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HLA-DMA

  • Official Full Name

    major histocompatibility complex, class II, DM alpha

  • Overview

    HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
  • Synonyms

    HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA; really interesting new gene 6 protein; class II histocompatibility antigen, M alpha chain; DM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DMA-4836H Recombinant Human HLA-DMA Protein, GST-tagged Wheat Germ GST
Human HLA-DMA-27713TH Recombinant Human HLA-DMA Wheat Germ N/A 261 amino acids
Human HLA-DMA-13812H Recombinant Human HLA-DMA, GST-tagged E.coli GST 21-261a.a.
Human HLA-DMA-5499HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DMA-3561HF Recombinant Full Length Human HLA-DMA Protein, GST-tagged In Vitro Cell Free System GST 261 amino acids
Human HLA-DMA-4026H Recombinant Human HLA-DMA protein, His-tagged E.coli His 27-233aa
Human HLA-DMA-230HF Recombinant Full Length Human HLA-DMA Protein In Vitro Cell Free System 261 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein

HLA-DMA involved in several pathways and played different roles in them. We selected most pathways HLA-DMA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeSTX18;FCGR2C;ITGB1;MHC2DCB;ATP6V0B;HBL4;ATP6V0E2;FCGR1;CLEC7A
Cell adhesion molecules (CAMs)VCAN;CADM1;NLGN2A;NLGN4A;ALCAM;CD274;HLA-DQB1;NLGN2;ITGA8
Antigen processing and presentationCTSL1;HLA-DRB3;HLA-DRB1;HSP90AB1;KIR2DS5;KIR3DL1;TAP2;CD4;IFNG
Intestinal iLTBR;TGFB1;IL-15RA;CCR10;MAP3K14;BLA;ICOS;HLA-DMB;HLA-DRB1
ne network for IgA productionCXCL12;HLA-DQA1;HLA-DRB3;Il2;CCL28;CD80;CD86;PIGR;BMA2
Type I diabetes mellitusFASLG;HLA-DQA2;TNF;CPE;HLA-E;ICA1;HLA-DPB1;FAS;H2-AB1
LeishmaniasisPRKCB;IFNGR1;NCF4;HLA-DOA;H2-AB1;TLR4;MAPK3;NCF1;MAPK11
ToxoplasmosisMAP3K7;PIK3CB;TGFB1;IKBKG;TYK2;HLA-DQA1;MAPK1;Toxoplasma Gondii Microneme Protein MIC3;LAMB4
Staphylococcus aureus infectionC5;FCGR3B;FCGR4;ITGAL;MBL2;ITGAM;FCGR1;DSG1C;HLA-DQA2
TuberculosisCAMK2A;Ifna15;IFNGR2;RAF1;NOS2;HLA-DMA;STAT1;FCGR2A;H2-AA
Influenza AIFNA2;EIF2AK1;IRF7;PML;NXT2;RAE1;IFNGR1;CPSF4;IL18
HTLV-I infectionFOS;DVL2;VDAC1;FZD2;SLC25A5;NRAS;BAX;MYBL2;NFATC1
Herpes simplex infectionRELA;FADD;SRSF5;PVRL1B;SRSF5A;TLR2;SRSF5B;CLOCKA;NFKB1
AsthmaIL9;HLA-DRB5;HLA-DPB1;HLA-DOA;EPX;CD40LG;HLA-DRA;HLA-DRB3;HLA-DQA2
AutoiHLA-DOB;IFNA6;TG;HLA-DPA1;FASLG;CD80;IFNA2;HLA-F;FAS
ne thyroid diseaseIfna11;HLA-DRB5;TPO;HLA-DRA;H2-AA;HLA-DOB;IFNA21;HLA-DQA2;HLA-E
Inflammatory bowel disease (IBD)IL21;TLR2;IL12RB1;IFNGR1;TGFB1;Il23a;TNF;RORA;Il23a; Il12b
Systemic lupus erythematosusHIST1H3H;TRIM21;HIST1H2BO;HIST1H2AN;HIST3H2A;HIST1H2BF;FCGR1A;ACTN2;HLA-DRB5
Rheumatoid arthritisITGAL;TLR4;HLA-DRA;IL11;HLA-DRB1;CTLA4;FOS;CD80;TGFB2
Allograft rejectionHLA-DRB5;CD80;CD40;IL10;HLA-DOB;H2-AA;HLA-A;H2-Q10;HLA-DRB1
Graft-versus-host diseaseHLA-DMA;HLA-DRA;IFNG;GZMB;HLA-DQA1;HLA-DRB3;HLA-F;HLA-A;KIR2DL3
Viral myocarditisHLA-DMA;CCND1;RAC2;HLA-DRB1;CD40LG;H2-AB1;HLA-DQA2;HLA-DOB;EIF4G3

HLA-DMA has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DMA itself. We selected most functions HLA-DMA had, and list some proteins which have the same functions with HLA-DMA. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein complex bindingCD81;HLA-DOB;HLA-DMA;HLA-DMB;HLA-DRA;PKM2;HLA-DOA;MS4A1;HSP90AB1

HLA-DMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DMA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DMA.

HLA-DRB1; HLA-DMB

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does HLA-DMA relate to autoimmune diseases? 07/01/2020

Aberrant antigen presentation mediated by HLA-DMA has been implicated in autoimmune diseases, as it may lead to the presentation of self-antigens and the activation of autoreactive T cells.

How can HLA-DMA be a potential therapeutic target? 12/19/2019

Modulating HLA-DMA activity could be explored as a therapeutic strategy in conditions where immune dysregulation occurs, such as autoimmune diseases, by influencing antigen presentation.

How does HLA-DMA contribute to the adaptive immune response? 07/30/2018

HLA-DMA facilitates the loading of antigenic peptides onto MHC class II molecules, a process essential for the activation of CD4+ T cells and the adaptive immune response.

In transplantation, how does HLA-DMA impact graft acceptance or rejection? 11/10/2017

Understanding HLA-DMA's role is crucial in transplantation, as it affects the presentation of antigens from the graft, influencing the immune response and the likelihood of graft acceptance or rejection.

Are there genetic variations in HLA-DMA that can influence disease susceptibility? 09/18/2017

Genetic variations in the HLA-DMA gene may contribute to differences in antigen presentation and influence susceptibility to certain diseases, making it an area of interest in genetic studies.

Customer Reviews (3)

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Reviews
08/17/2021

    Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.

    06/20/2016

      Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.

      04/04/2016

        Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.

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