Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

HADHA

  • Official Full Name

    hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

  • Overview

    This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
  • Synonyms

    HADHA; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; GBP; ECHA; HADH; LCEH; MTPA; LCHAD; TP-ALPHA; trifunctional enzyme subunit alpha, mitochondrial; 3-oxoacyl-CoA thiolase; gastrin-binding protein; 78 kDa gastrin-binding protein; long-chain 2-enoyl-CoA hydratase; long-chain-3-hydroxyacyl-CoA dehydrogenase; mitochondrial trifunctional enzyme, alpha subunit; mitochondrial trifunctional protein, alpha subunit; 3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit; mitochondrial long-chain 2-enoyl-Coenzyme A (CoA) hydratase, alpha subunit; mitochondrial long-chain L-3-hydroxyacyl-Coenzyme A (CoA) dehydrogenase, alpha subunit; hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • E.coli
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HADHA-13658H Recombinant Human HADHA, GST-tagged E.coli GST C-term-416a.a.
Human HADHA-2120HCL Recombinant Human HADHA cell lysate N/A
Mouse HADHA-2774M Recombinant Mouse HADHA Protein (348-763 aa), His-Myc-tagged Insect Cell His/Myc 348-763 aa
Rat HADHA-2782R Recombinant Rat HADHA Protein Mammalian Cell His
Rat HADHA-2436R Recombinant Rat HADHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HADHA-2436R-B Recombinant Rat HADHA Protein Pre-coupled Magnetic Beads HEK293
E.coli HADHA-2613M Recombinant Mouse HADHA Protein (348-763 aa), His-Myc-tagged E.coli His/Myc 348-763 aa
Rhesus Macaque HADHA-2033R Recombinant Rhesus monkey HADHA Protein, His-tagged Mammalian Cell His
Rhesus Macaque HADHA-1854R Recombinant Rhesus Macaque HADHA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HADHA-1854R-B Recombinant Rhesus Macaque HADHA Protein Pre-coupled Magnetic Beads HEK293
Chicken HADHA-6613C Recombinant Chicken HADHA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HADHA involved in several pathways and played different roles in them. We selected most pathways HADHA participated on our site, such as Fatty acid elongation, Fatty acid degradation, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HADHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid elongationELOVL3;PPT2;PTPLA;ELOVL6;ELOVL4B;PTPLAD1;HADH;HSD17B12B;ELOVL5
Fatty acid degradationALDH2;ADH2-1;ALDH7A1;HADHAB;PECI;ADH1B;ADH7;ACADM;ADH1
Valine, leucine and isoleucine degradationALDH9A1;ALDH2.2;HMGCLL1;BCKDHB;ACAT1;ACADSB;OXCT2B;MUT;HIBCH
Lysine degradationEHHADH;OGDHL;SETDB1;GCDHB;GLT25D2;KMT2A;SETD8A;EHMT1A;ALDH1B1
Tryptophan metabolismHADH;CYP4F12;CYP2F1;ALDH1B1;CAT;AADAT;AOX1;AANAT;AOX4
beta-Alanine metabolismGAD2;ALDH3A2A;AOC3;MLYCD;ALDH3B2;ALDH2;ALDH6A1;ALDH1B1;ALDH3A1
Propanoate metabolismALDH6A1;ACSS3;ACAT2;ackA;SUCLG2;LDHAL6B;ACSS2L;LDHC;BCKDHA
Butanoate metabolismACSM2;ACSM1;ACSM5;ACSM3;OXCT2A;GAD2;BDH1;HADHAA;L2HGDH
Biosynthesis of unsaturated fatty acidsACAA1;ACOT1;HSD17B12B;PTPLA;HSD17B12A;ACAA1A;ACOT2;ACOX3;SCD
Metabolic pathwaysPPOX;KHK;AGPAT9;FUT5;ENPP7;PCXB;PDHA1A;AKR1A1A;ATIC
Carbon metabolismSDHDB;SDHC;AGXT;PGAM2;ME1;ADH5;PCCA;GPT2L;SHMT2
Fatty acid metabolismFADS1;ACAA1A;ACOX3;ACAA1;HADHA;ACSL4;ACSL5;ELOVL5;CPT2

HADHA has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity, NAD binding, acetyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HADHA itself. We selected most functions HADHA had, and list some proteins which have the same functions with HADHA. You can find most of the proteins on our site.

Function Related Protein
3-hydroxyacyl-CoA dehydrogenase activityHSD17B8;HADHA;HADH;H2-KE6;HADHAA;HSD17B10;HADHAB;HSD17B4;HADHB
NAD bindingGRHPRB;UGDH;SORD;HIBADHA;HSD17B10;IDH3G;PHGDH;HADHA;HSD11B2
acetyl-CoA C-acetyltransferase activityHADHA;ACAT1;ACAA1A;ACAT2
enoyl-CoA hydratase activityECHS1;HADHB;HADHA;EHHADH;HADHAB;HADHAA;AUH
fatty-acyl-CoA bindingACAD9;GCDH;GCDHB;ACBD6;ACADM;ACBD3;ACADS;ACOX2;SCP2
long-chain-3-hydroxyacyl-CoA dehydrogenase activityHADHB;HADHA
long-chain-enoyl-CoA hydratase activityHSD17B4;HADHA
protein bindingBLOC1S2;BATF3;LSM4;SPHK2;DCTN1;KANSL2;ENOX1;MCM3;MAP1LC3C
protein complex bindingCASP8;VDAC1;PPIB;AP2B1;SREBF1;KCTD5;SKAP1;UQCRC1;BAX

HADHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HADHA here. Most of them are supplied by our site. Hope this information will be useful for your research of HADHA.

GABARAP; MAP1LC3B; TRAF6; GABARAPL2; GABARAPL1; MAP1LC3A

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HADHA Products

Required fields are marked with *

My Review for All HADHA Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends