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Gpt2

  • Official Full Name

    glutamic pyruvate transaminase (alanine aminotransferase) 2

  • Overview

    GPT (MIM 138200) and GPT2 (EC 2.6.1.2), also known as alanine transaminases, are pyridoxal enzymes that catalyze the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. By mediating the conversion of these 4 major intermediate metabolites, these transaminases have roles in gluconeogenesis and in amino acid metabolism.
  • Synonyms

    GPT2; glutamic pyruvate transaminase (alanine aminotransferase) 2; alanine aminotransferase 2; ALT2; AAT2; Glutamate pyruvate transaminase 2; Glutamic alanine transaminase 2; Glutamic pyruvic transaminase 2; GPT 2; glutamic--alanine transaminase 2; glutamic--pyruvic transaminase 2; glutamic-pyruvate transaminase 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Antibody
  • Arabidopsis thaliana (Mouse-ear cress)
  • Human
  • Mouse
  • Rat
  • Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Tag
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPT2-23H Active Recombinant Human GPT2 protein, His-tagged E.coli His
Human GPT2-13508H Recombinant Human GPT2, GST-tagged E.coli GST 174-523a.a.
Human ALT2-3249H Recombinant Human ALT2, His-tagged E.coli His 423
Human GPT2-7214H Recombinant Human GPT2, His-tagged E.coli His 1-523aa
Human GPT2-5305H Recombinant Human GPT2 Protein, GST-tagged Wheat Germ GST
Human GPT2-01H Active Recombinant human ALT2/GPT2 Protein, His-tagged E.coli His-Tag 1-523aa
Human GPT2-2774H Recombinant Human GPT2 Protein (Val174-Ala523), N-His tagged E.coli N-His Val174-Ala523
Human GPT2-2235H Recombinant Human GPT2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human GPT2-5574HF Recombinant Full Length Human GPT2 Protein, GST-tagged In Vitro Cell Free System GST 523 amino acids
Human GPT2-1258HFL Recombinant Full Length Human GPT2 Protein, C-Flag-tagged Mammalian cells Flag
Human GPT2-1016H Recombinant Human GPT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GPT2-4295H Recombinant Human GPT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GPT2-1016H-B Recombinant Human GPT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Gpt2-1029M Recombinant Mouse Gpt2 protein, His-tagged E.coli His Lys255~Leu507 (Accession # Q8BGT5)
Mouse GPT2-7229M Recombinant Mouse GPT2 Protein Mammalian Cell His
Mouse GPT2-3900M Recombinant Mouse GPT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gpt2-381M Recombinant Mouse Gpt2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse GPT2-3900M-B Recombinant Mouse GPT2 Protein Pre-coupled Magnetic Beads HEK293
Rat Gpt2-295R Recombinant Rat Gpt2 protein(Met1-Ser522), His-tagged Insect Cells C-His Met1-Ser522
Rat GPT2-720RCL Recombinant Rat GPT2 cell lysate Insect Cell N/A
Rat CAB11548RR Rabbit Anti-Rat GPT2 Monoclonal Antibody Rabbit N/A
Arabidopsis thaliana (Mouse-ear cress) RFL18497AF Recombinant Full Length Arabidopsis Thaliana Glucose-6-Phosphate/Phosphate Translocator 2, Chloroplastic(Gpt2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (69-388)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) RFL27282SF Recombinant Full Length Saccharomyces Cerevisiae Glycerol-3-Phosphate O-Acyltransferase 2(Gpt2) Protein, His-Tagged E.coli expression system His Full Length (1-743)
Zebrafish GPT2-5715Z Recombinant Zebrafish GPT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Gpt2 Related Articles

Gpt2 involved in several pathways and played different roles in them. We selected most pathways Gpt2 participated on our site, such as Arginine biosynthesis, Alanine, aspartate and glutamate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gpt2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine biosynthesisybaS;GOT2B;NOS2A;GLUL;GLSA;GLS;NAGS;GPT2L;NOS3
Alanine, aspartate and glutamate metabolismASL;GLULA;GOT2A;NAT8L;ASPA;GAD1B;GOT2;AGXTB;GLSA
Metabolic pathwaysINPP5B;ST6GALNAC5;POLR3G;GKUP;NDUFA6;HMGCS2;PPAP2C;HSD17B7;ST6GALNAC3
Carbon metabolismIDH2;DLDH;IDH3A;OGDHA;SUCLG1;PFKM;SDHB;GOT1;SUCLG2
-Oxocarboxylic acid metabolismIDH3A;ACY1;GOT2B;IDH1;ACO2;GOT1;GPT2;ACO1;AADAT
Biosynthesis of amino acidsPKMB;TAT;GM5506;CS;PSAT1;PKLR;ALDOCA;ALDOB;PFKM

Gpt2 has several biochemical functions, for example, L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gpt2 itself. We selected most functions Gpt2 had, and list some proteins which have the same functions with Gpt2. You can find most of the proteins on our site.

Function Related Protein
L-alanine:2-oxoglutarate aminotransferase activityGPT2;GPT;GPT2L
pyridoxal phosphate bindingPYGMB;ACCS;GAD1B;GOT1;MOCOS;PDXDC2P;TAT;GPT2;GPT2L

Gpt2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gpt2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gpt2.

BABAM1; USP20; SIRT4

Lindblom, P; Rafter, I; et al. Isoforms of alanine aminotransferases in human tissues and serum - Differential tissue expression using novel antibodies. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 466:66-77(2007).
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