GATA4
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Official Full Name
GATA binding protein 4
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Overview
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008] -
Synonyms
GATA4; GATA binding protein 4; ASD2; VSD1; TACHD; transcription factor GATA-4; GATA-binding factor 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
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- Wheat Germ
- Flag
- His
- His (Fc)
- Avi
- His|Myc
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- GATA4 Related Articles
- GATA4 Related Research Area
GATA4 involved in several pathways and played different roles in them. We selected most pathways GATA4 participated on our site, such as cGMP-PKG signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | ATP2B4;ATP1B3;PPP1CA;GUCY1A3;CALM3;NFATC1;PPP1CB;MEF2B;PPP3R2 |
| Thyroid hormone signaling pathway | RHEB;PRKCG;TP53;AKT2;PDPK1;PIK3CG;PIK3R1;HDAC2;HDAC1 |
GATA4 has several biochemical functions, for example, DNA binding, NFAT protein binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA4 itself. We selected most functions GATA4 had, and list some proteins which have the same functions with GATA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | DNAJC1;ZEB1B;HIF1AL2;CREB1B;ZNF726;ABL1;ZSCAN4C;ZFP580;HIVEP3 |
| NFAT protein binding | GATA4;SPI1;MAPK14;FOXP3;PPARA;SFPI1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | MIXL1;ZNF253;FOXI1;ZFP746;TLX1;RUNX2;SIX4;EP300;JUND |
| RNA polymerase II regulatory region sequence-specific DNA binding | PCGF6;NFIL3;MEF2C;ATF4B1;ZGLP1;ZSCAN2;MYOD1;ESRRG;ZNF8 |
| RNA polymerase II transcription factor binding | TEAD3;KDM1A;CREBBP;NFATC1;GFI1B;GATA4;GATA1A;CHST13;PITX2 |
| activating transcription factor binding | PRDM16;GATA4;MEF2A;PPARG;HDAC7A;EP300;ATOH8;MEF2D;HDAC7 |
| chromatin binding | CBX1;CBX5;ATXN7;ORC1L;RING1;UBTF;EBF2;NFATC3;WACA |
| co-SMAD binding | CITED1;SMAD2;GATA4;SMAD3;USP9X;TGIF1;FOXH1;TRIM33;SMAD6 |
| enhancer sequence-specific DNA binding | YY1;HMGB2;KLF7B;GATA2;FOXN4;SOX11;KLF6A;GATA5;XBP1 |
| protein binding | CD22;GOLGA1;PKN2;ASGR2;TUT1;LDHD;KRT79;CARD11;FAM82A2 |
| protein kinase binding | SHC1;RB1CC1;ADRA2A;PAK2;SPRED2;PRKAG1;TCF7L2;ITGB2;MEF2A |
| sequence-specific DNA binding | PBX1B;NKX2.7;NFIL3-5;FOXN2B;RAB11FIP4A;HOXA6;CHES1;NR2F6;DBPA |
| transcription coactivator activity | SUPT7L;JUNBB;RNF4;TAF6L;TBPL1;NR1H4;MTF1;TUBB3;RARA |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | SRY;PURA;HIF1A;GATA5;CEBPA;NKX2;HNF4A;PTH;NR1H4 |
| transcription factor activity, RNA polymerase II transcription factor binding | ATF2;YAP1;NACC2;LHX2;MAMSTR;GTF2E1;SMAD4;HIF1A;TWIST2 |
| contributes_to transcription factor activity, sequence-specific DNA binding | SOX19A;GATA4;SMAD3;HNRNPAB;VDRB;SOX19B;VDRA;NKX2;TAF12 |
| transcription factor binding | TFDP1;KDM1A;DDIT3;KEAP1;LCOR;TCF12;H2-AB1;HES2;CXXC5 |
| transcription regulatory region DNA binding | BASP1;SERPINB1A;TNF;SMAD7;MLL1;TP53;HOXA13;XBP1;GLI1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MYOG;STAG2;FOXF1;MAFK;TRPS1;FOXC1;MAFBA;MAFG;MAF |
| zinc ion binding | TRIM35-20;ZDHHC16A;HDAC6;UBR7;NR6A1;TRIM71;TAB3;MSRB3;LMX1BB |
GATA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA4.
KLF13
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- Reviews
Q&As (5)
Ask a questionGATA4 is localized in the nucleus.
WDR3 interacts with GATA4.
GATA4 expression is upregulated in nasopharyngeal carcinoma tissues and cell lines, promoting the proliferation and metastatic ability of nasopharyngeal carcinoma cells.
Overexpression of GATA4 increases the expression of the anti-apoptotic protein B-cell lymphoma factor 2, which is involved in ventricular remodeling.
GATA4 has been associated with studies of liver cancer, breast cancer, and heart disease.
Customer Reviews (3)
Write a reviewThe technician analyzed my experimental process in detail and offered many constructive suggestions.
High protein concentrations were received and the desired experimental results were obtained.
Customer service was patient and careful, solved all kinds of problems for me.
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