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H1F0

  • Official Full Name

    H1 histone family, member 0

  • Overview

    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H1 family.
  • Synonyms

    H1F0; H1 histone family, member 0; H1FV; histone H1.0; H1.0; H1(0); H1 0; H10; H1 histone family member 0; Histone H1; Histone H10; Histone H5; MGC5241; histone H1(0); H1.0, H1(0), H1-0;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Thymus
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human H1F0-2132H Recombinant Human H1 Histone Family, Member 0 E.coli N/A
Human H1F0-6945H Recombinant Human H1F0 protein, His-tagged E.coli His Met1-Lys194
Human H1F0-13640H Recombinant Human H1F0, GST-tagged E.coli GST 1-194a.a.
Human H1F0-100H Recombinant Human H1F0 Protein E.coli N/A 1-194
Human H1F0-4528H Recombinant Human H1F0 Protein, GST-tagged Wheat Germ GST
Human H1F0-2117HCL Recombinant Human H1F0 cell lysate N/A
Human H1F0-3395HF Recombinant Full Length Human H1F0 Protein, GST-tagged In Vitro Cell Free System GST 194 amino acids
Mouse H1F0-7420M Recombinant Mouse H1F0 Protein Mammalian Cell His
Mouse H1F0-4035M-B Recombinant Mouse H1F0 Protein Pre-coupled Magnetic Beads HEK293
Mouse H1F0-4035M Recombinant Mouse H1F0 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat H1F0-2773R Recombinant Rat H1F0 Protein Mammalian Cell His
Rat H1F0-2427R-B Recombinant Rat H1F0 Protein Pre-coupled Magnetic Beads HEK293
Rat H1F0-2427R Recombinant Rat H1F0 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine H1F0-01B Native Bovine H1F0 Protein Thymus 1-213 (H1.2), 1-221 (H1.3), and 1-219 (H1.4)
Zebrafish H1F0-9956Z Recombinant Zebrafish H1F0 Mammalian Cell His
Chicken H1F0-3465C Recombinant Chicken H1F0 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • H1F0 Related Articles
  • H1F0 Related Research Area

H1F0 involved in several pathways and played different roles in them. We selected most pathways H1F0 participated on our site, such as Activation of DNA fragmentation factor, Apoptosis, Apoptosis induced DNA fragmentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with H1F0 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of DNA fragmentation factorHIST1H1A;HMGB2A;HMGB2;HIST1H1B;DFFA;HIST1H1E;H1F0;HIST1H1C;HIST1H1D
ApoptosisRIPK1L;DAPK1;IRAK2;Fasl;CTNNB2;CASP3A;RIPK1;PPP3R1B;CASP6L2
Apoptosis induced DNA fragmentationDFFA;HIST1H1E;HIST1H1D;HIST1H1B;HIST1H1C;HMGB2;HIST1H1A;H1F0;HMGB2A
Apoptotic execution phaseCASP6L1;DFFA;DBNLB;GAS2;CLSPN;STK26;HIST1H1A;PTBP3;HIST1H1C
Cellular SenescenceCBX6;SUZ12B;PHC3;EHMT2;TXN;KDM6B;SUZ12;BMI1B;CBX4
Cellular responses to stressPRDX3;PRDX2;H3F3B.1;RB1CC1;WDR45;POT1;C11orf73;WIPI1;KDM6B
DNA Damage/Telomere Stress Induced SenescenceHMGA1;UBN1;TINF2;HIST1H1D;HIST1H1A;ASF1A;CABIN1;H1F0;HIRA
Formation of Senescence-Associated Heterochromatin Foci (SAHF)HIRA;EP400;HIST1H1C;HIST1H1E;ASF1A;CABIN1;HIST1H1D;HIST1H1B;HMGA1B

H1F0 has several biochemical functions, for example, chromatin DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H1F0 itself. We selected most functions H1F0 had, and list some proteins which have the same functions with H1F0. You can find most of the proteins on our site.

Function Related Protein
chromatin DNA bindingHIST1H1D;RXRA;AASS;CLOCK;NEUROG3;H2AFY;GRHL3;RELA;GRHL2
poly(A) RNA bindingCOX4I2;HNRNPL;CCDC9;RBM47;CSTF1;RPGR;RBM39;HNRNPA0;RRP9
protein bindingMAGEB6;GRHL3;DNAI1;CKS1B;VIPAS39;RACGAP1;CAP2;MRFAP1;TFF2

H1F0 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H1F0 here. Most of them are supplied by our site. Hope this information will be useful for your research of H1F0.

RAD51B; E1; par; IKBKG; lt_sv40; GRB2; NOA1; 2_aha_camp; ssrna_cg

Wade, MG; Kawata, A; et al. Methoxyacetic acid-induced spermatocyte death is associated with histone hyperacetylation in rats. BIOLOGY OF REPRODUCTION 78:822-831(2008).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a relationship between the expression level of H1F0 and the disease? 05/04/2022

Studies have shown that the expression level of H1F0 is associated with a variety of diseases. For example, in some cancers, the expression level of H1F0 is upregulated, which promotes the proliferation and metastasis of tumor cells. In some neurodegenerative diseases, the expression of H1F0 may be down-regulated, leading to cell death.

What is the relationship of H1F0 to other genes or proteins? 10/06/2021

H1F0 has a complex relationship with other genes or proteins. For example, it interacts with some transcription factors and regulatory proteins of signal transduction pathways, affecting gene expression and cell signal transduction. In addition, H1F0 is also affected by some epigenetic modifications, such as methylation and acetylation.

How can we better understand the role of H1F0 in disease? 03/26/2021

In order to better understand the role of H1F0 in diseases, further in-depth research is needed on its specific mechanism of action and function. In addition, it is also necessary to study the changes in its expression level and activity in different diseases, as well as its relationship with the occurrence and development of diseases. At the same time, it is also necessary to explore the clinical application prospects and effects of the therapeutic strategies that regulate them.

What is the location and role of H1F0 in cells? 05/12/2020

H1F0 is mainly located in the nucleus, binds to chromatin (DNA-protein complex) and regulates its structure. It is able to influence the way DNA is folded and packaged, which in turn affects gene expression and DNA repair. In addition, H1F0 is also involved in the regulation of cell division and cell cycle.

What are the limitations of research on H1F0? 02/24/2020

There are still some limitations in the current research on H1F0, such as the lack of in-depth research on its specific mechanism and function, and the incomplete understanding of its relationship with diseases. In addition, since H1F0 is a multifunctional protein, regulating it may also have some side effects.

Is there a treatment strategy for H1F0? 12/02/2019

Therapeutic strategies for H1F0 include inhibiting its expression, modulating its activity, or using gene therapy. For example, some studies have shown that the use of small molecule inhibitors targeting H1F0 can inhibit its activity and thus treat some H1F0-related diseases. In addition, related diseases can also be treated by regulating the expression level of H1F0.

Customer Reviews (3)

Write a review
Reviews
09/13/2023

    H1F0 has good stability and long-term storage without problems.

    06/08/2023

      Strong stability, can form a stable micelle structure.

      11/18/2021

        It performs well in western blotting experiments.

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