gnai1
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  • Official Full Name
  • guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
  • Background
  • Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene.
  • Synonyms
  • GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1; guanine nucleotide-binding protein G(i) subunit alpha-1; Gi1 protein alpha subunit; adenylate cyclase-inhibiting G alpha protein; Gi
Cat.#:GNAI1-28963THTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAI1 Protein, His-tagged
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Cat.#:GNAI1-1952HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human GNAI1 Protein, MYC/DDK-tagged
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Cat.#:GNAI1-5041HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GNAI1 Protein, GST-tagged
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Cat.#:GNAI1-13346HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAI1, GST-tagged
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Cat.#:GNAI1-189HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GNAI1 protein, GST-tagged
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Cat.#:GNAI1-7014MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GNAI1 Protein
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Cat.#:GNAI1-2593RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GNAI1 Protein
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Cat.#:GNAI1-6954CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GNAI1
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Cat.#:GNAI1-11206ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish GNAI1
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Involved Pathway

GNAI1 involved in several pathways and played different roles in them. We selected most pathways GNAI1 participated on our site, such as Rap signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
RAP1B; Itgam&Itgb2; BRAF; VASP; PIK3CB; ARAP3; CALM1; ACTG1; PRKCA; PLCB4
cGMP-PKG signaling pathway
MYLK; AKT2; RAF1; ATP1B1; KCNMB4; TRPC6; MYLK3; PIK3R3; MEF2D; PIK3CB
cAMP signaling pathway
PDE4B; PPARA; CALML5; MAPK8; GNAI2; TSHR; TNNI3; AKT2; PPP1CA; RYR2
Chemokine signaling pathway
CXCR5; GNG11; BRAF; VAV2; GRK6; CCL21B; GNB1; CCL4L2; NCF1; CCL6
Sphingolipid signaling pathway
SPHK1; PLCB1; PRKCE; MAPK13; ABCC1; GAB2; MAPK12; SGMS2; SMPD1; ASAH1
Adrenergic signaling in cardiomyocytes
PPP2R1B; GNAIA; ADRB1; ACTC1B; BCL2; MYH7; PIK3R1; SLC14A2; PRKACBA; ADCY3
Axon guidance
RHOC; EPHB4B; COL6A2; PPP3CA; PEA15; ABLIM1; CREB1B; MET; RASA1; DNM2
Tight junction
PRKCA; MPP5A; CLDN15LB; CTNNA3; CLDN7B; MYHZ2; CLDN4; RHOAA; GNAI2; MYL5
Gap junction
PRKACB; PDGFRA; TJP1; MAPK1; DRD2L; DRD2B; GNA11; CDK1; GUCY1A3; TUBB2A
Platelet activation
VASP; MYLK3; ROCK2; PRKACB; ITGB3; P2RX1; PRKG2; FCGR2A; PTGIR; RHOA
Leukocyte transendothelial migration
OCLN; ITGB1; ITGAL; MLLT4; CLDN4; VASP; CLDN2; ARHGAP5; PXN; EZR
Circadian entrainment
CAMK2A; KCNJ6; GNB1; GNG13; KCNJ9; GNAQ; GNG10; GRIA3; GRIN2C; GNAI3
Retrograde endocannabinoid signaling
GABRA3; GABRB1; GNG7; GNGT1; ITPR1; MAPK3; GNGT2; GNG12; GRIA4; DAGLB
Glutamatergic synapse
GLS2; ADRBK2; Adcy4; GNG4; GNG11; GNG5; HOMER1; PRKCA; GRM1; PLA2G4F
Cholinergic synapse
CHRNA3; CHAT; MAPK3; KCNJ2; MAPK1; CHRNA4; KRAS; PIK3R5; KCNJ14; ACHE
Serotonergic synapse
GNG12; PRKCB; PTGS2; GNB3; HTR7; CYP2D26; GNAI1; RAF1; BRAF; TRPC1
GABAergic synapse
NSF; GNAI2; GABARAPL1; GNAI1; GNGT2; PRKCA; HAP1; Adcy4; SLC38A3; GNG11
Dopaminergic synapse
GSK3A; GNB2; CAMK2B; KCNJ9; GRIA3; ITPR1; MAPK11; AKT2; PPP1CA; MAPK8
Long-term depression
GNAO1; PLCB3; PRKCA; PRKCB; ARAF; GRIA1; PLA2G4A; PRKG1; PPP2R1B; PLCB4
Progesterone-mediated oocyte maturation
MAPK9; CDC25C; KRAS; ANAPC1; IGF1RA; MAPK1; CPEB1A; HSP90AA1.2; INS; MAPK12A
Estrogen signaling pathway
HSP90AB1; GNAI3; SP1; HSP90B1; HSPA1B; PLCB1; KCNJ3; GABBR1; HSPA8; FKBP5
Melanogenesis
KIT; GNAI3; GNAS; GNAI1; CALM1A; CALM3; HRASB; POMC; PRKACAA; FZD9
Oxytocin signaling pathway
PPP1CB; CALML3; CACNA2D2; ITPR1; GNAI2; NRAS; CAMKK1; PRKACB; RYR2; MAPK1
Regulation of lipolysis in adipocytes
PTGS2; PIK3CG; PNPLA2; INS1; PLIN1; IRS1; AQP7; FABP4; GNAI3; LOC100328615
Renin secretion
PPP3R1; PRKG2; PPP3CA; AGTR1B; PRKACB; PPP3CB; CALML5; CLCA5; LOC100328615; GNAI3
Gastric acid secretion
GNAS; KCNJ15; ATP4A; KCNK2; CALM4; CAMK2A; Adcy4; CALML3; PLCB2; ITPR1
Parkinsons disease
NDUFA12; NDUFB11; ATP5G3; PPIF; NDUFB1; PRKACG; UCHL1; UBE2L3; SDHD; GNAI1
Cocaine addiction
SLC6A3; CDK5R1; NFKB1; GRIN2C; GNAI1; DLG4; DRD1; PRKACA; GRIN2A; GRM3
Morphine addiction
GABRR3; GNGT2; PDE8B; GNB3; PDE4B; GNAI1; PDE8A; PRKACG; PDE4C; GNG2
Alcoholism
GNG11; HIST1H3G; HIST1H2AM; HIST2H2BE; HIST1H2BN; RAF1; SLC18A2; HIST3H2A; HIST2H2AA2; H2AFY2
Pertussis
C1RA; IL12B; MAPK8; ITGB1; NLRP3; C2; C1S; ITGAM; IL1A; MAPK9
Chagas disease (American trypanosomiasis)
FADD; CD3D; IFNG; IRAK4; PPP2R1B; GNA15; MYD88; ACE; CCL3L1; GNAS
Toxoplasmosis
BCL2L1; TAB2; ITGA6; LAMA4; LDLR; IRAK4; LAMB3; NFKBIA; Toxoplasma Gondii Major Surface Antigen P30; CYCS
Pathways in cancer
LPAR5; PLEKHG5; WNT3A; WNT11; GNGT1; FZD6; GNB1; CASP8; PRKCG; Fgf15

