F9
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Official Full Name
coagulation factor IX
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Overview
Factor IX (or Christmas factor) (EC 3.4.21.22) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered in 1952 after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia. -
Synonyms
coagulation facto; F9; FIX; P19; PTC; HEMB; MGC129641; MGC129642; coagulation factor IX; FIX F9; factor 9; Christmas factor; OTTHUMP00000024154; plasma thromboplastic component;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Chicken
- Cynomolgus
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- Vaccinia virus (strain L-IVP) (VACV)
- E.coli
- E.coli expression system
- HEK293
- Human
- Human Cell
- Human Plasma
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Mouse Plasma
- Plasma
- Wheat Germ
- C
- His
- Fc
- GST
- hFc
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- F9 Related Articles
F9 involved in several pathways and played different roles in them. We selected most pathways F9 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with F9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | C6;CFI;C8B;BDKRB1;SERPINE1;Serpina1b;SERPINA1A;CFB;SERPINA1 |
F9 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by F9 itself. We selected most functions F9 had, and list some proteins which have the same functions with F9. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | ANXA7;ANXA4;CALUA;THBD;MYLPFA;PCDH2AA1;MMP14B;CIB1;SCUBE3 |
endopeptidase activity | MMP1A;KLK1B4;MMP12;PSMB8F;TRAPPC12;PSMB2;PSMB7;KLK1B24;KLK1B9 |
serine-type endopeptidase activity | PRSS59.2;Prss32;C1rb;KLK1B8;PRSS1;KLK1;KLK5;PCSK9;PIK3IP1 |
F9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with F9 here. Most of them are supplied by our site. Hope this information will be useful for your research of F9.
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- Q&As
- Reviews
Q&As (6)
Ask a questionThe F9 protein is involved in step IX in the coagulation cascade, which works synergistically with other coagulation factors to promote the normal progress of blood clotting.
Mutations in the F9 gene may lead to loss of protein expression, structural abnormalities, or dysfunction, which in turn affect the normal function of the F9 protein.
F9 protein mutations are primarily associated with hemophilia B, but the specific mutation type and location may have different effects on an individual's clinical presentation.
Mutations in the F9 gene may cause hemophilia B, an inherited coagulation disorder in which patients lack the F9 protein or have low activity and are prone to abnormal bleeding.
The activity of the F9 protein is usually measured by coagulation time or by specific experimental methods (eg, prothrombin time, activated partial thromboplastin time, etc.).
F9 protein is a single-chain glycoprotein consisting of 415 amino acids. It contains a signaling peptide and multiple functional regions in which the Gla domain at the C-terminal binds to calcium ions and the EGF-like domain at the N-terminus participates in receptor binding and activation.
Customer Reviews (3)
Write a reviewThe short half-life makes this product very safe.
This protein has a wide range of applications and can be used in a variety of experiments.
The method of use is simple, which reduces the experimental time and improves the efficiency.
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