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HAMP

  • Official Full Name

    hepcidin antimicrobial peptide

  • Overview

    The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]
  • Synonyms

    HAMP; hepcidin antimicrobial peptide; HEPC; PLTR; HFE2B; LEAP1; hepcidin; putative liver tumor regressor; liver-expressed antimicrobial peptide 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Cattle
  • Dog
  • Human
  • Larimichthys Crocea
  • Mouse
  • Pig
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • GST
  • His
  • His|Fc
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HAMP-280H Recombinant Human HAMP protein, GST-tagged E.coli GST
Human HAMP-458H Recombinant Human HAMP protein, His & Fc-tagged HEK293F His/Fc Ser25~Thr84
Human HAMP-2057H Recombinant Human HAMP protein, His-tagged E.coli His Ser25~Thr84
Human HAMP-4564H Recombinant Human HAMP Protein, GST-tagged Wheat Germ GST
Human HAMP-12H Recombinant Human HAMP, MYC/DDK-tagged HEK293 Myc/DDK
Human HAMP-5640HCL Recombinant Human HAMP 293 Cell Lysate HEK293 N/A
Human HAMP-955H Recombinant Human HAMP Protein, His-tagged HEK293F N-His Ser25-Thr84
Human HAMP-3454HF Recombinant Full Length Human HAMP Protein, GST-tagged In Vitro Cell Free System GST 84 amino acids
Human HAMP-9191HFL Recombinant Full Length Human HAMP, Flag-tagged Mamanlian cells Flag
Human HAMP-3599H Recombinant Human HAMP Protein (Asp60-Thr84), N-GST tagged E.coli N-GST Asp60-Thr84
Human HAMP-3600H Recombinant Human HAMP Protein (Ser25-Thr84), His tagged E.coli His Ser25-Thr84
Mouse Hamp-2058M Recombinant Mouse Hamp protein, His-tagged E.coli His Thr24~Thr83
Mouse Hamp-3354M Recombinant Mouse Hamp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Hamp-2060R Recombinant Rat Hamp protein, His & GST-tagged E.coli His/GST Gly23~Thr84
Dog HAMP-2732D Recombinant Dog HAMP Protein, His&GST-tagged E.coli N-His&GST Val23-Thr85
Cattle HAMP-2056C Recombinant Cattle HAMP protein, His & GST-tagged E.coli His/GST Gln29~Thr82 (Accession # Q2NKT0)
Larimichthys Crocea HAMP-2268L Recombinant Larimichthys Crocea HAMP Protein (65-85 aa) E.coli N/A 65-85 aa
Zebrafish HAMP-11623Z Recombinant Zebrafish HAMP Mammalian Cell His
Zebrafish HAMP-8408Z Recombinant Zebrafish HAMP Mammalian Cell His
Pig HAMP-2059P Recombinant Pig HAMP protein, His & GST-tagged E.coli His/GST Gly23~Thr82 (Accession # Q8MJ80)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HAMP Related Articles

HAMP involved in several pathways and played different roles in them. We selected most pathways HAMP participated on our site, such as Iron metabolism in placenta, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Iron metabolism in placentaHAMP;TFR2;IREB2

HAMP has several biochemical functions, for example, copper ion binding, hormone activity, iron channel inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HAMP itself. We selected most functions HAMP had, and list some proteins which have the same functions with HAMP. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingSERPINB1A;ATOX1;LOX;MT3;RNF7;LOXL5B;ANG;SCO1;SLC11A2
hormone activityAGT;EDN2;RLN3A;PTH;INHBAB;GNRH1;FSHB;PRL3C1;PRL7C1
iron channel inhibitor activity
receptor bindingIAPP;CADM4;ECI2;INHA;A2M;PGR;TNFSF15;F2;DPP4

HAMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAMP here. Most of them are supplied by our site. Hope this information will be useful for your research of HAMP.

CKAP4; q9wmx2-pro_0000037550

Tang, YH; Li, YY; et al. Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 25:675-682(2014).
Li, X; Xu, F; et al. Allogeneic Transplantation, Fas Signaling, and Dysregulation of Hepcidin. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19:1210-1219(2013).
  • Q&As
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