALDH1A3; AOX3; UGT1A6B
Chemical carcinogenesis
SULT1A4; UGT1A6; GSTA4; CYP3A7; ALDH3B2; ADH1C; CBR1; UGT1A4; ADH1A; UGT1A6A

Protein Function

GSTA4 has several biochemical functions, for example, glutathione transferase activity, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTA4 itself. We selected most functions GSTA4 had, and list some proteins which have the same functions with GSTA4. You can find most of the proteins on our site.
Function
Related Protein
Function glutathione transferase activity
Related Protein MGST3; GSTK1; GSTA3; GSTM7; MGST2; GSTT2; EEF1E1; GSTZ1; GSTM4; GSTP1
Function protein binding
Related Protein TMED10; TECPR2; PPP6C; PKIA; CARD8; C4BP; RBM17; CARHSP1; USO1; ABCF1
Function protein homodimerization activity
Related Protein KCNE2; UXS1; ERBB4; GLIPR2; MAP3K9; MYO7A; ASNSD1; APOA4; PRDX4; TIMM10

Interacting Protein

GSTA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTA4.
GSTA2; C2orf50

GSTA4 Related Articles

Strom, M; Al Nimer, F; et al. Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons. NEUROMOLECULAR MEDICINE 14:15-29(2012).
Yang, YS; Sharma, R; et al. Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling. ACTA BIOCHIMICA POLONICA 50:319-336(2003).