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HES6

  • Official Full Name

    hes family bHLH transcription factor 6

  • Overview

    This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
  • Synonyms

    HES6; hes family bHLH transcription factor 6; HES-6; bHLHb41; bHLHc23; C-HAIRY1; transcription cofactor HES-6; hairy and enhancer of split 6; class B basic helix-loop-helix protein 41;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HES6-4706H Recombinant Human HES6 Protein, GST-tagged Wheat Germ GST
Human HES6-13748H Recombinant Human HES6, His-tagged E.coli His 1-224a.a.
Human HES6-5580HCL Recombinant Human HES6 293 Cell Lysate HEK293 N/A
Human HES6-3520HF Recombinant Full Length Human HES6 Protein, GST-tagged In Vitro Cell Free System GST 224 amino acids
Mouse HES6-7590M Recombinant Mouse HES6 Protein Mammalian Cell His
Mouse HES6-4135M-B Recombinant Mouse HES6 Protein Pre-coupled Magnetic Beads HEK293
Mouse HES6-4135M Recombinant Mouse HES6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hes6-3387M Recombinant Mouse Hes6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish HES6-9750Z Recombinant Zebrafish HES6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HES6 Related Articles

HES6 involved in several pathways and played different roles in them. We selected most pathways HES6 participated on our site, such as Delta-Notch Signaling Pathway, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with HES6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Delta-Notch Signaling PathwayHEY2;CNTN1B;YY1;ZFPM1;SMAD3B;NOV;ADAM10A;JAG2;MAGEA1
Notch-mediated HES/HEY networkRCAN1;MYOD1;GATA1;YY1;CTBP1;GATA6;HES6;BGLAP;HEY1

HES6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, protein dimerization activity, transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HES6 itself. We selected most functions HES6 had, and list some proteins which have the same functions with HES6. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingCSDA;ZGLP1;HSF2;PHOX2A;ZNF583;RORA;ETV3;IKZF3;DMRT1
protein dimerization activityLMLN;ID4;TFEB;HER4.3;SIM1A;BETA3;FIGLA;NPAS4;MGAA
transcription cofactor activityNMI;ZNF212;MED1;MED4;SUPT20H;NSD1;PHF21B;POU2AF1;NRG1
transcription factor activity, sequence-specific DNA bindingZNF396;MTA2;SPI1A;PA2G4B;ZFP13;RUNX1;HDAC1;SIX3;EGR1
transcription factor bindingTP53;TRERF1;BCOR;NBN;DACT2;HES2;PIK3R1;NKX3;ERCC3
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingBCL6AB;ARID5B;VAX1;NFKB1;ZNF350;SNAI3;CGGBP1;HES6;CSDA

HES6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES6.

TWIST1

Schroter, C; Ares, S; et al. Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit. PLOS BIOLOGY 10:-(2012).
Son, YS; Park, JH; et al. Heat shock 70-kDa protein 8 isoform 1 is expressed on the surface of human embryonic stem cells and downregulated upon differentiation. STEM CELLS 23:1502-1513(2005).
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