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HGD

  • Official Full Name

    homogentisate 1,2-dioxygenase

  • Overview

    This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.
  • Synonyms

    HGD; homogentisate 1,2-dioxygenase; AKU, homogentisate 1,2 dioxygenase (homogentisate oxidase); HGO; homogentisate oxidase; AKU; Homogentisate 1 2 dioxygenase; Homogentisic acid oxidase; Homogentisicase; homogentisate oxygenase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HGD-4723H Recombinant Human HGD Protein, GST-tagged Wheat Germ GST
Human HGD-256H Recombinant Human HGD Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HGD-1174H Recombinant Human HGD protein, His-tagged E.coli His Val239~Glu428 (Accession # Q93099)
Human HGD-5571HCL Recombinant Human HGD 293 Cell Lysate HEK293 N/A
Human HGD-3531HF Recombinant Full Length Human HGD Protein, GST-tagged In Vitro Cell Free System GST 329 amino acids
Human HGD-2350H Recombinant Human HGD Protein (Ser8-Gly205), N-His tagged E.coli N-His Ser8-Gly205
Human HGD-1475HFL Recombinant Full Length Human HGD Protein, C-Flag-tagged Mammalian cells Flag
Human HGD-3569H Recombinant Human HGD protein, His-tagged E.coli His 1-329 aa
Human HGD-1066H Recombinant Human HGD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HGD-6707H Recombinant Human HGD Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HGD-1622H Recombinant Human HGD Protein, His&GST-tagged E.coli N-His&GST Ser8-Glu428
Human HGD-4685H Recombinant Human HGD protein, His-tagged E.coli His 1-445aa
Human HGD-1066H-B Recombinant Human HGD Protein Pre-coupled Magnetic Beads HEK293
Mouse HGD-7604M Recombinant Mouse HGD Protein Mammalian Cell His
Mouse Hgd-1175M Recombinant Mouse Hgd protein, His & T7-tagged E.coli His/T7 Val190~Pro429 (Accession # O09173)
Mouse HGD-4146M Recombinant Mouse HGD Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HGD-4146M-B Recombinant Mouse HGD Protein Pre-coupled Magnetic Beads HEK293
Mouse Hgd-1121M Recombinant Mouse Hgd Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish HGD-9432Z Recombinant Zebrafish HGD Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HGD Related Articles

HGD involved in several pathways and played different roles in them. We selected most pathways HGD participated on our site, such as Tyrosine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Tyrosine metabolismTPO;FAH;ALDH3B1;AOX1;TAT;HPDB;GOT2A;FAHD1;TYR
Metabolic pathwaysGPIB;PON2;ACAA1A;OGDHL;COQ6;PHGDH;AGPAT3;PAFAH1B3;DGKD

HGD has several biochemical functions, for example, homogentisate 1,2-dioxygenase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGD itself. We selected most functions HGD had, and list some proteins which have the same functions with HGD. You can find most of the proteins on our site.

Function Related Protein
homogentisate 1,2-dioxygenase activity
metal ion bindingCYP2K22;SPATA21;CALUB;KAT8;ZMYND19;XIRP2;NPAS2;IREB2;TNNI1
protein bindingOLR1;TRPS1;ZNF398;BRCC3;FAS;ID2;AEN;TFIP11;SMYD1

HGD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGD here. Most of them are supplied by our site. Hope this information will be useful for your research of HGD.

TERF1; Dlg4; CLDN7; GIT2; PCDHGC3

Thota, PN; Lee, HJ; et al. Risk Stratification of Patients With Barrett's Esophagus and Low-grade Dysplasia or Indefinite for Dysplasia. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 13:459-465(2015).
Picardo, SL; O'Brien, MP; et al. A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia. DISEASES OF THE ESOPHAGUS 28:121-126(2015).
  • Q&As
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