GRB2
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Official Full Name
growth factor receptor-bound protein 2
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Overview
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
GRB2; growth factor receptor-bound protein 2; ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2; HT027; protein Ash; SH2/SH3 adapter GRB2; abundant SRC homology; growth factor receptor-bound protein 3; epidermal growth factor receptor-binding protein GRB2;
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- C
- His
- DYKDDDDK
- Flag
- GST
- GST|His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- No tag
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- GRB2 Related Articles
- GRB2 Related Research Area
- GRB2 Related Signal Pathway
GRB2 involved in several pathways and played different roles in them. We selected most pathways GRB2 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK8A;CACNA1SA;AKT2L;MAPK12A;CACNA2D1A;MAPT;MAPKAPK3;NTRK2B;STMN1 |
| ErbB signaling pathway | PRKCA;GRB2B;ERBB3B;PAK6B;KRAS;MAP2K7;MAP2K1;PLCG1;MAPK9 |
| Ras signaling pathway | GRB2;GRIN2B;GNG5;PIK3R3;IKBKG;INS2;MAPK8;RAB5B;VEGFB |
| Chemokine signaling pathway | XCL2;PF4V1;PIK3CB;CRK;Ccl21a;PIK3R3;NRAS;CCL28;RLN1 |
| FoxO signaling pathway | PRKAB2;FOXO3A;SOS1;TNFSF10;IL7R;AKT2L;CCNB2;MAPK12B;PRKAB1 |
| Phospholipase D signaling pathway | FCER1G;SPHK1;PLA2G4C;KITLG;AVPR1A;GRM8;LPAR6;Adcy4;DGKD |
| PIK-Akt signaling pathway | ITGB6;INSR;FGF18;RAC1;STK11;IGF1;LPAR6;IFNAR2;PDGFD |
| Dorso-ventral axis formation | PIWIL2;GRB2;NOTCH3;NOTCH4;CPEB4;NOTCH1;SPIRE2;NOTCH2;CPEB1A |
| Osteoclast differentiation | LCP2;MAP2K1;NCF1;ACP5;LILRA5;TAB2;LILRA1;IL1B;TRAF6 |
| Focal adhesion | ITGB6;RAC1A;PDGFB;PRKCG;PGF;TNC;PDGFC;AKT2L;GSK3B |
| Gap junction | PDGFAA;ADCY1B;TUBB1;HTR2C;GUCY1B3;SRC;PRKG1A;SOS1;PRKACBA |
| Signaling pathways regulating pluripotency of stem cells | WNT6;WNT3;FGFR3;INHBB;GSK3B;NEUROG1;IGF1R;MEIS1;IGF1 |
| Jak-STAT signaling pathway | CRFB2;IL6;IFNA7;IL28RA;PTPN6;IL6R;CCND2A;IFNA3;RAF1A |
| Natural killer cell mediated cytotoxicity | H60a;PTK2B;ICAM2;IFNA14;PPP3CC;TNF;NCR1;KIR2DS5;Fasl |
| T cell receptor signaling pathway | NFKBIB;CD247;AKT2;CD3E;NFKBIA;PPP3CA;CD8B1;PLCG1;MAPK1 |
| B cell receptor signaling pathway | CD81;CMTM3;PIK3CG;DUSP6;CD19;CARD11;MAP2K1;LCP2A;PIK3R3 |
| Fc epsilon RI signaling pathway | RAF1;RAC3;FCER1G;PLA2G4B;AKT1;MAPK12;PIK3R3;MAP2K3;PLA2G4F |
| Neurotrophin signaling pathway | RPS6KA5;PIK3CB;TP53;NTRK2;KRAS;PIK3R5;PSEN1;SHC2;PLCG2 |
| Insulin signaling pathway | PKLR;SOCS9;PTPN1;TSC1;PHKG2;PIK3R5;INPPL1;RAF1B;FOXO1 |
| GnRH signaling pathway | ADCY1A;MAP3K4;LHBETA1;MAP3K1;GNA11A;HRASB;CALM2;ATF4B1;GNRHR2 |
| Estrogen signaling pathway | PRKACA;MAP2K1;PIK3R5;PIK3CD;SRC;CALML3;CREB3L2;CREB3L1;RAF1 |
| Prolactin signaling pathway | FOXO3;SOCS4;STAT1;GRB2;MAP2K1;PPIB;CSH;STAT3;LHCGR |