Protein Function

GNAI1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding, G-protein coupled serotonin receptor binding, GDP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI1 itself. We selected most functions GNAI1 had, and list some proteins which have the same functions with GNAI1. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein beta/gamma-subunit complex binding
Related Protein GNAL; GNAO1A; GNAO1B; GNAI3; GNA11B; GNAO1; CETN4; GNAI2A; GNAI1; GNA13B
Function G-protein coupled serotonin receptor binding
Related Protein GNAZ; GNAI3; GNAO1B; GNAO1A; GNAO1; GNAI1; GNAIA
Function GDP binding
Related Protein MIEF1; RAB7; PRPS2; KRAS; ARL3; RAB12; RALB; RAP1B; RHOA; TRIM23
Function GTP binding
Related Protein ARL9; ARL5C; SEPT12; RND3B; TUBA8L2; GSPT2; RHOT1A; RAC1; RND1; ERCC3
Function GTPase activating protein binding
Related Protein TSC1; MEX3B; FMNL1; GAPVD1; PTBP3; GNAI3; GNAO1; RGS14; CDH1; PIN1
Function GTPase activity
Related Protein TUBB6; RAB39BA; RRAGD; RAB9A; ARF4; RAB34A; RAC2; RABL2B; GSPT2; EEF2
Function metal ion binding
Related Protein SRSF7A; ACSM2B; FDX1B; ZFP410; NEK9; LMO4B; ZNF280C; ESR2B; NR2F5; RC3H2
Function protein binding
Related Protein RPL30; SPHK2; TRIM23; SMARCA4; STT3A; RGS20; LACTB2; NAP1L1; APOBEC1; CENPK
Function signal transducer activity
Related Protein OLFR481; CXCR4A; GPR177; MRGPRA7; HTR1AB; STAT2; GHRHRA; RGRB; GNAO1A; OLFR998

Interacting Protein

GNAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI1.
NUMA1; GPSM2; RGS17; GPSM3; RGS14; RANGAP1; MT1A; GNG2; Cbx1