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GLDC

  • Official Full Name

    glycine dehydrogenase (decarboxylating)

  • Overview

    Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
  • Synonyms

    GLDC; glycine dehydrogenase (decarboxylating); glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase [decarboxylating], mitochondrial; GCSP; glycine cleavage system protein P; glycine deca;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GLDC-394H Recombinant Human GLDC Mammalian Cell His
Human GLDC-13294H Recombinant Human GLDC, His-tagged E.coli His 675-1020a.a.
Human GLDC-4950H Recombinant Human GLDC Protein, GST-tagged Wheat Germ GST
Human GLDC-3039H Recombinant Human GLDC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GLDC-492H Recombinant Human GLDC Protein, His-tagged E.coli His Thr81~Asp268
Human GLDC-3039H-B Recombinant Human GLDC Protein Pre-coupled Magnetic Beads HEK293
Mouse GLDC-6397M Recombinant Mouse GLDC Protein Mammalian Cell His
Mouse GLDC-3591M Recombinant Mouse GLDC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GLDC-3591M-B Recombinant Mouse GLDC Protein Pre-coupled Magnetic Beads HEK293
Mouse Gldc-494M Recombinant Mouse Gldc Protein, His-tagged E.coli His Thr521~Phe761
Zebrafish GLDC-9957Z Recombinant Zebrafish GLDC Mammalian Cell His
Chicken GLDC-5895C Recombinant Chicken GLDC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GLDC Related Articles

GLDC involved in several pathways and played different roles in them. We selected most pathways GLDC participated on our site, such as Glycine, serine and threonine metabolism, Glyoxylate and dicarboxylate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GLDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycine, serine and threonine metabolismCTH;DMGDH;MAOB;GRHPRB;AGXTA;PGAM1B;CHDH;AOC3;SDSL
Glyoxylate and dicarboxylate metabolismAGXTA;GRHPR;ACAT2;GLYCTK;HAO1;AMT;AGXTB;CS;SHMT2
Metabolic pathwaysST6GALNAC1;NME2;POLR3K;B3GALT6;TDO2A;LIPCA;CYP1A;ALG10;AMPD3
Carbon metabolismGLUD2;ADH5;MTHFR;ME1;HADHA;PGAM1;TKTB;GOT2;GPT2L

GLDC has several biochemical functions, for example, electron carrier activity, glycine binding, glycine dehydrogenase (decarboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GLDC itself. We selected most functions GLDC had, and list some proteins which have the same functions with GLDC. You can find most of the proteins on our site.

Function Related Protein
electron carrier activityNQO2;LOXL2;AKR1C4;GPX2;PRKRA;ACOX3;CIAPIN1;ACADS;GRXCR1
glycine bindingGLDC;SIX2A;GRIN3B;GRIN1;GLRA4B;GNMT;GRIN3A;GLRA1;SRR
glycine dehydrogenase (decarboxylating) activity
lyase activityALDOAA;FH1;IRG1L;THNSL2;CTHL;POLL;GC2;PDXDC1;THA1

GLDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLDC here. Most of them are supplied by our site. Hope this information will be useful for your research of GLDC.

TNIP3; adhB; vacB; q9wmx2-pro_0000037550; ICT1; ULK2

Martinez-Jacobo, L; Ortiz-Lopez, R; et al. Clinical and molecular delineation of duplication 9p24.3q21.11 in a patient with psychotic behavior. GENE 560:124-127(2015).
Kim, HM; Jung, WH; et al. Site-specific metabolic phenotypes in metastatic breast cancer. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
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