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GLDN

  • Official Full Name

    gliomedin

  • Overview

    Gliomedin is a member of the collagen superfamily, it is a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin provides a glial cue for the formation of peripheral nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes of ranvier. Eliminating the expression of gliomedin or the addition of a soluble extracellular domain of neurofascin to myelinating cultures abolishes node formation. Gliomedin is expressed in the PNS nodes of ranvier, but not in the CNS nodes of ranvier. Gliomedin also displays high expression in murine and human hepatocellular carcinomas (HCC). Its restricted expression in normal tissues and unique early upregulation during tumor development make it an excellent candidate as a new clinical marker of HCC.
  • Synonyms

    GLDN; gliomedin; CLOM; COLM; CRGL2; CRG-L2; UNC-112; collomin; colmedin;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GLDN-734H Recombinant Human GLDN protein(Met1-Gln427), hFc-tagged HEK293 N-hFc Met1-Gln427
Human GLDN-1671H Recombinant Human GLDN Protein, GST-tagged Wheat Germ GST
Human GLDN-985H Recombinant Human GLDN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GLDN-1252H Recombinant Human GLDN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GLDN-4951H Recombinant Human GLDN Protein Wheat Germ N/A
Human GLDN-5316HF Recombinant Full Length Human GLDN Protein In Vitro Cell Free System 66 amino acids
Human GLDN-985H-B Recombinant Human GLDN Protein Pre-coupled Magnetic Beads HEK293
Human GLDN-328HFL Recombinant Full Length Human GLDN Protein, C-Flag-tagged Mammalian cells Flag
Mouse GLDN-6398M Recombinant Mouse GLDN Protein Mammalian Cell His
Mouse GLDN-3592M Recombinant Mouse GLDN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GLDN-3592M-B Recombinant Mouse GLDN Protein Pre-coupled Magnetic Beads HEK293
Mouse Gldn-3222M Recombinant Mouse Gldn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GLDN-2560R Recombinant Rat GLDN Protein Mammalian Cell His
Rat GLDN-2216R Recombinant Rat GLDN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GLDN-2216R-B Recombinant Rat GLDN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GLDN-5024Z Recombinant Zebrafish GLDN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GLDN Related Articles

GLDN involved in several pathways and played different roles in them. We selected most pathways GLDN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with GLDN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

GLDN has several biochemical functions, for example, protein binding, protein binding involved in heterotypic cell-cell adhesion. Some of the functions are cooperated with other proteins, some of the functions could acted by GLDN itself. We selected most functions GLDN had, and list some proteins which have the same functions with GLDN. You can find most of the proteins on our site.

Function Related Protein
protein bindingRBM15B;CAV3;SNX3;UBE2I;FAM161A;SEPT1;SYMPK;ITGB7;CIDEB
protein binding involved in heterotypic cell-cell adhesionNFASC;GLDN;NRCAM

GLDN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GLDN here. Most of them are supplied by our site. Hope this information will be useful for your research of GLDN.

Kharade, SS; McBride, MJ; et al. Flavobacterium johnsoniae PorV Is Required for Secretion of a Subset of Proteins Targeted to the Type IX Secretion System. JOURNAL OF BACTERIOLOGY 197:147-158(2015).
Han, HJ; Kursula, P; et al. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:1536-1539(2014).
  • Q&As
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