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GSTT1

Official Full Name

glutathione S-transferase theta 1
Overview

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
Synonyms

GSTT1; glutathione S-transferase theta 1; glutathione S-transferase theta-1; EC 2.5.1.18; Glutathione S transferase 5; Glutathione S transferase theta 1; Glutathione transferase T1 1; Glutathione transferase T1-1; GST 5 5; GST CL1; GST class theta 1; GST class-theta-1; GSTT1_HUMAN; OTTHUMP00000198547; OTTHUMP00000198549; EC 2.5.1.18; Glutathione S transferase 5; GST class-theta-1; GSTT1; Glutathione S Transferase theta 1; GST theta 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GSTT1-26091TH	Recombinant Human GSTT1, His-tagged	E.coli	His		Inquiry
Human	GSTT1-2476H	Recombinant Human Glutathione S-transferase Theta 1	E.coli	N/A		Inquiry
Human	GSTT1-180H	Recombinant Human Glutathione S-transferase Theta 1, His-tagged	E.coli	N/A		Inquiry
Human	GSTT1-28121TH	Recombinant Human GSTT1, His-tagged	E.coli	His	240 amino acids	Inquiry
Human	GSTT1-4429H	Recombinant Human GSTT1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GSTT1-908H	Recombinant Human GSTT1 Protein, His-tagged	E.coli	His		Inquiry
Human	GSTT1-13582H	Recombinant Human GSTT1, His-tagged	E.coli	His	1-240a.a.	$319 / 25ug
Human	GSTT1-312HCL	Recombinant Human GSTT1 lysate	HEK293	N/A		Inquiry
Human	GSTT1-3368HF	Recombinant Full Length Human GSTT1 Protein, GST-tagged	In Vitro Cell Free System	GST	240 amino acids	Inquiry
Human	GSTT1-2223H	Recombinant Human GSTT1 Protein, His-tagged	E.coli	N-His	Phe20-Gln229	Inquiry
Mouse	Gstt1-617M	Recombinant Mouse Gstt1 protein, His & T7-tagged	E.coli	His/T7	Leu7~Gln240 (Accession # Q64471)	Inquiry
Mouse	GSTT1-7341M	Recombinant Mouse GSTT1 Protein	Mammalian Cell	His		Inquiry
Mouse	GSTT1-3981M-B	Recombinant Mouse GSTT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	GSTT1-3981M	Recombinant Mouse GSTT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Gstt1-618R	Recombinant Rat Gstt1 protein, His & T7-tagged	E.coli	His/T7	Leu7~Leu231 (Accession # Q01579)	Inquiry
Chicken	GSTT1-6917C	Recombinant Chicken GSTT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GSTT1 Related Articles

GSTT1 involved in several pathways and played different roles in them. We selected most pathways GSTT1 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glutathione metabolism	MGST2;GPX5;GSTM7;GSTM5;PGD;G6PD;GSTM6;ANPEP;GPX7
Metabolism of xenobiotics by cytochrome P	GSTM3;UGT1A6A;ALDH3B1;HSD11B1;ALDH1A3;GSTM2;GSTP1;MGST1.2;GSTT1B
Drug metabolism - cytochrome P	MGST2;GSTM;GSTM1;GSTT2;MAOA;ADH1;GSTM5;AOX3;UGT1A7
Chemical carcinogenesis	UGT1A9;CCBL1;CYP2C55;GSTM2;GSTT2;CCBL2;AKR1C2;ALDH3B2;CYP2C50

GSTT1 has several biochemical functions, for example, glutathione peroxidase activity, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTT1 itself. We selected most functions GSTT1 had, and list some proteins which have the same functions with GSTT1. You can find most of the proteins on our site.

Function	Related Protein
glutathione peroxidase activity	GPX5;GSTT1;GPX6;GPX1A;PRDX6;MGST3;GPX4A;GSTK1;GSTZ1
glutathione transferase activity	GDAP1;GSTT2;GSTM7;GSTO2;EEF1G;GSTP1;GSTAL;GSTZ1;GSTA3

GSTT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTT1.

EGFR

Kekik, C; Yonal, I; et al. THE IMPACT OF DONOR SPECIFIC ANTI-HLA AND ANTI-GSTT1 ANTIBODIES ON THE OUTCOME OF ALLOGENEIC STEM CELL TRANSPLANTATION. TISSUE ANTIGENS 84:56-57(2014).

Aguilera, I; Sousa, JM; et al. Clinical relevance of GSTT1 mismatch in solid organ and hematopoietic stem cell transplantation. HUMAN IMMUNOLOGY 74:1470-1473(2013).