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HERC2

  • Official Full Name

    hect domain and RLD 2

  • Overview

    This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability.
  • Synonyms

    HERC2; hect domain and RLD 2; E3 ubiquitin-protein ligase HERC2; D15F37S1; jdf2; p528; HECT domain and RCC1 like domain containing protein 2; SHEP1; probable E3 ubiquitin-protein ligase HERC2; hect domain and RCC1-like domain-containing protein 2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HERC2-0433H Recombinant Human HERC2 Protein (S3951-P4321), His tagged E.coli His S3951-P4321
Human HERC2-0432H Recombinant Human HERC2 Protein (S3951-P4321), Tag Free E.coli No tag S3951-P4321
Mouse HERC2-7580M Recombinant Mouse HERC2 Protein Mammalian Cell His
Mouse HERC2-4127M Recombinant Mouse HERC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HERC2-4127M-B Recombinant Mouse HERC2 Protein Pre-coupled Magnetic Beads HEK293
Chicken HERC2-4573C Recombinant Chicken HERC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HERC2 Related Articles

HERC2 involved in several pathways and played different roles in them. We selected most pathways HERC2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisNEDD4L;FZR1A;SIAH2L;PRPF19;UBE2S;BIRC7;UBE2E2;SMURF1;RCHY1

HERC2 has several biochemical functions, for example, SUMO binding, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC2 itself. We selected most functions HERC2 had, and list some proteins which have the same functions with HERC2. You can find most of the proteins on our site.

Function Related Protein
SUMO bindingTOLLIP;PML;RPS3;HERC2;CBX4;USPL1;USP25;TDG
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activityTRIM41;TMEM129;LTN1;RNF144AB;MARCH11;TRIM50;RNF180;HECW2;ZNRF3
coenzyme F420-0 gamma-glutamyl ligase activityHERC2;ZNRF3;MUL1A;NEURL3;RNF144AB;MARCH11;RNF180;G2E3;TRIM71
coenzyme F420-2 alpha-glutamyl ligase activityTMEM129;TRIM50;MARCH5L;RNF149;DTX1;RC3H2;MYLIPB;MUL1A;RNF169
ligase activityTRIM41;HECTD1;UFL1;HECW1;UBE3C;MARCH3;RNF169;SH3RF2;ZNRF1
metal ion bindingTGFBR1;B3GAT2;TIPARP;BMPR1A;COL1A2;ACAP1;CD209A;COX4I2;IMPDH2
protein-glutamic acid ligase activityMARCH11;ARIH1L;SIAH2L;TRIM71;HECW2;G2E3;NEURL3;RNF149;ZNRF2B
protein-glycine ligase activityZNRF2B;MARCH11;ITCHA;NEURL3;ARIH1L;RAG1;RNF144AB;HERC2;UBR1
protein-glycine ligase activity, elongatingNEURL1B;MUL1A;TMEM129;LTN1;RNF144AB;TRIM71;NEURL3;G2E3;DTX1
protein-glycine ligase activity, initiatingRNF169;SHRPRBCK1R;RAG1;RNF149;TRIM41;ZNRF3;RFWD2;TMEM129;SIAH1A
ribosomal S6-glutamic acid ligase activityTRIM50;HECW2;NEURL3;HERC2;UBE2IB;MYLIPA;RNF144AB;UBE2M;ITCHA
tubulin-glutamic acid ligase activitySHRPRBCK1R;DTX1;LTN1;HECW2;ZNRF3;MGRN1A;UBE2IB;HERC2;TRIM41
tubulin-glycine ligase activityMYLIPB;TMEM129;G2E3;MARCH4;SIAH1A;TRIM41;HERC2;UBR1;SHRPRBCK1R
ubiquitin protein ligase activityUBR5;TRIM71;HERC6;PDZRN3B;RAD18;RNF222;HECTD1;TRIM24;TRIP12
ubiquitin protein ligase bindingDBT;CASC3;POLR2A;GABARAPL1;STUB1;UBE2U;UBE2K;KCNQ3;MID1
ubiquitin-protein transferase activityFBXO30A;CBLB;ARIH1L;TRIM33;BRCA1;UBE2C;HECW2;ZYG11;LNX2B
zinc ion bindingLMO7A;ZDHHC3B;SIRT3;CPA1;NR2F6;PCGF6;PAPLNB;CPA5;PGLYRP3

HERC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC2.

NEURL4; ZBTB5; SSSCA1; SFN; ESCO1

Moroishi, T; Yamauchi, T; et al. HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16430-16441(2014).
Long, Y; Wang, YB; et al. Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice. PLOS ONE 8:-(2013).
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