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HCST

  • Official Full Name

    hematopoietic cell signal transducer

  • Overview

    This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
  • Synonyms

    HCST; hematopoietic cell signal transducer; phosphoinositide 3 kinase adaptor protein , PIK3AP; DAP10; DKFZP586C1522; DNAX activation protein 10; KAP10; kinase assoc pro of ~10kDa; Membrane protein DAP10; phosphoinositide 3 kinase adaptor protein; PIK3AP; Transmembrane adapter protein KAP10; kinase assoc protein; DNAX-activation protein 10; phosphoinositide-3-kinase adaptor protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • C
  • mFc
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HCST-130H Recombinant Human HCST, Fc tagged Human Cell His
Human HCST-781HCL Recombinant Human HCST cell lysate Human Cell N/A
Human HCST-1055H Recombinant Human HCST Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HCST-1309H Recombinant Human HCST protein(Met1-Pro48), mFc-tagged HEK293 C-mFc Met1-Pro48
Mouse HCST-7525M Recombinant Mouse HCST Protein Mammalian Cell His
Mouse Hcst-3365M Recombinant Mouse Hcst Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HCST-4087M Recombinant Mouse HCST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HCST-4087M-B Recombinant Mouse HCST Protein Pre-coupled Magnetic Beads HEK293
Rat HCST-2813R Recombinant Rat HCST Protein Mammalian Cell His
Rat HCST-2468R-B Recombinant Rat HCST Protein Pre-coupled Magnetic Beads HEK293
Rat HCST-2468R Recombinant Rat HCST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HCST-2052R Recombinant Rhesus monkey HCST Protein, His-tagged Mammalian Cell His
Rhesus Macaque HCST-1873R Recombinant Rhesus Macaque HCST Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HCST-1873R-B Recombinant Rhesus Macaque HCST Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HCST-5872Z Recombinant Zebrafish HCST Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HCST Related Articles

HCST involved in several pathways and played different roles in them. We selected most pathways HCST participated on our site, such as Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemAP1B1;TRIM9;RNF19B;MOV10;DYNC1I2;DYNC1I1;NRG3;LILRB4;NPEPPS
Immune SystemAP1B1;RBCK1;TRIM5;TRAF7;RNF138;TRIM29;KIF15;KIF3C;CD300LG
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTREML1;SH2D1B;LAIR1;LILRB4;KLRG1;ICAM4;HCST;CLEC2B;TREM1
Natural killer cell mediated cytotoxicityLCK;IFNA10;TNFSF10;Ifna11;MAPK1;NFATC1;KLRC2;SH3BP2;HCST

HCST has several biochemical functions, for example, phosphatidylinositol 3-kinase binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HCST itself. We selected most functions HCST had, and list some proteins which have the same functions with HCST. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol 3-kinase bindingCALM2;ATP1A1;CALM3;FYN;TYRO3;FLT3;PIK3R1;IGF1RA;JAK2
protein bindingTMEM110;SCO1;MAT2B;ITGB4;NIP7;PFDN5;GAS7;ASCL1;FGF21
receptor bindingENSA;TGFB2;GFRA1;DIAPH1;CALCA;GUSB;CRTAM;PTK2AB;TAC1

HCST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCST here. Most of them are supplied by our site. Hope this information will be useful for your research of HCST.

KLRK1; katG

Penack, O; Fischer, L; et al. Serotherapy with thymoglobulin and alemtuzumab differentially influences frequency and function of natural killer cells after allogeneic stem cell transplantation. BONE MARROW TRANSPLANTATION 41:377-383(2008).
Wiendl, H; Lehmann, HC; et al. Multiple sclerosis: potential therapeutic options and update of ongoing clinical trials. NERVENARZT 75:536-+(2004).
Ishida, N; Ito, M; et al. Functional expression of human Golgi CMP sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant. JOURNAL OF BIOCHEMISTRY 124:171-178(1998).
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