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PYGB

  • Official Full Name

    phosphorylase, glycogen; brain

  • Overview

    Glycogen phosphorylase isoenzyme BB (abbreviation: GPBB) is an isoenzyme of glycogen phosphorylase. This isoform of the enzyme exists in cardiac (heart) and brain tissue.The enzyme is one of the new cardiac markers which are discussed to improve early diagnosis in acute coronary syndrome. A rapid rise in blood levels can be seen in myocardial infarction and unstable angina.
  • Synonyms

    Glycogen Phosphorylase Isoenzyme BB; GPBB; brain form; Brain glycogen phosphorylase; Glycogen phosphorylase; Glycogen phosphorylase B; Glycogen phosphorylase brain form; MGC9213; Phosphorylase glycogen brain; PYGB; PYGB_HUMAN; phosphorylase, glycogen; brain; glycogen phosphorylase, brain form; OTTHUMP00000030488; EC 2.4.1.1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • Heart
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PYGB-26787TH Recombinant Human PYGB E.coli N/A
Human PYGB-7817H Recombinant Human PYGB protein, His & T7-tagged E.coli His/T7 Pro477~Glu731 (Accession # P11216)
Human PYGB-2087H Recombinant Human PYGB, GST-tagged E.coli GST C-term-300aa
Human PYGB-1449HCL Recombinant Human PYGB cell lysate N/A
Human PYGB-2857H Recombinant Human PYGB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PYGB-1653HFL Recombinant Full Length Human PYGB Protein, C-Flag-tagged Mammalian cells Flag
Human PYGB-366H Recombinant Human Glycogen Phosphorylase B E.coli N/A
Human PYGB-3174H Recombinant Human PYGB Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PYGB-01H Recombinant Human PYGB Protein, His-tagged E.coli His
Human PYGB-1818H Recombinant Human PYGB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PYGB-1818H-B Recombinant Human PYGB Protein Pre-coupled Magnetic Beads HEK293
Human PYGB-03H Native Human PYGB Protein Heart
Human PYGB-6127H Recombinant Human PYGB Protein (Pro477-Glu731), N-His tagged E.coli N-His Pro477-Glu731
Human PYGB-5259H Recombinant Human PYGB protein, GST-tagged E.coli GST 6-843aa
Human PYGB-12H Recombinant Human PYGB Protein, N-His-tagged E. coli N-His Val650 - Asp843
Mouse Pygb-451M Recombinant Mouse Pygb Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque PYGB-3722R Recombinant Rhesus monkey PYGB Protein, His-tagged Mammalian Cell His
Rhesus Macaque PYGB-3539R-B Recombinant Rhesus Macaque PYGB Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PYGB-3539R Recombinant Rhesus Macaque PYGB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PYGB-12075Z Recombinant Zebrafish PYGB Mammalian Cell His
Chicken PYGB-2714C Recombinant Chicken PYGB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PYGB Related Articles

PYGB involved in several pathways and played different roles in them. We selected most pathways PYGB participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Starch and sucrose metabolismAMY2A4;UGP2B;G6PCA.1;UGT1A7;PYGB;UGT1A9;GPI;GPIA;HKDC1
Metabolic pathwaysRRM2;NNMT;GBGT1L4;RPE;HADHAA;POLR3D;RIMKLA;DPYS;PTGS1
Insulin signaling pathwayCALM2A;FOXO1B;PRKCZ;PCK1;MAPK3;PIK3R3;ARAF;MAP2K1;CBL
Insulin resistancePRKAG1;PPP1CAA;RPS6KB2;RPS6KA1;PIK3R2;GYS2;PRKCB;RPS6KA3B;PRKCE

PYGB has several biochemical functions, for example, carbohydrate binding, drug binding, glycogen phosphorylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGB itself. We selected most functions PYGB had, and list some proteins which have the same functions with PYGB. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingKLRC1;GALNT1;LGALS9L1;CLEC4M;CD209B;KLRF1;CD72;CLEC19A;CD55
drug bindingGPR30;HTR2C;TYMS;PYGB;ADRB2;DHODH;P2RX2;PDE2A;PDE10A
glycogen phosphorylase activityPYGMA;PYGM;PYGMB;PYGB;PYGL
protein bindingAAK1;ZNF26;SENP7;NOC4L;TMCO6;SOCS7;TMEM31;SHMT2;ATP1A1
protein homodimerization activityGNB2L1;COQ9;TCF4;SLC24A6;HMGCS1;DEM1;HES1;GALE;C1QB
pyridoxal phosphate bindingSRR;ACCS;PYGM;THNSL2;PDXDC1;GOT1;ABAT;SPTLC2;GOT2B

PYGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGB here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGB.

PYGL; SIAH1; 6319953; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ere_dna; LRRK2; Prkci; Tnpo1; Tsc1

Terashima, M; Fujita, Y; et al. KIAA1199 interacts with glycogen phosphorylase kinase beta-subunit (PHKB) to promote glycogen breakdown and cancer cell survival. ONCOTARGET 5:7040-7050(2014).
Das, A; Durrant, D; et al. Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice POTENTIAL ROLE OF ATTENUATED OXIDATIVE STRESS AND ALTERED CONTRACTILE PROTEIN EXPRESSION. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4145-4160(2014).
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