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HACE1

  • Official Full Name

    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

  • Synonyms

    HACE1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase HACE1; KIAA1320; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin p;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HACE1-4552H Recombinant Human HACE1 Protein, GST-tagged Wheat Germ GST
Human HACE1-5648HCL Recombinant Human HACE1 293 Cell Lysate HEK293 N/A
Human HACE1-0420H Recombinant Human HACE1 Protein (E2-A909), Tag Free E.coli No tag E2-A909
Human HACE1-1039H Recombinant Human HACE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HACE1-1087HFL Recombinant Full Length Human HACE1 Protein, C-Flag-tagged Mammalian cells Flag
Human HACE1-0421H Recombinant Human HACE1 Protein (E2-A909), His tagged E.coli His E2-A909
Human HACE1-1039H-B Recombinant Human HACE1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HACE1-7466M Recombinant Mouse HACE1 Protein Mammalian Cell His
Mouse Hace1-3350M Recombinant Mouse Hace1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HACE1-4049M-B Recombinant Mouse HACE1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HACE1-4049M Recombinant Mouse HACE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken HACE1-5404C Recombinant Chicken HACE1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HACE1 Related Articles

HACE1 involved in several pathways and played different roles in them. We selected most pathways HACE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HACE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

HACE1 has several biochemical functions, for example, Rab GTPase binding, Rac GTPase binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HACE1 itself. We selected most functions HACE1 had, and list some proteins which have the same functions with HACE1. You can find most of the proteins on our site.

Function Related Protein
Rab GTPase bindingRUSC2;ACAP2;SYTL4;HPS6;ERC1;UNC13D;TBC1D30;AP1G1;RABGAP1
Rac GTPase bindingARHGAP4;HACE1;SRGAP3;PAK7;SRGAP2A;PAK6;PAK2;RCC2;DOCK4
ligase activityRNF149;MARCH6;TRIM68;CDC34B;RNF170;RNF14;TRIM33;MARCH5L;GATB
protein bindingGTF2E1;RASL11A;HEMGN;PEX13;NUP98;NDUFB10;BIRC7;TFDP1;CUL2
ubiquitin protein ligase activityRNF6;UBE2A;TRIM32;MED10;UBR3;UHRF2;RNF25;MED7;TRIP12
ubiquitin-protein transferase activityLMO7;RNF220;TRIM68;RBBP6;PDZRN3;MARCH5L;RNF130;HUWE1;BIRC5

HACE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HACE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HACE1.

OPTN; ubiq_human; USP2; UBA1

Rotblat, B; Southwell, AL; et al. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:3032-3037(2014).
Castillo-Lluva, S; Tan, CT; et al. The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation. ONCOGENE 32:1735-1742(2013).
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