GZMB
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Official Full Name
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
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Overview
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008] -
Synonyms
GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; granzyme B; C11; CTLA-1; fragmentin 2; fragmentin-2; cathepsin G-like 1; human lymphocyte protein; T-cell serine protease 1-3E; cytotoxic serine protease B; cytotoxic T-lymphocyte proteinase 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Mouse
- NS0
- Wheat Germ
- Yeast
- C
- His
- GST
- GST|His
- His (Fc)
- Avi
- His|GST
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- GZMB Related Articles
GZMB involved in several pathways and played different roles in them. We selected most pathways GZMB participated on our site, such as Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with GZMB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Natural killer cell mediated cytotoxicity | IFNB1;FCGR4;LCP2;GM-CSF;IFNA6;IFNA8;ICAM1;NCR1;IFNAR2 |
Type I diabetes mellitus | HLA-DPB1;HLA-DQA1;TNF;CD80;HLA-DMA;H2-AA;GZMB;HLA-C;IL12A |
Transcriptional misregulation in cancer | HIST1H3D;SIX1;FCGR1A;CD40;ID2;CDK14;KLF3;HIST1H3A;NFKBIZ |
Autoi | HLA-DQB1;HLA-G;IFNA1;IFNA21;HLA-DOA;HLA-E;IFNA16;IFNA2;IFNA7 |
ne thyroid disease | H2-Q10;FASLG;HLA-DRA;IFNA16;HLA-F;TSHB;Ifna15;TPO;IFNA8 |
Allograft rejection | HLA-DRB1;IL12B;CD80;GZMB;HLA-C;HLA-DPB1;HLA-DPA1;IL12A;H2-Q10 |
Graft-versus-host disease | IL6;HLA-F;GZMB;KIR2DL1;HLA-DRB4;HLA-DRB5;HLA-DMA;HLA-B;Il2 |
GZMB has several biochemical functions, for example, protein binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GZMB itself. We selected most functions GZMB had, and list some proteins which have the same functions with GZMB. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | TMPRSS4;ARMC2;RPGRIP1;TTR;KPNA1;KNG1;ADSS;HDAC2;GNAI3 |
serine-type endopeptidase activity | PRSS27;LTF;TMPRSS4B;PRTN3;TMPRSS11E;F12;C1S;ELANE;PRSS41 |
serine-type peptidase activity | C1R;KLK5;TMPRSS13B;KLK4;ELA3L;OVCH2;PROCA;KLK1B16;HPN |
GZMB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GZMB here. Most of them are supplied by our site. Hope this information will be useful for your research of GZMB.
SRGN; FN1; DBP; ELANE; PRF1; EEA1
- Q&As
- Reviews
Q&As (5)
Ask a questionGZMB may be used in the development of targeted therapies for viral infections and various immune-related disorders.
GZMB can be used in cancer immunotherapy to target and eliminate cancer cells.
One challenge is to ensure that GZMB selectively targets cancer cells without causing harm to healthy cells.
GZMB-based therapies can be used against various types of cancer, including leukemia, lymphoma, and solid tumors.
GZMB's role in autoimmune diseases is complex. It can contribute to tissue damage in some autoimmune conditions, but its use in treatment is not common.
Customer Reviews (3)
Write a reviewI am delighted to express my complete satisfaction with the quality of GZMB protein, as it precisely suits my experimental requirements.
Their knowledgeable team has been readily available to address any concerns or queries, providing effective solutions and guidance whenever needed.
I have full confidence in the GZMB protein and the exceptional support provided by the manufacturer, making it my top recommendation for researchers seeking a high-quality protein for their experimental needs.
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