HLA-DMA
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Official Full Name
major histocompatibility complex, class II, DM alpha
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Overview
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. -
Synonyms
HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA; really interesting new gene 6 protein; class II histocompatibility antigen, M alpha chain; DM;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- E.coli
- HEK293
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | HLA-DMA-4836H | Recombinant Human HLA-DMA Protein, GST-tagged | Wheat Germ | GST |
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| Human | HLA-DMA-27713TH | Recombinant Human HLA-DMA | Wheat Germ | N/A | 261 amino acids |
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| Human | HLA-DMA-13812H | Recombinant Human HLA-DMA, GST-tagged | E.coli | GST | 21-261a.a. | |
| Human | HLA-DMA-5499HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | N/A |
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| Human | HLA-DMA-3561HF | Recombinant Full Length Human HLA-DMA Protein, GST-tagged | In Vitro Cell Free System | GST | 261 amino acids |
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| Human | HLA-DMA-4026H | Recombinant Human HLA-DMA protein, His-tagged | E.coli | His | 27-233aa |
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| Human | HLA-DMA-230HF | Recombinant Full Length Human HLA-DMA Protein | In Vitro Cell Free System | 261 amino acids |
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- Involved Pathway
- Protein Function
- Interacting Protein
HLA-DMA involved in several pathways and played different roles in them. We selected most pathways HLA-DMA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | ITGAV;TUBA7L;FCGR1;MBL1;ATP6V1D;THBS3;CLEC7A;RAB5B;ABCB3L1 |
| Cell adhesion molecules (CAMs) | PVRL3B;CLDN1;MAG;CD226;SELE;GLYCAM1;ICOS;CLDNA;HLA-E |
| Antigen processing and presentation | Ctsl;KLRC3;HSPA1A;TAPBP;H2-AA;HSPA2;KIR2DS4;RFXAP;HLA-A |
| Intestinal i | HLA-DOB;LTBR;Il2;HLA-DRB5;HLA-DQA2;CCR10;CXCR4B;HLA-DOA;ITGB7 |
| ne network for IgA production | IL15;BLA;MHC2DCB;Icosl;BLB2;Il2;CCL27B;AICDA;H2-AA |
| Type I diabetes mellitus | H2-Q10;CD86;HLA-DOA;INS2;CD28;LTA;HLA-F;HLA-DPB1;HLA-DRB3 |
| Leishmaniasis | IRAK1;TNF;MAPK13;TGFB2;IL1B;MAPK1;NCF4;IRAK4;HLA-DMA |
| Toxoplasmosis | IL10RA;TYK2;AKT2;HLA-DRA;BIRC3;NFKBIB;MAPK8;LAMA4;MAP2K3 |
| Staphylococcus aureus infection | FPR1;FCGR1A;C5AR1;PTAFR;C2;H2-AB1;DSG1A;HLA-DRB4;HLA-DRB3 |
| Tuberculosis | BID;AKT1;Casp3;PPP3R2;ATP6V0A1;TLR4;CD209B;EEA1;Il23a |
| Influenza A | RAF1;LOC100686744;BMA1;TNF;FAS;DNAJB1;NXT2;PRSS1;NXT1 |
| HTLV-I infection | HLA-DMB;WNT7B;RRAS2;NFKB1;MAP2K4;MSX2;CDC16;PTTG2;ITGB2L |
| Herpes simplex infection | SRSF5;TAB2;HLA-DQA2;TAF6L;TLR2;CUL1;TNFRSF1A;IL15;C3A.3 |
| Asthma | IL3;HLA-DQA2;PRG2;HLA-DOA;FCER1G;CCL11;RNASE3;HLA-DRB3;FCER1A |
| Autoi | IFNA16;IFNA2;HLA-F;Ifna15;HLA-C;HLA-DOB;HLA-DPB1;IFNA4;HLA-DRA |
| ne thyroid disease | HLA-DRB3;HLA-DRB4;PRF1;GZMB;IFNA12;HLA-DQB1;IFNA7;IL5;IFNA8 |
| Inflammatory bowel disease (IBD) | HLA-DRA;HLA-DMB;IFNGR2;IL1B;SMAD2;TGFB2;TLR2;TGFB3;HLA-DRB1 |
| Systemic lupus erythematosus | HIST1H3D;HIST2H3C2;HIST1H2BC;HIST1H4N;FCGR1A;HIST1H2AJ;HIST1H2BJ;HIST2H2BE;HIST1H2BD |
| Rheumatoid arthritis | HLA-DQB1;IL1A;IL11;VEGFA;CXCL1;FLT1;FOS;ATP6V1B1;CD80 |
| Allograft rejection | IL4;HLA-DOA;CD80;H2-AB1;H2-Q10;Fasl;HLA-B;HLA-DRB3;HLA-F |
| Graft-versus-host disease | KLRC1;KLRD1;FASLG;H2-AB1;HLA-F;H2-Q10;KIR2DL1;HLA-DQB1;HLA-DRA |
| Viral myocarditis | RAC1;Casp3;HLA-DRB4;HLA-G;EIF4G3;HLA-DMA;CD40;HLA-C;MYH7 |
HLA-DMA has several biochemical functions, for example, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DMA itself. We selected most functions HLA-DMA had, and list some proteins which have the same functions with HLA-DMA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| MHC class II protein complex binding | CD81;PKM2;HLA-DMA;HSP90AA1;CD74;HLA-DOB;HSPA8;HSP90AB1;HLA-DRA |
HLA-DMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DMA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DMA.
HLA-DRB1; HLA-DMB
- Q&As
- Reviews
Q&As (5)
Ask a questionAberrant antigen presentation mediated by HLA-DMA has been implicated in autoimmune diseases, as it may lead to the presentation of self-antigens and the activation of autoreactive T cells.
Modulating HLA-DMA activity could be explored as a therapeutic strategy in conditions where immune dysregulation occurs, such as autoimmune diseases, by influencing antigen presentation.
HLA-DMA facilitates the loading of antigenic peptides onto MHC class II molecules, a process essential for the activation of CD4+ T cells and the adaptive immune response.
Understanding HLA-DMA's role is crucial in transplantation, as it affects the presentation of antigens from the graft, influencing the immune response and the likelihood of graft acceptance or rejection.
Genetic variations in the HLA-DMA gene may contribute to differences in antigen presentation and influence susceptibility to certain diseases, making it an area of interest in genetic studies.
Customer Reviews (3)
Write a reviewTheir in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.
Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.
Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.
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