| Alcoholism | DRD1;HIST1H2AI;CALM3;HIST3H2BB;GM6026;HIST1H3G;GNG5;HIST1H4C;HIST2H4A |
| Hepatitis C | IFNA6;TBK1;IFN-a;IFNA4;PPP2CB;PPARA;Ifna11;GRB2;TRP53 |
| Hepatitis B | PIK3R2;BAX;DDX58;TGFB1;PIK3R3;MAP3K1;Casp3;IRF7;IFNA13 |
| Pathways in cancer | SUFU;RUNX1T1;FH1;RXRG;LEF1;HRAS;Flt3l;PPARD;MLH1 |
| Viral carcinogenesis | DNAJA3;TRAF1;CCND2;NFKBIA;RAC1;GTF2H1;CDC20;DLG1;STAT3 |
| Proteoglycans in cancer | TWIST1;ITPR1;CD44;HPSE2;RPS6KB2;AKT1;ARHGEF1;GAB1;RRAS |
| MicroRNAs in cancer | FSCN1;ABCC1;IRS2;MARCKS;SERPINB5;PDGFB;PRKCB;CCNE1;SOS1 |
| Renal cell carcinoma | EGLN1;SOS1;EP300;SLC2A1;RAF1;VHL;EGLN2;PDGFB;TGFB3 |
| Endometrial cancer | CDH1;BAD;PDPK1;AXIN2;TCF7L2;GRB2;AKT2;PIK3R1;PIK3R2 |
| Glioma | PLCG2;SHC3;PTEN;PDGFRA;PDGFRB;RAF1;TGFA;AKT2;CCND1 |
| Prostate cancer | IGF1;HSP90AA1;PIK3CB;ACTL6B;INS;PIK3R3;GSK3B;RELA;CREB3L3 |
| Chronic myeloid leukemia | HDAC1;CBL;CBLB;STAT5B;PIK3R2;BRAF;PIK3CG;RAF1;NFKB1 |
| Acute myeloid leukemia | BRAF;STAT3;CHUK;IKBKB;SOS1;PIK3R2;AKT2;PIK3CG;STAT5A |
| Non-small cell lung cancer | PDPK1;RASSF1;HRAS;AKT1;PIK3R2;MAP2K2;GRB2;RAF1;PRKCA |
| Choline metabolism in cancer | CHKB;PIP5K1A;MAPK3;SLC44A1;EGF;AKT1;RPS6KB1;DGKB;TSC1 |
GRB2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB2 itself. We selected most functions GRB2 had, and list some proteins which have the same functions with GRB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | NCF1;SOS1;KHDRBS3;SIRPA;SH3BP5B;SH3BGR;CABYR;MICAL1;ERRFI1 |
| SH3/SH2 adaptor activity | SH2D3C;GRB10;STAM;ARHGAP1;CNTNAP1;SH2B2;ITSN2;NCK2;SH3BGR |
| ephrin receptor binding | EFNA2;NTRK1;Anks1;EFNA3;EFNB2A;EFNB2B;EFNA4;EFNA5B;EFNA1B |
| epidermal growth factor receptor binding | AREG;AGR2;Fert2;MS4A1;FER;PLSCR1;ATXN2;ARF4;SNX4 |
| identical protein binding | SERPINA1D;FNBP1;KCNH2;PFKL;TRIM8;MAPK1IP1;ENTPD2;BCL2L1;KLHL7 |
| insulin receptor substrate binding | PIK3R1;IGF1RB;JAK2;IGF1RA;PTPN11;GRB2;IGF1R;INSRB;PIK3CB |
| neurotrophin TRKA receptor binding | PLCG1;PIK3R1;NGFR;FRS2;SHC1;EFNA5;GRB2 |
| phosphotyrosine binding | MAPK1;STAP1;MAPK3;SAMSN1;CBL;FGR;CBLC;ACP2;ZAP70 |
| poly(A) RNA binding | CSRP1;GFM1;RPL14;NQO1;MRPL40;MRPL21;CALR;MRPS35;ARCN1 |
| protein binding | RPS18;TLDC2;CSF2RA;RPL19;CLASP1;SSX5;RAPGEF6;C16orf5;MAP4K1 |
| protein kinase binding | RHOD;GSTP2;PRKAG2;TICAM1;TRAP1;RPS6;PGAM1;PRKAG3;AP1B1 |
| protein phosphatase binding | PPP6R3;MAP3K5;RPA2;MAP2K7;CDKN1B;CDH2;EIF2AK3;NEK2;DLG4 |
GRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB2.
EGFR
Escalona, Z; Alvarez, B; et al. Molecular characterization of porcine Siglec-10 and analysis of its expression in blood and tissues. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 48:116-123(2015).
Paff, M; Alexandru-Abrams, D; et al. The evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients. HUMAN VACCINES & IMMUNOTHERAPEUTICS 10:3322-3331(2014).
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