gnai1
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
  • Background
  • Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.
  • Synonyms
  • GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide-binding protein G(i) subunit alpha-1; Gi1 protein alpha subunit; adenylate cyclase-inhibiting G alpha protein; Gi
Cat.#:GNAI1-28963THTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAI1 Protein, His-tagged
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Cat.#:GNAI1-1952HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GNAI1 Protein, MYC/DDK-tagged
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Cat.#:GNAI1-5041HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNAI1 Protein, GST-tagged
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Cat.#:GNAI1-13346HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAI1, GST-tagged
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Cat.#:GNAI1-189HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAI1 protein, GST-tagged
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Cat.#:GNAI1-7014MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNAI1 Protein
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Cat.#:GNAI1-2593RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNAI1 Protein
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Cat.#:GNAI1-6954CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNAI1
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Cat.#:GNAI1-11206ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GNAI1
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Involved Pathway

GNAI1 involved in several pathways and played different roles in them. We selected most pathways GNAI1 participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
ITGAL; AKT2; FGF10; CDH1; FGF16; MLLT4; THBS1; PRKCI; KLK1B4; PDGFC
cGMP-PKG signaling pathway
RHOA; MEF2A; ATP2A1; VDAC1; PDE3B; AGTR1A; Adcy4; KCNJ8; PDE3A; GNAI1
cAMP signaling pathway
FSHB; CNGA2; BRAF; CREB3L3; PAK1; ATP2A2; GHRL; MAPK8; FXYD1; MLLT4
Chemokine signaling pathway
RAC1; PIK3CA; CCL3; RHOA; CCL4L1; PRKCD; CCR6; MAP2K1; CCL4; STAT1
Sphingolipid signaling pathway
BCL2; PIK3CG; MAPK10; MAP3K5; PPP2R2C; MAPK1; RAC3; PIK3R2; LASS1; GNAI3
Adrenergic signaling in cardiomyocytes
CREB3L3A; TPM4B; ADRB3B; CACNB4; MYH7; MYL2; AKT2; PLCB3; PRKACG; CALM1
Axon guidance
COL9A1A; LIMK1; PAK3; EZRA; CNKSR1; SEMA7A; DAB2IPB; EPHB1; EFNA1A; SDCBP
Tight junction
CLDNJ; VAPA; CLDN5B; SPTAN1; MYH8; CLDNE; MYH13; ACTN2; PPP2R2A; CLDN15
Gap junction
TUBB1; PLCB3; GUCY1B3; TJP1; ADCY2B; PDGFC; GNAIA; Pdgfa&Pdgfb; PRKCA; GNA15.4
Platelet activation
AKT1; F2RL3; RAP1B; F2R; PPP1CC; MAPK1; FCGR2A; PRKG1; PIK3CA; PIK3CD
Leukocyte transendothelial migration
PRKCG; MYL10; PLCG1; MYL12A; CDC42; F11R; GNAI3; RHOA; MAPK13; PIK3CG
Circadian entrainment
GNB2; GRIA1; GNG7; ADCYAP1R1; CALM2; GUCY1A3; PLCB3; KCNJ3; PRKG2; GRIN2A
Retrograde endocannabinoid signaling
PRKACG; GABRA2; PRKCG; MAPK10; GABRG2; GRIA2; GABRQ; GNGT1; SLC17A7; ITPR3
Glutamatergic synapse
GRM6; SHANK2; GNB1; PLA2G4A; GLS2; GNG10; GRM8; ITPR1; PRKCG; SLC17A8
Cholinergic synapse
KCNJ2; GNB1; KCNJ14; GNA11; PRKCG; CHRM2; PIK3R1; KRAS; NRAS; GNB4
Serotonergic synapse
ITPR1; PLCB2; NRAS; HTR1B; CYP2C70; GNG8; GNG3; CYP2C38; PRKACG; CYP2D9
GABAergic synapse
GABRA6; GABRA4; GNG5; SLC38A5; GABRQ; GABRG2; GABRG1; GABRR3; GNG11; PRKACB
Dopaminergic synapse
MAPK12; PRKCB; CREB3L2; GNG12; PPP2R3A; GNG5; KCNJ6; SLC6A3; GSK3A; GNAI2
Long-term depression
GNA13; PPP2CA; PPP2R1A; GNAZ; RAF1; PRKCG; CRHR1; MAPK3; GNAQ; KRAS
Progesterone-mediated oocyte maturation
ANAPC13; AKT2; MAPK9; MAPK13; RPS6KAL; MAPK8; ANAPC7; FZR1A; PRKACAB; PLK1
Estrogen signaling pathway
ATF6B; MMP2; PIK3R3; HSPA1B; NOS3; MAPK1; NRAS; KCNJ5; CREB3L2; PIK3CB
Melanogenesis
MITF; Adcy4; CREB1A; FZD9B; CALML5; DCT; FZD7A; PLCB2; PRKACAB; FZD9
Oxytocin signaling pathway
PIK3R5; ACTB; MYLK3; MYLK; MAP2K1; NPR2; MAPK3; PPP3R1; PPP1CC; PIK3CB
Regulation of lipolysis in adipocytes
PRKACA; INS2; PTGS1; PTGS2; PIK3R1; GNAI3; PRKACG; TSHR; PIK3R2; NPY
Renin secretion
REN2; GNAQ; ITPR3; PRKACG; PDE1B; CALM1; CLCA4; AQP1; PPP3CB; ACE
Gastric acid secretion
SLC9A4; GNAI1; PRKACB; ATP1A3; CALM1; ITPR3; ACTB; CA2; KCNK10; CALM3
Parkinsons disease
UQCRQ; NDUFB7; APAF1; NDUFA10; SLC18A1; NDUFA11; NDUFS3; NDUFS6; PRKACA; GNAI1
Cocaine addiction
DRD2; CREB3L3; TH; CREB3L2; NFKB1; CREB3L4; MAOB; ATF6B; SLC18A2; GRIN3B
Morphine addiction
GABRR3; PDE7A; PDE1C; GABRR1; GABRA1; GNB3; GNG3; PDE7B; PDE10A; GNAI3
Alcoholism
SHC4; MAPK3; H2AFX; GNAI3; HIST1H2BE; PKIA; HIST2H2BB; GNB5; HIST1H2AI; HIST4H4
Pertussis
IL1B; GNAI1; C1R; CALM2; CALML3; C1RA; IRF1; IL23; IRAK1; IL1A
Chagas disease (American trypanosomiasis)
GNAI3; RELA; PIK3R1; IL12A; IL6; TGFB3; MYD88; PIK3CG; MAPK9; IFNGR2
Toxoplasmosis
CASP9; PIK3R2; HLA-DQA2; PPIF; IFNGR1; ITGB1; Toxoplasma Gondii Dense Granule Protein 7; LAMB4; TRAF6; PIK3R5
Pathways in cancer
NKX3-1; STAT3; CUL2; MAPK10; FZD2; GNAS; WNT5B; MMP9; MLH1; VEGFB

