HES6
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Official Full Name
hes family bHLH transcription factor 6
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Overview
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008] -
Synonyms
HES6; hes family bHLH transcription factor 6; HES-6; bHLHb41; bHLHc23; C-HAIRY1; transcription cofactor HES-6; hairy and enhancer of split 6; class B basic helix-loop-helix protein 41;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | HES6-4706H | Recombinant Human HES6 Protein, GST-tagged | Wheat Germ | GST | ||
Human | HES6-13748H | Recombinant Human HES6, His-tagged | E.coli | His | 1-224a.a. | |
Human | HES6-5580HCL | Recombinant Human HES6 293 Cell Lysate | HEK293 | N/A | ||
Human | HES6-3520HF | Recombinant Full Length Human HES6 Protein, GST-tagged | In Vitro Cell Free System | GST | 224 amino acids | |
Mouse | HES6-7590M | Recombinant Mouse HES6 Protein | Mammalian Cell | His | ||
Mouse | HES6-4135M-B | Recombinant Mouse HES6 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | HES6-4135M | Recombinant Mouse HES6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Hes6-3387M | Recombinant Mouse Hes6 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Zebrafish | HES6-9750Z | Recombinant Zebrafish HES6 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- HES6 Related Articles
HES6 involved in several pathways and played different roles in them. We selected most pathways HES6 participated on our site, such as Delta-Notch Signaling Pathway, Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with HES6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Delta-Notch Signaling Pathway | HEY2;CNTN1B;YY1;ZFPM1;SMAD3B;NOV;ADAM10A;JAG2;MAGEA1 |
Notch-mediated HES/HEY network | RCAN1;MYOD1;GATA1;YY1;CTBP1;GATA6;HES6;BGLAP;HEY1 |
HES6 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, protein dimerization activity, transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HES6 itself. We selected most functions HES6 had, and list some proteins which have the same functions with HES6. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II regulatory region sequence-specific DNA binding | CSDA;ZGLP1;HSF2;PHOX2A;ZNF583;RORA;ETV3;IKZF3;DMRT1 |
protein dimerization activity | LMLN;ID4;TFEB;HER4.3;SIM1A;BETA3;FIGLA;NPAS4;MGAA |
transcription cofactor activity | NMI;ZNF212;MED1;MED4;SUPT20H;NSD1;PHF21B;POU2AF1;NRG1 |
transcription factor activity, sequence-specific DNA binding | ZNF396;MTA2;SPI1A;PA2G4B;ZFP13;RUNX1;HDAC1;SIX3;EGR1 |
transcription factor binding | TP53;TRERF1;BCOR;NBN;DACT2;HES2;PIK3R1;NKX3;ERCC3 |
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | BCL6AB;ARID5B;VAX1;NFKB1;ZNF350;SNAI3;CGGBP1;HES6;CSDA |
HES6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HES6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HES6.
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