hgd
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  • Official Full Name
  • homogentisate 1,2-dioxygenase
  • Background
  • This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.
  • Synonyms
  • HGD; homogentisate 1,2-dioxygenase; AKU, homogentisate 1,2 dioxygenase (homogentisate oxidase); HGO; homogentisate oxidase; AKU; Homogentisate 1 2 dioxygenase; Homogentisic acid oxidase; Homogentisicase; homogentisate oxygenase
Cat.#:HGD-256HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human HGD Protein, MYC/DDK-tagged
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Cat.#:HGD-4723HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HGD Protein, GST-tagged
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Cat.#:HGD-1174HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HGD protein, His-tagged
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Cat.#:Hgd-1175MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hgd protein, His & T7-tagged
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Cat.#:HGD-7604MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HGD Protein
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Cat.#:HGD-9432ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HGD
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Cat.#:HGD-5571HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HGD 293 Cell Lysate
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Involved Pathway

HGD involved in several pathways and played different roles in them. We selected most pathways HGD participated on our site, such as Tyrosine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HGD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tyrosine metabolism
TYRP1; GOT2; AOX3L1; HPD; TAT; ALDH3A1; IL4I1; ALDH3B2; MAOA; MIF
Metabolic pathways
CEPT1B; CMPK1; POLR2I; CYP2C8; POLR2EB; GUSB; COQ5; UCK1; ATP5E; PCYT1BB

Protein Function

HGD has several biochemical functions, for example, homogentisate 1,2-dioxygenase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HGD itself. We selected most functions HGD had, and list some proteins which have the same functions with HGD. You can find most of the proteins on our site.
Function
Related Protein
Function homogentisate 1,2-dioxygenase activity
Related Protein HGD
Function metal ion binding
Related Protein SMYD3; ASH2L; ELAC2; MPPED2; RAF1; RNF180; ZIK1; MARCH6; ACACA; Gh
Function protein binding
Related Protein C6; METTL9; TBC1D1; GMIP; CD81; CDON; RAC1; TRAFD1; TDGF1; PTPRR

Interacting Protein

HGD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HGD here. Most of them are supplied by our site. Hope this information will be useful for your research of HGD.
TERF1; Dlg4; CLDN7; GIT2; PCDHGC3

HGD Related Articles

Thota, PN; Lee, HJ; et al. Risk Stratification of Patients With Barrett's Esophagus and Low-grade Dysplasia or Indefinite for Dysplasia. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 13:459-465(2015).
Picardo, SL; O'Brien, MP; et al. A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia. DISEASES OF THE ESOPHAGUS 28:121-126(2015).