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HERC3

  • Official Full Name

    HECT and RLD domain containing E3 ubiquitin protein ligase 3

  • Overview

    HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).
  • Synonyms

    HERC3; HECT and RLD domain containing E3 ubiquitin protein ligase 3; hect domain and RLD 3; probable E3 ubiquitin-protein ligase HERC3; KIAA0032; HECT domain and RCC1-like domain-containing protein 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HERC3-13738H Recombinant Human HERC3, GST-tagged E.coli GST 1-368a.a.
Human HERC3-4691H Recombinant Human HERC3 Protein, GST-tagged Wheat Germ GST
Human HERC3-780HCL Recombinant Human HERC3 cell lysate N/A
Rhesus Macaque HERC3-2067R Recombinant Rhesus monkey HERC3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HERC3-1888R-B Recombinant Rhesus Macaque HERC3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HERC3-1888R Recombinant Rhesus Macaque HERC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HERC3-7363Z Recombinant Zebrafish HERC3 Mammalian Cell His
Chicken HERC3-3358C Recombinant Chicken HERC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HERC3 involved in several pathways and played different roles in them. We selected most pathways HERC3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisSMURF2;UBE2D2;UBE4A;CUL1B;PIAS4;CDH1-A;MGRN1;UBA6;SOCS1

HERC3 has several biochemical functions, for example, ligase activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC3 itself. We selected most functions HERC3 had, and list some proteins which have the same functions with HERC3. You can find most of the proteins on our site.

Function Related Protein
ligase activityPIAS1;TRIM8;UBE3C;PIAS3;RNF31;PCXA;PRP19;RNF144AB;TRIM69
ubiquitin protein ligase activitySMURF2;NHLRC1;ITCHA;UBE2KB;HECW1;UBE2O;UBE2J1;RNF13;TRIM24

HERC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC3.

UBC; CCL22; TK1; CD33

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