GSK3A
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Official Full Name
glycogen synthase kinase 3 alpha
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Overview
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimers disease. [provided by RefSeq, Oct 2011] -
Synonyms
GSK3A; glycogen synthase kinase 3 alpha; glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Mammalian cells
- S.frugiperda
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
GSK3A involved in several pathways and played different roles in them. We selected most pathways GSK3A participated on our site, such as Chemokine signaling pathway, Dopaminergic synapse, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with GSK3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCL15;GNB1;NCF1;CCL27;CXCL3;CCL18;PRKCD;PF4V1;CCR1L1 |
| Dopaminergic synapse | CREB3L4;PPP1CB;GNG4;PPP2R2B;GNG12;PPP2R1B;CALM4;PPP2CA;GNB3 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFA11;PIK3CA;NDUFB10;KCNA3;PRKAG1;COX7A2;UQCRC2;INS1;UQCRC1 |
GSK3A has several biochemical functions, for example, ATP binding, protein binding, protein kinase A catalytic subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GSK3A itself. We selected most functions GSK3A had, and list some proteins which have the same functions with GSK3A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | STK24;AASDH;SRC;HSPA4B;AARS2;MELK;UBE2O;EPHA1;DNAH5 |
| protein binding | CHAMP1;TRAPPC6B;TMEM149;KRTAP3-3;ARF6;TNFRSF1A;TUT1;FREM2;SH2D1A |
| protein kinase A catalytic subunit binding | GSK3B;KCNQ1;PRKAR1B;RYR2;PRKAR2A;CSK;SOX9;PRKAR1A;PJA2 |
| protein serine/threonine kinase activity | DAPK2;C9orf96;PBK;GM711;ILK;SLC14A2;DCAMKL2;GRK1B;MAP2K1 |
| tau-protein kinase activity | MARK2;MARK4;PHKG1;CSNK1D;GSK3B;GSK3A;MARK1;PHKG2;CDK5 |
GSK3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSK3A here. Most of them are supplied by our site. Hope this information will be useful for your research of GSK3A.
YWHAG; AXIN1; GSKIP; FRAT1; DEAF1; LRP6; HSP90AB1; ZDHHC17; saicar; APP
- Q&As
- Reviews
Q&As (5)
Ask a questionGSK3A is implicated in insulin signaling and glucose metabolism, and its dysregulation is associated with insulin resistance, a key feature of type 2 diabetes.
Yes, GSK3A is implicated in pathways associated with mood regulation, and inhibitors are being investigated for their potential in treating mood disorders.
Yes, there is ongoing research to develop GSK3A modulators as potential anti-inflammatory agents.
GSK3A is involved in inflammatory signaling pathways, and its activity is linked to the regulation of inflammatory responses.
Researchers are investigating the potential of GSK3A inhibitors to improve insulin sensitivity and glucose homeostasis in diabetes.
Customer Reviews (3)
Write a reviewIts high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.
This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.
the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the GSK3A protein.
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