Glo1
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Official Full Name
glyoxalase I
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Overview
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione.Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. -
Synonyms
GLO1; glyoxalase I; lactoylglutathione lyase; GLOD1; glyoxalase domain containing 1; Aldoketomutase; Glx I; GLYI; Ketone aldehyde mutase; Ketone-aldehyde mutase; Lactoyl glutathione lyase; LGUL_HUMAN; Methylglyoxalase; S D lactoylglutathione methylglyoxal lyase; S-D-lactoylglutathione methylglyoxal lyase; OTTHUMP00000016339;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Met|His
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Glo1 Related Articles
Glo1 involved in several pathways and played different roles in them. We selected most pathways Glo1 participated on our site, such as Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Glo1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pyruvate metabolism | LDHAL6A;PKM;DLDH;GRHPRA;PKMB;ALDH3A2;LDHBB;ALDH2.1;ACACA |
Glo1 has several biochemical functions, for example, lactoylglutathione lyase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Glo1 itself. We selected most functions Glo1 had, and list some proteins which have the same functions with Glo1. You can find most of the proteins on our site.
Function | Related Protein |
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lactoylglutathione lyase activity | GLO1;HPDA |
zinc ion binding | XIAP;TRIM31;NR2F1A;C6AST3;CPA4;CA1;MANEA;RFPL4;PHF14 |
Glo1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Glo1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Glo1.
IKBKE; MAP3K13; IKBKG; MAP1LC3B
- Q&As
- Reviews
Q&As (7)
Ask a questionGLO1 is implicated in diabetes and metabolic disorders, influencing glycation end products and insulin signaling.
GLO1 modulates cancer cell growth and spread, affecting tumor development and metastasis.
GLO1 works with the glyoxalase system to regulate cellular detoxification and protect against metabolic stress.
GLO1 expression affects cellular oxidative stress, playing a role in aging and age-related cellular damage.
Genetic variations in GLO1 alter its activity, affecting disease risk and response to metabolic stress.
Changes in GLO1 levels impact neurological function and may contribute to the progression of neurodegenerative diseases.
GLO1 detoxifies methylglyoxal and other aldehydes, preventing cellular damage and maintaining metabolic balance.
Customer Reviews (3)
Write a reviewTimely protein expression optimization; improves our research efficiency.
Accurate protein structural analysis; crucial for our studies.
Dependable antibody validation; boosts our immunoprecipitation studies.
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