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HDC

  • Official Full Name

    histidine decarboxylase

  • Overview

    This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.
  • Synonyms

    HDC; histidine decarboxylase; MGC163399;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDC-230H Recombinant Human HDC Mammalian Cell His
Human HDC-4654H Recombinant Human HDC Protein, GST-tagged Wheat Germ GST
Human HDC-5600HCL Recombinant Human HDC 293 Cell Lysate HEK293 N/A
Human HDC-495H Recombinant Human HDC Protein, His-tagged E.coli His Ala160~Phe369
Human HDC-3435HF Recombinant Full Length Human HDC Protein, GST-tagged In Vitro Cell Free System GST 662 amino acids
Human HDC-2110H Recombinant Human HDC Protein (1-662 aa), His-tagged Yeast His 1-662 aa
Human HDC-1057H Recombinant Human HDC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HDC-988HFL Recombinant Full Length Human HDC Protein, C-Flag-tagged Mammalian cells Flag
Human HDC-3070H Recombinant Human HDC Protein (Met2-Gln477), C-His tagged E.coli C-His Met2-Gln477
Human HDC-1057H-B Recombinant Human HDC Protein Pre-coupled Magnetic Beads HEK293
Human HDC-3071H Recombinant Human HDC Protein E.coli Tag Free
Mouse HDC-7536M Recombinant Mouse HDC Protein Mammalian Cell His
Mouse HDC-4094M Recombinant Mouse HDC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hdc-1105M Recombinant Mouse Hdc Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Hdc-496M Recombinant Mouse Hdc Protein, His-tagged E.coli His Tyr341~Ser597
Mouse HDC-4094M-B Recombinant Mouse HDC Protein Pre-coupled Magnetic Beads HEK293
Rat Hdc-497R Recombinant Rat Hdc Protein, His-tagged E.coli His Leu365~Gly643
Zebrafish HDC-5929Z Recombinant Zebrafish HDC Mammalian Cell His
Chicken HDC-5573C Recombinant Chicken HDC Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HDC Related Articles

HDC involved in several pathways and played different roles in them. We selected most pathways HDC participated on our site, such as Histidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Histidine metabolismALDH3B1;HAL;ALDH2;ALDH3B2;HDC;ABP1;ALDH2.2;UROC1;ALDH9A1B
Metabolic pathwaysGALNTL5;CYP11C1;NMRK2;AGPAT6;SDSL;AOX4;HYAL1;PIK3C2G;IMPAD1

HDC has several biochemical functions, for example, histidine decarboxylase activity, protein binding, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDC itself. We selected most functions HDC had, and list some proteins which have the same functions with HDC. You can find most of the proteins on our site.

Function Related Protein
histidine decarboxylase activity
protein bindingTRIM13;FAM151B;HIST1H2BI;SCAMP1;FZD2;GSDMA2;PKM;KIAA1109;SYCE3
pyridoxal phosphate bindingCTHL;SPTLC1;THNSL2;CCBL2;GAD1;AGXT2L1;PYGMA;GOT2A;OAT

HDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDC here. Most of them are supplied by our site. Hope this information will be useful for your research of HDC.

DTX2; DTX2

Schneider, EH; Neumann, D; et al. Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 47:101-121(2014).
Caro-Astorga, J; Fajardo, I; et al. Nascent histamine induces alpha-synuclein and caspase-3 on human cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:580-586(2014).
  • Q&As
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