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Glo1

  • Official Full Name

    glyoxalase I

  • Overview

    The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione.Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
  • Synonyms

    GLO1; glyoxalase I; lactoylglutathione lyase; GLOD1; glyoxalase domain containing 1; Aldoketomutase; Glx I; GLYI; Ketone aldehyde mutase; Ketone-aldehyde mutase; Lactoyl glutathione lyase; LGUL_HUMAN; Methylglyoxalase; S D lactoylglutathione methylglyoxal lyase; S-D-lactoylglutathione methylglyoxal lyase; OTTHUMP00000016339;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Met|His
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GLO1-574H Active Recombinant Human GLO1 Protein, Met & His-tagged E.coli Met/His Ala2-Met184
Human GLO1-27H Active Recombinant Human GLO1 protein, His-tagged E.coli His
Human GLO1-29068TH Recombinant Human GLO1 E.coli N/A
Human GLO1-125H Recombinant Human GlyoxalaseⅠ E.coli N/A
Human GLO1-13304H Recombinant Human GLO1, GST-tagged E.coli GST 1-184a.a.
Human GLO1-5899HCL Recombinant Human GLO1 293 Cell Lysate HEK293 N/A
Human GLO1-1412HFL Recombinant Full Length Human GLO1 Protein, C-Flag-tagged Mammalian cells Flag
Human GLO1-4966H Recombinant Human GLO1 Protein, GST-tagged Wheat Germ GST
Human GLO1-986H Recombinant Human GLO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GLO1-4020H Recombinant Human GLO1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GLO1-5340HF Recombinant Full Length Human GLO1 Protein, GST-tagged In Vitro Cell Free System GST 184 amino acids
Human GLO1-986H-B Recombinant Human GLO1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Glo1-62M Active Recombinant Mouse Glo1 Protein, His-tagged Insect Cell His
Mouse Glo1-872M Recombinant Mouse Glo1, His tagged E.coli His
Mouse Glo1-437M Recombinant Mouse Glo1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Glo1-7146M Active Recombinant Mouse Glo1 Protein, His-tagged His 1-184
Rat GLO1-2563R Recombinant Rat GLO1 Protein Mammalian Cell His
Rat GLO1-2219R-B Recombinant Rat GLO1 Protein Pre-coupled Magnetic Beads HEK293
Rat GLO1-2219R Recombinant Rat GLO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey GLO1-548C Recombinant Cynomolgus GLO1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GLO1-293C-B Recombinant Cynomolgus Monkey GLO1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GLO1-293C Recombinant Cynomolgus Monkey GLO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GLO1-1869R Recombinant Rhesus monkey GLO1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GLO1-1689R Recombinant Rhesus Macaque GLO1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GLO1-1689R-B Recombinant Rhesus Macaque GLO1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish GLO1-12367Z Recombinant Zebrafish GLO1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Glo1 Related Articles

Glo1 involved in several pathways and played different roles in them. We selected most pathways Glo1 participated on our site, such as Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Glo1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pyruvate metabolismLDHAL6A;PKM;DLDH;GRHPRA;PKMB;ALDH3A2;LDHBB;ALDH2.1;ACACA

Glo1 has several biochemical functions, for example, lactoylglutathione lyase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Glo1 itself. We selected most functions Glo1 had, and list some proteins which have the same functions with Glo1. You can find most of the proteins on our site.

Function Related Protein
lactoylglutathione lyase activityGLO1;HPDA
zinc ion bindingXIAP;TRIM31;NR2F1A;C6AST3;CPA4;CA1;MANEA;RFPL4;PHF14

Glo1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Glo1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Glo1.

IKBKE; MAP3K13; IKBKG; MAP1LC3B

Landeras-Bueno, S; Jorba, N; et al. The Splicing Factor Proline-Glutamine Rich (SFPQ/PSF) Is Involved in Influenza Virus Transcription. PLOS PATHOGENS 7:-(2011).
Kawano, S; Miyaji, M; et al. Regulation of DNA Topoisomerase II beta through RNA-dependent Association with Heterogeneous Nuclear Ribonucleoprotein U (hnRNP U). JOURNAL OF BIOLOGICAL CHEMISTRY 285:26451-26460(2010).
  • Q&As
  • Reviews

Q&As (7)

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What role does GLO1 play in the pathogenesis of diabetes and related metabolic disorders? 02/27/2021

GLO1 is implicated in diabetes and metabolic disorders, influencing glycation end products and insulin signaling.

What are the mechanisms by which GLO1 modulates cancer cell proliferation and metastasis? 09/18/2019

GLO1 modulates cancer cell growth and spread, affecting tumor development and metastasis.

How does GLO1 interact with other components of the glyoxalase system in maintaining cellular homeostasis? 04/10/2019

GLO1 works with the glyoxalase system to regulate cellular detoxification and protect against metabolic stress.

How does GLO1 expression influence cellular oxidative stress and aging? 03/24/2019

GLO1 expression affects cellular oxidative stress, playing a role in aging and age-related cellular damage.

How do genetic variations in the GLO1 gene affect its enzymatic activity and the susceptibility to chronic diseases? 12/25/2018

Genetic variations in GLO1 alter its activity, affecting disease risk and response to metabolic stress.

What is the impact of GLO1 overexpression or deficiency on neurological functions and neurodegenerative diseases? 06/25/2018

Changes in GLO1 levels impact neurological function and may contribute to the progression of neurodegenerative diseases.

How does GLO1 regulate the detoxification of methylglyoxal and other reactive aldehydes in cells? 04/01/2018

GLO1 detoxifies methylglyoxal and other aldehydes, preventing cellular damage and maintaining metabolic balance.

Customer Reviews (3)

Write a review
Reviews
06/28/2022

    Timely protein expression optimization; improves our research efficiency.

    07/20/2020

      Accurate protein structural analysis; crucial for our studies.

      11/05/2019

        Dependable antibody validation; boosts our immunoprecipitation studies.

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