h2afy
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  • Official Full Name
  • H2A histone family, member Y
  • Background
  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • H2AFY; H2A histone family, member Y; core histone macro-H2A.1; macroH2A1.2; Core histone macro h2a.1; H2A histone family member Y; H2A.y; H2A/y; Histone macroH2A1; Histone macroH2A1.1; Histone macroH2A1.2; Macroh2a1; Medulloblastoma antigen MU MB 50.205; mH2a; mH2A1; histone H2A.y; OTTHUMP00000159413; OTTHUMP00000223174; OTTHUMP00000223175; OTTHUMP00000223176; medulloblastoma antigen MU-MB-50.205; H2AFJ; H2AF12M; MACROH2A1.1
Cat.#:H2AFY-4538HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human H2AFY Protein, GST-tagged
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Cat.#:H2AFY-117HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human H2AFY protein, T7/His-tagged
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Cat.#:H2AFY-133HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human H2AFY Protein, HIS-tagged
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Cat.#:H2AFY-1705HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human H2AFY protein, His & GST-tagged
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Cat.#:H2AFY-2776RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat H2AFY Protein
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Cat.#:H2AFY-2028RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey H2AFY Protein, His-tagged
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Cat.#:H2AFY-6565CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken H2AFY
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Cat.#:H2AFY-3784ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish H2AFY
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Cat.#:H2AFY-5657HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human H2AFY 293 Cell Lysate
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Cat.#:H2AFY-5658HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human H2AFY 293 Cell Lysate
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Involved Pathway

H2AFY involved in several pathways and played different roles in them. We selected most pathways H2AFY participated on our site, such as Alcoholism, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H2AFY were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
HDAC7A; GNG8; HIST1H2BQ; HIST1H4B; GNG5; TH; HIST1H4L; HIST3H2A; HIST1H3F; CALML5
Systemic lupus erythematosus
CD40LG; HLA-DRB5; C1QA; HLA-DQA2; H2AFZ; HIST1H2AD; H2BFWT; CD86; HIST1H2BG; HLA-DMA

Protein Function

H2AFY has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by H2AFY itself. We selected most functions H2AFY had, and list some proteins which have the same functions with H2AFY. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein EHF; PROX1B; ARX; ZNF692; ZNF177; SYCP1; TWIST2; RAG1; INSM1A; ZNF230
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein RUNX2; ZNF277; SOX11; H3F3B; TP53; HOXB3; TRP53; PAX8; FOS; STAT6
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein STAT4; BHLHA15; PHOX2A; TAL2; ZNF792; BARHL1A; ARID3A; TBX20; NR1I3; ZNF691
Function chromatin DNA binding
Related Protein MYOD1; HDAC3; H2AFZ; GRHL2; CLOCK; RUVBL2; XBP1; MYOG; INSM1A; HIST1H1C
Function core promoter sequence-specific DNA binding
Related Protein CHD2; H2AFY; PDX1; NR1D2; PROX1; NFYA; NR1D1; PRMT5; SIRT1; MLL1
Function double-stranded methylated DNA binding
Related Protein MECP2; MBD1; H2AFY
Function nucleosomal DNA binding
Related Protein RCC1; HMGN4; H1FOO; H2AFZ; HMGN5; H2AFY; NSBP1; HNRNPC; HMGA2; H3F3A
Function protein binding
Related Protein LAIR1; TRPM6; EPHA10; USP4; DRD1; CSF1; MEIS1B; DDX23; PTI; AGPAT4
Function protein heterodimerization activity
Related Protein KCNA3; ATF4; HIST1H3G; GABRR1; GTF2A2; FLOT2; UGT1A9; PKNOX1; SOX6; MYOG
Function protein kinase binding
Related Protein DLG1; NPR1; PPP1R12A; SYN1; GPRC5B; PTK2; ACTA2; STX1B; CACNB2; ACSL3
Function protein serine/threonine kinase inhibitor activity
Related Protein CIB1; SPRED1; SPRED2; H2AFY; SPRY2
Function rDNA binding
Related Protein H2AFY; GTF2H5; BEND3
Function transcription regulatory region DNA binding
Related Protein GATA5; CDK5RAP2; MTERFD3; FOXC2; SOX2; IKZF4; FOXI1; HOXA13; NR1H3; BCOR

Interacting Protein

H2AFY has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H2AFY here. Most of them are supplied by our site. Hope this information will be useful for your research of H2AFY.
ERICH2; ERBB2; ATF2; SRPK1; q7chd7_yerpe; yapB; PARP1; VCAM1; CD247; ATRX