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GZMB

  • Official Full Name

    granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

  • Overview

    Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
  • Synonyms

    GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; C11; CTLA-1; fragmentin 2; fragmentin-2; cathepsin G-like 1; human lymphocyte protein; T-cell serine protease 1-3E; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • NS0
  • Wheat Germ
  • Yeast
  • C
  • His
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GZMB-296H Active Recombinant Human GZMB, His tagged HEK293 His Met 1-Tyr 247
Human GZMB-315H Active Recombinant Human GZMB protein, His-tagged Mammalian cells His
Human GZMB-33H Active Recombinant Human GZMB Protein (19-247aa), C-His tagged Insect Cell C-His 19-247 aa
Human GZMB-01H Active Recombinant Human GZMB protein, His-tagged NS0 His
Human GZMB-191H Recombinant Human GZMB Mammalian Cell His
Human GZMB-35H Recombinant Human GZMB protein, GST-tagged Wheat Germ GST
Human GZMB -158H Recombinant Human GZMB Protein, GST/His-tagged E.coli GST/His
Human GZMB-2634H Recombinant Human GZMB protein, His & T7-tagged E.coli His/T7 Ile21~Tyr247 (Accession # P10144)
Human GZMB-757H Recombinant Human GZMB E.coli N/A
Human GZMB-2944HCL Recombinant Human GZMB cell lysate Human Cell N/A
Human GZMB-3010H Recombinant Human GZMB protein, His-tagged E.coli His 21-247aa
Human GZMB-3093H Recombinant Human GZMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GZMB-3093H-B Recombinant Human GZMB Protein Pre-coupled Magnetic Beads HEK293
Human GZMB-5421H Recombinant Human GZMB protein, His-tagged Yeast His 21-247aa
Human GZMB-680HF Recombinant Full Length Human GZMB Protein, GST-tagged In Vitro Cell Free System GST 247 amino acids
Human GZMB-3248H Recombinant Human GZMB Protein (Ile21-Arg246), N-His tagged E.coli N-His Ile21-Arg246
Human GZMB-3249H Recombinant Human GZMB Protein (Ala18-Tyr247), C-His tagged E.coli C-His Ala18-Tyr247
Mouse Gzmb-1693M Active Recombinant Mouse Granzyme Mouse N/A
Mouse Gzmb-1966M Active Recombinant Mouse Granzyme B, His-tagged Mammalian cells His
Mouse Gzmb-2635M Recombinant Mouse Gzmb protein, His & GST-tagged E.coli His/GST Thr16~Met244
Mouse Gzmb-942M Recombinant Murine Granzyme B Insect Cell N/A
Mouse Gzmb-414M Recombinant Mouse Granzyme B Mammalian cells N/A
Mouse GZMB-7411M Recombinant Mouse GZMB Protein Mammalian Cell His
Mouse Gzmb-4520M Recombinant Mouse Gzmb Protein E.coli N/A
Mouse Gzmb-2516M Recombinant Mouse Gzmb Protein Insect Cell N/A
Mouse Gzmb-5682M Recombinant Mouse Gzmb Protein (Gly19-Ser247), C-His tagged Mammalian cells C-His Gly19-Ser247
Mouse Gzmb-070M Active Recombinant Mouse Gzmb Protein Insect Cell
Mouse Gzmb-4025M-B Recombinant Mouse Gzmb Protein Pre-coupled Magnetic Beads HEK293
Mouse Gzmb-4025M Recombinant Mouse Gzmb Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gzmb-273G Active Recombinant Mouse Gzmb Protein (227 aa) CHO 227
Rat GZMB-2771R Recombinant Rat GZMB Protein Mammalian Cell His
Rat GZMB-35R Recombinant Rat GZMB Protein, His-tagged HEK293 His
Rat GZMB-2425R Recombinant Rat GZMB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GZMB-2425R-B Recombinant Rat GZMB Protein Pre-coupled Magnetic Beads HEK293
Kit-0403 GZMB Activity Fluorometric Assay Kit N/A
Kit-0404 GZMB Assay/Inhibitor Screening Fluorometric Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GZMB Related Articles

