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HCFC1

  • Official Full Name

    host cell factor C1 (VP16-accessory protein)

  • Overview

    This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Synonyms

    HCFC1; host cell factor C1 (VP16-accessory protein); HFC1; host cell factor 1; CFF; HCF 1; HCF1; MGC70925; VCAF; HCF; C1 factor; VP16 accessory protein; HCF-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCFC1-4617H Recombinant Human HCFC1 Protein, GST-tagged Wheat Germ GST
Human HCFC1-29188TH Recombinant Human HCFC1 Wheat Germ N/A 87 amino acids
Human HCFC1-13692H Recombinant Human HCFC1, GST-tagged E.coli GST 1-350a.a.
Human HCFC1-407H Recombinant Human HCFC1 Protein, His-tagged E.coli His Asn52~His258
Human HCFC1-3505HF Recombinant Full Length Human HCFC1 Protein, GST-tagged In Vitro Cell Free System GST 428 amino acids
Human HCFC1-3353H Recombinant Human HCFC1 Protein (Asn52-His258), His tagged E.coli His Asn52-His258
Human HCFC1-3753H Recombinant Human HCFC1 protein, His-tagged E.coli His 1-350 aa
Mouse HCFC1-7514M Recombinant Mouse HCFC1 Protein Mammalian Cell His
Mouse HCFC1-4079M-B Recombinant Mouse HCFC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse HCFC1-4079M Recombinant Mouse HCFC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hcfc1-408M Recombinant Mouse Hcfc1 Protein, His-tagged E.coli His Ser107~Thr332
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HCFC1 Related Articles

HCFC1 involved in several pathways and played different roles in them. We selected most pathways HCFC1 participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCFC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Herpes simplex infectionHLA-DOB;SRSF9;MHC2A;TAF3;HLA-B;PER1B;MAPK8B;C3A.2;HCFC1A

HCFC1 has several biochemical functions, for example, chromatin binding, contributes_to histone acetyltransferase activity (H4-K16 specific), contributes_to histone acetyltransferase activity (H4-K5 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by HCFC1 itself. We selected most functions HCFC1 had, and list some proteins which have the same functions with HCFC1. You can find most of the proteins on our site.

Function Related Protein
chromatin bindingWHSC1;TDRD3;KLF14;ZFP932;NIPBL;PBRM1;JARID2;MEF2A;KLHDC3
contributes_to histone acetyltransferase activity (H4-K16 specific)HCFC1;KANSL3;OGT;KAT8;KIAA1267;MCRS1;KANSL2;PHF20B
contributes_to histone acetyltransferase activity (H4-K5 specific)KANSL2;PHF20B;KANSL3;KAT8;KIAA1267;OGT;MCRS1;HCFC1
contributes_to histone acetyltransferase activity (H4-K8 specific)KANSL3;KIAA1267;KANSL2;OGT;KAT8;HCFC1;MCRS1;PHF20B
identical protein bindingRABAC1;DHX8;SCHIP1;LCP1;CLDN20;SNX33;TRA@;PFKL;ADIPOQ
protein bindingARMCX5;NOL6;LARP7;CFH;C9orf16;SDHAF2;SYCE3;GSE1;LILRB2
transcription coactivator activityTADA2A;ACTL6A;AIP;SETD3;USP16;MYOD1;SMARCC2;MTF1;BCL10
transcription factor activity, sequence-specific DNA bindingZKSCAN3;SMAD3A;ZNF490;CDX1B;GTF2I;PRDM2;TFCP2L1;ATOH1;FOXC1B
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingREL;POU4F1;NFATC1;SUB1;MEOX2;HMGA1;SFPI1;NFE2L2;HCFC1

HCFC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCFC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCFC1.

CREBZF; CREB3; OGT

Mohan, GS; Ye, L; et al. Less Is More: Ebola Virus Surface Glycoprotein Expression Levels Regulate Virus Production and Infectivity. JOURNAL OF VIROLOGY 89:1205-1217(2015).
Gehring, G; Rohrmann, K; et al. The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 69:2123-2131(2014).
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