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GSTM4

  • Official Full Name

    glutathione S-transferase mu 4

  • Overview

    Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individuals susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
  • Synonyms

    GSTM4; glutathione S-transferase mu 4; glutathione S transferase M4; Glutathione S transferase Mu 4; GST class mu 4; GST class-mu 4; GST-Mu2; GSTM4 4; GSTM4-4; GSTM4_HUMAN; GTM4; GTS Mu2; MGC131945; MGC9247; GTS-Mu2; OTTHUMP00000013356; OTTHUMP00000013358; glutathione S-transferase M4; glutathione S-aryltransferase M4; glutathione S-alkyltransferase M4; glutathione S-aralkyltransferase M4; S-(hydroxyalkyl)glutath;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GSTM4-780H Recombinant Human Glutathione S-transferase Mu 4, His-tagged E.coli His
Human GSTM4-1692H Recombinant Human Glutathione S-Transferase Mu 4, His-tagged Human His
Human GSTM4-27770TH Recombinant Human GSTM4, His-tagged E.coli His 218 amino acids
Human GSTM4-27545TH Recombinant Human GSTM4, His-tagged E.coli His 218 amino acids
Human GSTM4-13577H Recombinant Human GSTM4, GST-tagged E.coli GST 1-218a.a.
Human GSTM4-4420H Recombinant Human GSTM4 Protein, GST-tagged Wheat Germ GST
Human GSTM4-5711HCL Recombinant Human GSTM4 293 Cell Lysate HEK293 N/A
Human GSTM4-1106H Recombinant Human GSTM4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GSTM4-3364HF Recombinant Full Length Human GSTM4 Protein, GST-tagged In Vitro Cell Free System GST 218 amino acids
Human GSTM4-2557H Recombinant Human GSTM4 Protein (Arg18-Trp215), N-His tagged E.coli N-His Arg18-Trp215
Mouse Gstm4-1069M Recombinant Mouse Gstm4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Gstm4-1604M Recombinant Mouse Gstm4 Protein, His-tagged E.coli N-His Ser16-Arg206
Rat Gstm4-652R Recombinant Rat Gstm4 protein, His & T7-tagged E.coli His/T7 Leu21~Trp215
Cynomolgus Monkey GSTM4-577C Recombinant Cynomolgus GSTM4 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey GSTM4-323C-B Recombinant Cynomolgus Monkey GSTM4 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey GSTM4-323C Recombinant Cynomolgus Monkey GSTM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GSTM4-1994R Recombinant Rhesus monkey GSTM4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GSTM4-1815R-B Recombinant Rhesus Macaque GSTM4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GSTM4-1815R Recombinant Rhesus Macaque GSTM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GSTM4 involved in several pathways and played different roles in them. We selected most pathways GSTM4 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with GSTM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glutathione metabolismGPX3;GPX1;GPX7;GGT6;GSTA5;GCLM;GSTP2;MGST1;GSTM
Metabolism of xenobiotics by cytochrome PUGT2A1;GSTM6;GSTM7;GSTA1;GSTT1B;UGT2B15;DHDHL;GSTAL;AKR7A5
Drug metabolism - cytochrome PADH1;UGT1A9;GSTA1;FMO4;ALDH3B1;GSTM4;ALDH3A1;AOX3;UGT1A6A
Chemical carcinogenesisCYP2E1;GSTA1;GSTA5;CYP3A7;CYP3A25;UGT1A4;UGT1A6B;HSD11B1;CYP2C19

GSTM4 has several biochemical functions, for example, enzyme binding, glutathione binding, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GSTM4 itself. We selected most functions GSTM4 had, and list some proteins which have the same functions with GSTM4. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingDNMT3L;LGALS9;BRCA1;RCOR2;GSTM4;KAT8;GNB2L1;CNTNAP2;HIST1H2AD
glutathione bindingLANCL1;PTGES2;PTGES;GSTM4;GSTM2;GSTM3;GSTM7;LTC4S;MGST1
glutathione transferase activityGSTZ1;GSTP2;GSTM4;GSTO2;GSTA3;HPGDS;MGST1;GSTM6;GSTA
protein bindingBCAR3;RIPK4;TRIM16;C14orf159;PMM2;SPA17;PPIG;NUBP1;GPATCH8
protein homodimerization activityTLR13;RXRB;SYNDIG1;OXA1L;SNX2;MAPK4;FGFR2;CUL3;ADD2

GSTM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GSTM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GSTM4.

GSTM3; TP53; APLP1; TLE1; ZBTB16; UNC119; RIF1; NELFCD; IGSF21; MED31

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