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HADHB

  • Official Full Name

    hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit

  • Overview

    This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. Mutations in this gene result in trifunctional protein deficiency. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Alternatively spliced transcript variants have been found; however, their full-length nature is not known.
  • Synonyms

    HADHB; hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit; hydroxyacyl Coenzyme A dehydrogenase/3 ketoacyl Coenzyme A thiolase/enoyl Coenzyme A hydratase (trifunctional protein), beta subunit; trifunctional enzyme subunit beta, mitochondrial; mitochondrial trifunctional protein; beta subunit; MTPB; 2 enoyl Coenzyme A (CoA) hydratase beta subunit; 3 ketoacyl Coenzyme A (CoA) thiolase of mitochondrial trifunctional protein beta subunit; 3 ketoacyl Coenzyme A thiolase; 3 ketoacyl Coenzyme A thiolase of mitochondrial trifunctional protein beta subunit; 3-ketoacyl-CoA thiolase; Acetyl CoA acyltransferase; Acetyl-CoA acyltransferase; Beta ketothiolase; Beta-ketothiolase; ECHB; ECHB_HUMAN; HADH; Hydroxyacyl Coenzyme A (CoA) dehydrogenase beta subunit; Hydroxyacyl Coenzyme A dehydrogenase; Hydroxyacyl Coenzyme A dehydrogenase beta subunit; Hydroxyacyl Coenzyme A dehydrogenase/3 ketoacyl Coenzyme A thiolase/enoyl Coenzyme A hydratase (trifunctional protein) beta subunit; MGC87480; Mitochondrial trifunctional enzyme beta subunit; Mitochondrial trifunctional protein beta subunit; MS733; MSTP 029; MSTP029; TP beta; TP-beta; TPbeta; Trifunctional enzyme subunit beta; Trifunctional enzyme subunit beta mitochondrial; Trifunctional protein; OTTHUMP00000122456; OTTHUMP00000200808; 2-enoyl-Coenzyme A (CoA) hydratase, beta subunit; mitochondrial trifunctional enzyme, beta subunit; mitochondrial trifunction;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HADHB-4555H Recombinant Human HADHB Protein, GST-tagged Wheat Germ GST
Human HADHB-5645HCL Recombinant Human HADHB 293 Cell Lysate HEK293 N/A
Human HADHB-1193H Recombinant Human HADHB Protein (35-283 aa), GST-tagged E.coli GST 35-283 aa
Human HADHB-3445HF Recombinant Full Length Human HADHB Protein, GST-tagged In Vitro Cell Free System GST 474 amino acids
Mouse HADHB-7469M Recombinant Mouse HADHB Protein Mammalian Cell His
Mouse HADHB-4052M-B Recombinant Mouse HADHB Protein Pre-coupled Magnetic Beads HEK293
Mouse Hadhb-4762M Recombinant Mouse Hadhb protein, His&Myc-tagged E.coli His&Myc 35-475aa
Mouse Hadhb-1715M Recombinant Mouse Hadhb protein, His & T7-tagged E.coli His/T7 Met1~Glu259 (Accession # Q99JY0)
Mouse HADHB-4052M Recombinant Mouse HADHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HADHB-2783R Recombinant Rat HADHB Protein Mammalian Cell His
Rat HADHB-2437R-B Recombinant Rat HADHB Protein Pre-coupled Magnetic Beads HEK293
Rat HADHB-2437R Recombinant Rat HADHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HADHB-10378Z Recombinant Zebrafish HADHB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HADHB involved in several pathways and played different roles in them. We selected most pathways HADHB participated on our site, such as Fatty acid elongation, Fatty acid degradation, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HADHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid elongationTECRB;ELOVL6;ELOVL1B;HADH;ELOVL1;HADHB;PPT1;ELOVL4B;PPT2
Fatty acid degradationALDH2;ADH1A;ACAT1;ACSBG1;ADH1C;ADH1B;CPT1A;ALDH9A1A.1;ECI1
Valine, leucine and isoleucine degradationACADM;MCCC2;ALDH3A2;PCCA;OXCT2B;ACAA2;ALDH9A1A.1;HMGCLL1;ACAA1A
Metabolic pathwaysHMGCR;LPCAT1;PFKP;PPOX;HPD;NDUFA8;CYP3A41A;PLCB3;NT5C3A
Fatty acid metabolismACADVL;PPT1;ELOVL5;MCAT;ACSL1A;PECR;ACAT2;ACSBG2;HSD17B12

HADHB has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity, acetyl-CoA C-acyltransferase activity, enoyl-CoA hydratase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HADHB itself. We selected most functions HADHB had, and list some proteins which have the same functions with HADHB. You can find most of the proteins on our site.

Function Related Protein
3-hydroxyacyl-CoA dehydrogenase activityH2-KE6;HSD17B10;HADHAA;EHHADH;HSD17B4;HADHA;HADHB;HADH;HADHAB
acetyl-CoA C-acyltransferase activityACAA2;ACAA1A;HADHB;ACAA1
enoyl-CoA hydratase activityEHHADH;ECHS1;HADHA;AUH;HADHAA;HADHAB;HADHB
long-chain-3-hydroxyacyl-CoA dehydrogenase activityHADHB;HADHA
poly(A) RNA bindingPCBP1;ABT1;ALDH18A1;WDR3;RC3H2;GNL2;DBR1;SUPV3L1;IFIT2
protein bindingCTNNBL1;FIS1;PARL;DST;TSPAN15;PI4KA;CYHR1;RORB;TPX2

HADHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HADHB here. Most of them are supplied by our site. Hope this information will be useful for your research of HADHB.

MYC; GABARAPL1; GABARAPL2; MAP1LC3B; MAP1LC3A; vpu

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