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HADHA

  • Official Full Name

    hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

  • Overview

    This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
  • Synonyms

    HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; GBP; ECHA; HADH; LCEH; MTPA; LCHAD; TP-ALPHA; trifunctional enzyme subunit alpha, mitochondrial; 3-oxoacyl-CoA thiolase; gastrin-binding protein; 78 kDa gastrin-binding protein; long-chain 2-enoyl-CoA hydratase; long-chain-3-hydroxyacyl-CoA dehydrogenase; mitochondrial trifunctional enzyme, alpha subunit; mitochondrial trifunctional protein, alpha subunit; 3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit; mitochondrial long-chain 2-enoyl-Coenzyme A (CoA) hydratase, alpha subunit; mitochondrial long-chain L-3-hydroxyacyl-Coenzyme A (CoA) dehydrogenase, alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • E.coli
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HADHA-13658H Recombinant Human HADHA, GST-tagged E.coli GST C-term-416a.a.
Human HADHA-2120HCL Recombinant Human HADHA cell lysate N/A
Mouse HADHA-2774M Recombinant Mouse HADHA Protein (348-763 aa), His-Myc-tagged Insect Cell His/Myc 348-763 aa
Rat HADHA-2782R Recombinant Rat HADHA Protein Mammalian Cell His
Rat HADHA-2436R Recombinant Rat HADHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HADHA-2436R-B Recombinant Rat HADHA Protein Pre-coupled Magnetic Beads HEK293
E.coli HADHA-2613M Recombinant Mouse HADHA Protein (348-763 aa), His-Myc-tagged E.coli His/Myc 348-763 aa
Rhesus Macaque HADHA-2033R Recombinant Rhesus monkey HADHA Protein, His-tagged Mammalian Cell His
Rhesus Macaque HADHA-1854R Recombinant Rhesus Macaque HADHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HADHA-1854R-B Recombinant Rhesus Macaque HADHA Protein Pre-coupled Magnetic Beads HEK293
Chicken HADHA-6613C Recombinant Chicken HADHA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HADHA involved in several pathways and played different roles in them. We selected most pathways HADHA participated on our site, such as Fatty acid elongation, Fatty acid degradation, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HADHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid elongationACOT2;ACOT7;HADHB;ELOVL5;PTPLAD2;HSD17B12;ELOVL1;ELOVL3;MECR
Fatty acid degradationALDH2.1;ACSL1B;ACAA1A;ACSL5;ACAT2;ALDH3A2;ADH6;CPT2;HADH
Valine, leucine and isoleucine degradationOXCT2B;BCAT1;BCKDHB;ALDH7A1;BCAT2;OXCT1;ACAA1;AOX2P;MCCC2
Lysine degradationBBOX1;SETMAR;AGPHD1;OGDHA;ALDH9A1;WHSC1L1;SUV39H1;EHMT2;EHMT1
Tryptophan metabolismAOX4;TPH1A;KYNU;HADH;ANI_1_2390104;ALDH2.1;ALDH3A2A;TPH1B;CYP2F1
beta-Alanine metabolismALDH9A1B;HIBCH;MLYCD;AOC2;GAD1;CNDP1;ALDH3B2;ALDH1A3;ALDH6A1
Propanoate metabolismLDHAL6A;PCCA;MCEE;LDHB;HADHAB;ACADM;BCKDHB;ACAT2;MUT
Butanoate metabolismHADHAA;HMGCL;OXCT1A;ACADS;ACSM4;OXCT2A;OXCT2;GAD1B;HMGCS1
Biosynthesis of unsaturated fatty acidsBAAT;HADHA;ACOT1;HADHAB;Scd1;ELOVL2;ACOT5;ACOX1;ELOVL6
Metabolic pathwaysATP5F1;HIBADHB;NDUFB10;ACAD8;CYP2C19;B3GNT4;PLCD4;GALCB;MTMR1
Carbon metabolismPGK2;TKTL2;PCXB;AGXTA;OGDH;ACO1;TPI1A;PDHA1A;ACAT2
Fatty acid metabolismHADHB;HADHA;ACADM;TECRB;FADS2;ELOVL5;HSD17B12B;HADHAB;ACAT1

HADHA has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity, NAD binding, acetyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HADHA itself. We selected most functions HADHA had, and list some proteins which have the same functions with HADHA. You can find most of the proteins on our site.

Function Related Protein
3-hydroxyacyl-CoA dehydrogenase activityHADHAA;HSD17B8;HSD17B10;H2-KE6;EHHADH;HADHA;HADHB;HADHAB;HADH
NAD bindingPARP1;NNT;AOX1;AOX4;HPGD;IDH3G;ME2;UGDH;MDH1
acetyl-CoA C-acetyltransferase activityACAT2;ACAA1A;HADHA;ACAT1
enoyl-CoA hydratase activityECHS1;EHHADH;HADHAB;AUH;HADHB;HADHAA;HADHA
fatty-acyl-CoA bindingGCDHA;ACBD7;ACBD6;ACADM;HADHA;ACADVL;ACOT7;ETFA;ACBD5
long-chain-3-hydroxyacyl-CoA dehydrogenase activityHADHA;HADHB
long-chain-enoyl-CoA hydratase activityHSD17B4;HADHA
protein bindingFAM81B;MOBKL2B;KIAA0408;CABLES1;C11orf54;SENP5;DIAP1;TOLLIP;SPATC1
protein complex bindingUFD1L;ULK1;CRIPT;MAPK8IP2;SIX2;NASP;PPP4C;CALY;TULP2

HADHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HADHA here. Most of them are supplied by our site. Hope this information will be useful for your research of HADHA.

GABARAP; MAP1LC3B; TRAF6; GABARAPL2; GABARAPL1; MAP1LC3A

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