HGD
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Official Full Name
homogentisate 1,2-dioxygenase
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Overview
This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria. -
Synonyms
HGD; homogentisate 1,2-dioxygenase; AKU, homogentisate 1,2 dioxygenase (homogentisate oxidase); HGO; homogentisate oxidase; AKU; Homogentisate 1 2 dioxygenase; Homogentisic acid oxidase; Homogentisicase; homogentisate oxygenase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HGD Related Articles
HGD involved in several pathways and played different roles in them. We selected most pathways HGD participated on our site, such as Tyrosine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Tyrosine metabolism | TPO;FAH;ALDH3B1;AOX1;TAT;HPDB;GOT2A;FAHD1;TYR |
Metabolic pathways | GPIB;PON2;ACAA1A;OGDHL;COQ6;PHGDH;AGPAT3;PAFAH1B3;DGKD |
HGD has several biochemical functions, for example, homogentisate 1,2-dioxygenase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGD itself. We selected most functions HGD had, and list some proteins which have the same functions with HGD. You can find most of the proteins on our site.
Function | Related Protein |
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homogentisate 1,2-dioxygenase activity | |
metal ion binding | CYP2K22;SPATA21;CALUB;KAT8;ZMYND19;XIRP2;NPAS2;IREB2;TNNI1 |
protein binding | OLR1;TRPS1;ZNF398;BRCC3;FAS;ID2;AEN;TFIP11;SMYD1 |
HGD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGD here. Most of them are supplied by our site. Hope this information will be useful for your research of HGD.
TERF1; Dlg4; CLDN7; GIT2; PCDHGC3
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