GRIN1
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Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 1
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Overview
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] -
Synonyms
GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NR1; MRD8; GluN1; NMDA1; NMDAR1; glutamate receptor ionotropic, NMDA 1; NMD-R1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1;
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- GRIN1 Related Articles
- GRIN1 Related Research Area
GRIN1 involved in several pathways and played different roles in them. We selected most pathways GRIN1 participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | MLLT4;PIK3CD;RRAS2;MRAS;GNGT2;NFKB1;Kitl;SOS1;MAP2K1 |
| Rap signaling pathway | INS;PRKCG;FGF19;ITGB3;MAPK12;MAP2K1;SRC;FLT1;ANGPT2 |
| Calcium signaling pathway | HTR5AL;CYSLTR1;NOS2B;ITPKC;SPHK1;NOS2;PLCD1;PHKG1B;TRHR |
| cAMP signaling pathway | CNGA1;ATP1B2;PRKACA;ATP1A1;GRIN2A;Adcy4;GLP1R;ATP1B1;ACOX1 |
| Neuroactive ligand-receptor interaction | GRIK2;GPR50;NPY2R;CHRNA10;GABRD;GNRHR1;DRD7;HRH2;GRM5 |
| Circadian entrainment | GUCY1B3;GRIN2B;GNAO1;GNG13;PRKCA;PRKG2;FOS;KCNJ3;PRKG1 |
| Long-term potentiation | PRKCB;PLCB4;GRIN1;CALML5;ARAF;GNAQ;KRAS;PPP3CB;MAP2K2 |
| Glutamatergic synapse | GRIA4;HOMER3;GRIN3B;GRIK3;GRIN2A;GNAI3;SLC17A7;PPP3CA;PRKCB |
| Alzheimers disease | NAE1;Atp5g2;GRIN1;COX6C;COX7A2L;NDUFB8;IL1B2;GRIN2B;IL1B |
| Amyotrophic lateral sclerosis (ALS) | DAXX;CASP1;GRIN2C;CAT;TNFRSF1B;SLC1A2;MAP2K6;GRIA1;DERL1 |
| Huntingtons disease | NDUFS6;mt-Atp8;UQCR11;SDHA;POLR2G;NDUFV3;Atp5g2;UQCRFS1;ATP5C1 |
| Cocaine addiction | GRIN2D;GNAI1;GRIA2;GRM2;CREB5;CREB3L2;FOSB;CREB3L4;MAOA |
| Nicotine addiction | GABRG1;GRIN2B;GABRP;GABRR2;GRIN1;GABRB1;CHRNA6;GRIA2;GABRE |
| Alcoholism | HIST1H2BN;HIST1H2AN;GNB5;HIST2H3C1;HIST1H2AJ;GNAO1;HIST2H4;HIST1H4N;ADORA2B |
GRIN1 has several biochemical functions, for example, contributes_to NMDA glutamate receptor activity, contributes_to calcium channel activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN1 itself. We selected most functions GRIN1 had, and list some proteins which have the same functions with GRIN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to NMDA glutamate receptor activity | GRIN1;PTK2B;GRIN3A;GRIN2A |
| contributes_to calcium channel activity | GRIN2A;GRIN1;GRIN3B |
| calcium ion binding | SPTAN1;S100A10B;PCDH2G10;S100A1;PCDH2G2;MYL3;DGKB;PVALB2;RHOT2 |
| calmodulin binding | MAP6D1;C2orf62;MKNK1;MYLK2;KCNN4;CDK5RAP2;ADD3;CAMK2A;OBSCN |
| enzyme binding | PHKG1;PTPN1;NOTCH3;AKT1;AXIN1;RPS3;HSPA2;CREB1;SUPT5H |
| extracellular-glutamate-gated ion channel activity | GRIN1A;GRIK2;GRIN3B;GRIN2B;GRIA1;GRIK3;GRIA2B;GRIN1B;GRIA4A |
| glutamate binding | GCLC;GRIN2A;GAD2;CPS1;GRIK1;SLC1A1;GRIN1;GRM7;SLC1A3 |
| glutamate receptor binding | PLCG1;SYNDIG1;GRIN1;CAMK2A;GRIN2A |
| glycine binding | GLRA1;ALAS2;GRIN3A;GRIN3B;GSS;GRIN1;GNMT;SRR;GLDC |
| neurotransmitter binding | SLC6A11;NIPSNAP1;GRIN3B;SLC6A13;GRIN2A;GRIN1 |
| protein binding | NRG1;MATN4;SNRPA;BLMH;SFTPC;C2orf63;PIGS;FRMD4B;MED26 |
| protein heterodimerization activity | TLR6;KATNA1;HIST1H2BF;TBX15;CD3G;PVALB;BCL11A;SIM2;HIST1H2AF |
| voltage-gated cation channel activity | HVCN1;GRIK1;PKD2;GRIN2A;GRIN1 |
GRIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN1.
Tiam1; Tiam2; PLCB4; ERBB4
- Q&As
- Reviews
Q&As (5)
Ask a questionDysregulation of the NMDA receptor, due to GRIN1 mutations, has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's.
Disorders such as epilepsy, autism spectrum disorders, and schizophrenia have been linked to GRIN1 mutations.
Yes, genetic testing can identify mutations in the GRIN1 gene, which may be helpful in diagnosing certain neurological conditions.
The NMDA receptor, with GRIN1 as a subunit, is crucial for long-term potentiation, a process underlying memory formation and learning.
Some studies suggest that genetic variations in GRIN1 may influence an individual's response to antidepressant medications.
Customer Reviews (3)
Write a reviewThis strong track record of excellence further attests to the GRIN1 protein's capability to meet the rigorous demands of research projects.
Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.
Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.
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