Protein Function

GNAI1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, GDP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI1 itself. We selected most functions GNAI1 had, and list some proteins which have the same functions with GNAI1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein beta/gamma-subunit complex binding
Related Protein GNAI3; GNAI1; GNAIA; GNA12; GNA11; GNAO1; GNA15.1; GNA13A; GNA14; GNAL
Function G-protein coupled serotonin receptor binding
Related Protein GNAO1; GNAIA; GNAI1; GNAI3; GNAO1A; GNAO1B; GNAZ
Function GDP binding
Related Protein ARL8B; RAB31; RAB7; RAB22A; RAB14; SRP54B; RAN; RAB9A; RAB5C; RRAGC
Function GTP binding
Related Protein EHD2B; TUBB2A; ARL4A; EEF2A.1; RAC1A; RABL5; TUBB6; GBP5; GNAT1; PCK2
Function GTPase activating protein binding
Related Protein TUBB; CDH1; GNAI3; PTBP3; PIN1; FMNL1; TSC1; GNAI1; GNAO1; PLCD1
Function GTPase activity
Related Protein RAB30; GBP1; RAB8B; TBCC; TUBB5; ATL2; RAB1B; GFM1; EEF2A.2; RAB5AB
Function metal ion binding
Related Protein ZFP474; NUDT19; RBM4.2; GALNTL1; MUTYH; NR2F5; Scd2; PRR3; MAT2AL; ATP13A1
Function protein binding
Related Protein COL6A2; ZNF274; ZNF433; B3GAT3; MTAP1B; TUB; NDRG4; CNGA1; SNAP23; TIMM8A
Function signal transducer activity
Related Protein COPS2; PRKCE; ADRB2A; GPR89; TAAR13B; ADORA2AA; OLFR481; IL15RA; OLFR491; TAAR7F

Interacting Protein

GNAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI1.
NUMA1; GPSM2; RGS17; GPSM3; RGS14; RANGAP1; MT1A; GNG2; Cbx1