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HERC4

  • Official Full Name

    hect domain and RLD 4

  • Overview

    HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).
  • Synonyms

    HERC4; hect domain and RLD 4; probable E3 ubiquitin-protein ligase HERC4; DKFZP564G092; KIAA1593; HECT domain and RCC1 like domain containing protein 4; HECT domain and RCC1-like domain-containing protein 4; HERC 4; HERC4_HUMAN; Probable E3 ubiquitin protein ligase HERC4; OTTHUMP00000019692; OTTHUMP00000019693; OTTHUMP00000217539; OTTHUMP00000217540;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HERC4-637H Active Recombinant Human HERC4 Protein, GST-tagged Insect Cell GST 642-end
Human HERC4-178H Recombinant Human HERC4, GST-tagged Sf9 Insect Cell GST
Human HERC4-13739H Recombinant Human HERC4, GST-tagged E.coli GST 723-1049a.a.
Human HERC4-4692H Recombinant Human HERC4 Protein, GST-tagged Wheat Germ GST
Mouse HERC4-7582M Recombinant Mouse HERC4 Protein Mammalian Cell His
Mouse HERC4-4128M Recombinant Mouse HERC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HERC4-4128M-B Recombinant Mouse HERC4 Protein Pre-coupled Magnetic Beads HEK293
Rat HERC4-2827R Recombinant Rat HERC4 Protein Mammalian Cell His
Rat HERC4-2482R Recombinant Rat HERC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HERC4-2482R-B Recombinant Rat HERC4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HERC4-2068R Recombinant Rhesus monkey HERC4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HERC4-1889R Recombinant Rhesus Macaque HERC4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HERC4-1889R-B Recombinant Rhesus Macaque HERC4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HERC4 Related Articles

HERC4 involved in several pathways and played different roles in them. We selected most pathways HERC4 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisFBXW11A;UBE4A;SMURF2;PIAS4;XIAP;ANAPC4;TRIP12;TRIM37;UBE2NA

HERC4 has several biochemical functions, for example, ligase activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC4 itself. We selected most functions HERC4 had, and list some proteins which have the same functions with HERC4. You can find most of the proteins on our site.

Function Related Protein
ligase activityRNF217;MGRN1A;UBE2L3B;SIAH2;TMEM129;PPIL2;HERC2;NEDD4;PIAS4
ubiquitin protein ligase activityRNF111;FBXW11;RNF144B;FBXO30;RBBP6;BFAR;CDK8;MYLIP;RNF220

HERC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC4.

HSP90AB1

Zhou, H; Shi, R; et al. The expression and clinical significance of HERC4 in breast cancer. CANCER CELL INTERNATIONAL 13:-(2013).
Imami, K; Bhavsar, AP; et al. Global Impact of Salmonella Pathogenicity Island 2-secreted Effectors on the Host Phosphoproteome. MOLECULAR & CELLULAR PROTEOMICS 12:1632-1643(2013).
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