GZMB involved in several pathways and played different roles in them. We selected most pathways GZMB participated on our site, such as Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Natural killer cell mediated cytotoxicityIFNB1;FCGR4;LCP2;GM-CSF;IFNA6;IFNA8;ICAM1;NCR1;IFNAR2
Type I diabetes mellitusHLA-DPB1;HLA-DQA1;TNF;CD80;HLA-DMA;H2-AA;GZMB;HLA-C;IL12A
Transcriptional misregulation in cancerHIST1H3D;SIX1;FCGR1A;CD40;ID2;CDK14;KLF3;HIST1H3A;NFKBIZ
AutoiHLA-DQB1;HLA-G;IFNA1;IFNA21;HLA-DOA;HLA-E;IFNA16;IFNA2;IFNA7
ne thyroid diseaseH2-Q10;FASLG;HLA-DRA;IFNA16;HLA-F;TSHB;Ifna15;TPO;IFNA8
Allograft rejectionHLA-DRB1;IL12B;CD80;GZMB;HLA-C;HLA-DPB1;HLA-DPA1;IL12A;H2-Q10
Graft-versus-host diseaseIL6;HLA-F;GZMB;KIR2DL1;HLA-DRB4;HLA-DRB5;HLA-DMA;HLA-B;Il2

GZMB has several biochemical functions, for example, protein binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMB itself. We selected most functions GZMB had, and list some proteins which have the same functions with GZMB. You can find most of the proteins on our site.

Function Related Protein
protein bindingTMPRSS4;ARMC2;RPGRIP1;TTR;KPNA1;KNG1;ADSS;HDAC2;GNAI3
serine-type endopeptidase activityPRSS27;LTF;TMPRSS4B;PRTN3;TMPRSS11E;F12;C1S;ELANE;PRSS41
serine-type peptidase activityC1R;KLK5;TMPRSS13B;KLK4;ELA3L;OVCH2;PROCA;KLK1B16;HPN

GZMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMB here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMB.

SRGN; FN1; DBP; ELANE; PRF1; EEA1

Mrizak, D; Martin, N; et al. Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 107:-(2015).
Metkar, SS; Marchioretto, M; et al. Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes. CELL DEATH AND DIFFERENTIATION 22:74-85(2015).
  • Q&As
  • Reviews

Q&As (5)

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What are some potential future applications of GZMB in medicine? 02/05/2020

GZMB may be used in the development of targeted therapies for viral infections and various immune-related disorders.

How is GZMB protein clinically relevant in cancer treatment? 07/28/2018

GZMB can be used in cancer immunotherapy to target and eliminate cancer cells.

What are the challenges in using GZMB in cancer immunotherapy? 09/14/2016

One challenge is to ensure that GZMB selectively targets cancer cells without causing harm to healthy cells.

What types of cancer can be targeted using GZMB-based therapies? 07/24/2016

GZMB-based therapies can be used against various types of cancer, including leukemia, lymphoma, and solid tumors.

Can GZMB be used in autoimmune disease treatment? 03/22/2016

GZMB's role in autoimmune diseases is complex. It can contribute to tissue damage in some autoimmune conditions, but its use in treatment is not common.

Customer Reviews (3)

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Reviews
11/01/2020

    I am delighted to express my complete satisfaction with the quality of GZMB protein, as it precisely suits my experimental requirements.

    08/29/2017

      Their knowledgeable team has been readily available to address any concerns or queries, providing effective solutions and guidance whenever needed.

      07/28/2017

        I have full confidence in the GZMB protein and the exceptional support provided by the manufacturer, making it my top recommendation for researchers seeking a high-quality protein for their experimental needs.

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