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GYS1

  • Official Full Name

    glycogen synthase 1 (muscle)

  • Overview

    The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    GYS1; glycogen synthase 1 (muscle); GYS; glycogen [starch] synthase, muscle; GSY;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 insect cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GYS1-13H Recombinant Human GYS1, GST-tagged Wheat Germ GST
Human GYS1-12H Recombinant Human GYS1, GST-tagged Wheat Germ GST
Human GYS1-11H Recombinant Human GYS1, MYC/DDK-tagged HEK293 Myc/DDK
Human GYS1-324H Recombinant Human GYS1 Protein, His-tagged E.coli His
Human GYS1-5670HCL Recombinant Human GYS1 293 Cell Lysate HEK293 N/A
Human GYS1-7984HFL Recombinant Full Length Human GYS1, Flag-tagged Mamanlian cells Flag
Human GYS1-910H Recombinant Human GYS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GYS1-219HF Recombinant Full Length Human GYS1 Protein, GST-tagged In Vitro Cell Free System GST 1 a.a. - 737 a.a.
Human GYS1-6947HF Recombinant Full Length Human GYS1 Protein, GST-tagged In Vitro Cell Free System GST 737 amino acids
Human GYS1-6946HF Recombinant Full Length Human GYS1 Protein, GST-tagged In Vitro Cell Free System GST 737 amino acids
Mouse GYS1-7407M Recombinant Mouse GYS1 Protein Mammalian Cell His
Mouse Gys1-1082M Recombinant Mouse Gys1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse GYS1-4021M Recombinant Mouse GYS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GYG/GYS1-02M Recombinant Mouse GYG/GYS1 Complex Protein, His/Strep-tagged Sf9 insect cells His/Strep GYG: 1-333<br />GYS1: 1-738
Mouse GYS1-4021M-B Recombinant Mouse GYS1 Protein Pre-coupled Magnetic Beads HEK293
Rat GYS1-2768R Recombinant Rat GYS1 Protein Mammalian Cell His
Rat GYS1-2422R-B Recombinant Rat GYS1 Protein Pre-coupled Magnetic Beads HEK293
Rat GYS1-2422R Recombinant Rat GYS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GYS1-2022R Recombinant Rhesus monkey GYS1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GYS1-1843R-B Recombinant Rhesus Macaque GYS1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GYS1-1843R Recombinant Rhesus Macaque GYS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish GYS1-11397Z Recombinant Zebrafish GYS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

GYS1 involved in several pathways and played different roles in them. We selected most pathways GYS1 participated on our site, such as Starch and sucrose metabolism, PIK-Akt signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GYS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Starch and sucrose metabolismUGT1A2;UGP2A;UGT2B7;UGP2B;PGM2;HK1;GBE1;AMY1B;AMY1A
PIK-Akt signaling pathwayIFNA7;PKN2;LAMA5;LAMB3;CREB3L2;TSC2;PRKCA;GYS1;AKT1
AMPK signaling pathwayPPP2R1A;ADIPOQ;IRS4;PPP2R5E;PIK3R5;PRKAG3;CREB3L4;TBC1D1;PPP2CA
Insulin signaling pathwayFOXO1;CALM2A;GSK3B;CALM2;MKNK2A;SOCS1A;ELK1;CALM1;IKBKB
Insulin resistanceG6PC;SLC27A4;PRKAB1A;PPP1CA;SLC2A1;GFPT2;RPS6KB1B;PYGL;GYS2

GYS1 has several biochemical functions, for example, glucose binding, glycogen (starch) synthase activity, glycogen synthase activity, transferring glucose-1-phosphate. Some of the functions are cooperated with other proteins, some of the functions could acted by GYS1 itself. We selected most functions GYS1 had, and list some proteins which have the same functions with GYS1. You can find most of the proteins on our site.

Function Related Protein
glucose bindingHK3;SLC2A8;HKDC1;G6PD;GYS1;G6PDX;HK2;SLC2A3;PYGL
glycogen (starch) synthase activityGYS1;GYS2
glycogen synthase activity, transferring glucose-1-phosphateGYS1;GYS2
protein bindingUSP22;KCNE4;SGTB;RNF2;PSMD9;ULK1;ZBTB7B;SOX7;LEO1
protein kinase bindingFER;KIF11;FGFR1OP;SLC12A5;CCNL1;FOXM1;BCL2L14;CCNB3;PLK1

GYS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GYS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GYS1.

GYG1; GSK3B; AIMP2; CCDC36; GABARAPL1; PASK; PRKAB2

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does GYS1 contribute to the regulation of blood glucose levels? 10/29/2022

It plays a significant role in maintaining blood glucose levels by regulating glycogen synthesis in response to hormonal signals.

What potential therapeutic applications could arise from targeting GYS1 in metabolic diseases? 08/29/2022

Targeting GYS1 could provide new strategies for managing metabolic conditions, including glycogen storage diseases and diabetes.

How do genetic mutations in the GYS1 gene affect glycogen storage and metabolism? 07/12/2022

Genetic mutations in GYS1 can lead to glycogen storage diseases, affecting glucose availability and energy balance.

What is the primary role of GYS1 in glycogen synthesis? 05/22/2022

GYS1, Glycogen Synthase 1, is crucial for the synthesis of glycogen, the primary storage form of glucose in the body.

What is the impact of altered GYS1 activity on metabolic disorders like diabetes? 10/24/2020

Altered GYS1 activity can impact glycogen storage and glucose metabolism, contributing to disorders like diabetes.

What role does GYS1 play in muscle and liver function? 10/12/2019

GYS1 is vital for muscle and liver function, where it facilitates energy storage and release.

How does GYS1 interact with hormonal signals like insulin and glucagon in glycogen metabolism? 12/30/2017

GYS1's activity is regulated by insulin and glucagon, which modulate glycogen synthesis in response to the body's energy needs.

Customer Reviews (3)

Write a review
Reviews
08/29/2022

    Critical for research success. Consistently trustworthy.

    10/24/2020

      Dependable service. A research must-have.

      12/30/2017

        Reliable data source. Elevates our research quality.

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