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GUCA1A

Official Full Name

guanylate cyclase activator 1A (retina)
Overview

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Synonyms

GUCA1A; guanylate cyclase activator 1A (retina); C6orf131, chromosome 6 open reading frame 131 , GUCA, GUCA1; guanylyl cyclase-activating protein 1; COD3; cone dystrophy 3; dJ139D8.6; GCAP; GCAP1; GCAP 1; guanylin 1, retina; guanylate cyclase-activating;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Insect Cells
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GUCA1A-487H	Recombinant Human GUCA1A, His-GST tagged	Insect Cell	His		Inquiry
Human	GUCA1A-28157TH	Recombinant Human GUCA1A	Wheat Germ	N/A	201 amino acids	Inquiry
Human	GUCA1A-4482H	Recombinant Human GUCA1A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GUCA1A-407H	Recombinant Human GUCA1A, Gly & Pro tagged	Insect Cell	His		Inquiry
Human	GUCA1A-001HCL	Recombinant Human GUCA1A cell lysate	Insect Cell	N/A		Inquiry
Human	GUCA1A-002HCL	Recombinant Human GUCA1A cell lysate	Insect Cell	N/A		Inquiry
Human	GUCA1A-3340HF	Recombinant Full Length Human GUCA1A Protein, GST-tagged	In Vitro Cell Free System	GST	201 amino acids	Inquiry
Human	GUCA1A-226HF	Recombinant Full Length Human GUCA1A Protein	In Vitro Cell Free System		201 amino acids	Inquiry
Human	GUCA1A-2549H	Recombinant Human GUCA1A Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	GUCA1A-1989H	Recombinant Human GUCA1A protein	Insect Cells	N/A	Met1-Gly201	Inquiry
Human	GUCA1A-1746H	Recombinant Human GUCA1A Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	GUCA1A-7383M	Recombinant Mouse GUCA1A Protein	Mammalian Cell	His		Inquiry
Mouse	GUCA1A-4006M	Recombinant Mouse GUCA1A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GUCA1A-4006M-B	Recombinant Mouse GUCA1A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	GUCA1A-9374Z	Recombinant Zebrafish GUCA1A	Mammalian Cell	His		Inquiry
Chicken	GUCA1A-5893C	Recombinant Chicken GUCA1A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GUCA1A Related Articles

GUCA1A involved in several pathways and played different roles in them. We selected most pathways GUCA1A participated on our site, such as Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUCA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phototransduction	GNB1B;GRK1A;SAG;GNAT1;PDE6B;OPN1MW4;RCVRN;RGS9;GRK7A

GUCA1A has several biochemical functions, for example, calcium ion binding, calcium sensitive guanylate cyclase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUCA1A itself. We selected most functions GUCA1A had, and list some proteins which have the same functions with GUCA1A. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	DGKA;RASGRP1;PCDH15A;CDH19;ZZEF1;PKD2L2;ARSA;APCS;RCVRNA
calcium sensitive guanylate cyclase activator activity	GUCA1D;GUCA1B;GUCA1G;GUCA1E;GUCA1A;GUCA1C;GUCA2B;RCVRN

GUCA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUCA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of GUCA1A.

HSPB1

Zobor, D; Zrenner, E; et al. GUCY2D- OR GUCA1A-RELATED AUTOSOMAL DOMINANT CONE-ROD DYSTROPHY Is There a Phenotypic Difference?. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 34:1576-1587(2014).

Lopez-del Hoyo, N; Lopez-Begines, S; et al. Functional EF-Hands in Neuronal Calcium Sensor GCAP2 Determine Its Phosphorylation State and Subcellular Distribution In Vivo, and Are Essential for Photoreceptor Cell Integrity. PLOS GENETICS 10:-(2014).