gabra6
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  • Official Full Name
  • gamma-aminobutyric acid (GABA) A receptor, alpha 6
  • Background
  • GABAA receptor subunit; part of a cerebellar receptor subtype, selective for antagonist of alcohol-induced motor incoordination and ataxia
  • Synonyms
  • GABRA6; gamma-aminobutyric acid (GABA) A receptor, alpha 6; gamma-aminobutyric acid receptor subunit alpha-6; GABA A; GABA A Receptor alpha 6polypeptide; GABA A receptor alpha 6; GABA A receptor subunit alpha 6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABRA 6; Gamma aminobutyric acid A receptor alpha 6; Gamma aminobutyric acid GABA A receptor alpha 6; Gamma aminobutyric acid receptor subunit alpha 6; GBRA6_HUMAN; MGC116903; MGC116904; GABA-A receptor alpha-6 subunit; gamma-aminobutyric acid A receptor, alpha 6; gamma-aminobutyric acidA receptor, alpha 6; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6
Cat.#:GABRA6-4643HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GABRA6 Protein, GST-tagged
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Cat.#:GABRA6-13096HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GABRA6, His-tagged
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Cat.#:GABRA6-6148MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GABRA6 Protein
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Cat.#:GABRA6-2447RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GABRA6 Protein
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Cat.#:GABRA6-6615CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GABRA6
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Involved Pathway

Gabra6 involved in several pathways and played different roles in them. We selected most pathways Gabra6 participated on our site, such as Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gabra6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
GRIA2B; TAAR13D; S1PR5; OPRK1; GRIA4B; ADRB2A; P2RX5; PTH1R; TACR1A; GPR35
Retrograde endocannabinoid signaling
GNAI3; PLCB2; GABRB2; DAGLB; PTGS2; PLCB3; GNG8; GABRB3; GRIA3; PRKCA
GABAergic synapse
GLS; SRC; NSF; GABBR2; GABRR1; GNB4; GABRP; GNAI3; GNG7; SLC12A5
Morphine addiction
GNG8; PRKACA; GABRE; GRK6; GNG4; GABRB2; ADRBK2; PDE4D; PDE1C; GNAI2
Nicotine addiction
GRIN3A; CHRNA6; GABRR3; GABRA5; GRIA3; GRIN3B; GABRR1; GRIN2B; GRIA4; GABRG3

Protein Function

Gabra6 has several biochemical functions, for example, contributes_to GABA-A receptor activity, benzodiazepine receptor activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Gabra6 itself. We selected most functions Gabra6 had, and list some proteins which have the same functions with Gabra6. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to GABA-A receptor activity
Related Protein GABRG2; GABRQ; GABRA4; GABRA3; GABRA5; GABRA2; GABRR2A; GABRG1; GABRA6A; GABRR3A
Function benzodiazepine receptor activity
Related Protein TSPO; GABRA6; GABRG2; GABRA4; GABRA2; GABRA3
Function chloride channel activity
Related Protein CLCA5; SLC26A5; CLCN1; CLCA3; CLIC1; GABRP; GRAP2; CLCA1; APOL1; SLC26A9
Function inhibitory extracellular ligand-gated ion channel activity
Related Protein GABRB2; GABRA6A; GABRG2; GABRA1; GABRA3; GABRA6; GABRA5; GABRG1; GABRA2; GABRA4

Gabra6 Related Articles

Ament, SA; Szelinger, S; et al. Rare variants in neuronal excitability genes influence risk for bipolar disorder. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3576-3581(2015).
Srivastava, S; Cohen, J; et al. A Novel Variant in GABRB2 Associated with Intellectual Disability and Epilepsy. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2914-2921(2014).