HLA-DOA
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Official Full Name
major histocompatibility complex, class II, DO alpha
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Overview
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. -
Synonyms
HLA-DOA; major histocompatibility complex, class II, DO alpha; HLA DNA, HLA DZA; HLA class II histocompatibility antigen, DO alpha chain; HLA D0 alpha; HLA class II histocompatibility antigen, DO alpha chain precursor; HLA DNA; HLA DZA; HLADZ; Lymphocyte antigen; Major histocompatibility complex, class II, DN alpha; MHC class II antigen DOA; MHC DN alpha; MHC DZ alpha; HLA-D0-alpha; MHC DN-alpha; HLA-DNA; HLA-DZA;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HLA-DOA-4838H | Recombinant Human HLA-DOA Protein, GST-tagged | Wheat Germ | GST | ||
Human | HLA-DOA-232H | Recombinant Human major histocompatibility complex, class II, DO alpha, His-tagged | E.coli | His | ||
Human | HLA-DOA-13814H | Recombinant Human HLA-DOA, GST-tagged | E.coli | GST | 25-221a.a. | |
Human | HLA-DOA-5502HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-DOA Related Articles
HLA-DOA involved in several pathways and played different roles in them. We selected most pathways HLA-DOA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | LAMP2;ITGA5;STX7;ACTB;CTSLA;C1RA;CORO1A;RAB7B;CTSSB.1 |
Cell adhesion molecules (CAMs) | CLDNG;ITGAL;NRXN1A;ITGB1A;Itgam&Itgb2;CLDNE;CLDN11B;HLA-DQA1;ALCAM |
Antigen processing and presentation | CD8A;HLA-DQA2;HSPA5;HSPA1B;HLA-DOA;HSPA2;KLRC2;HSP90AA1;HSPA6 |
Intestinal i | HLA-DRB1;HLA-DRB4;TGFB1;CCL25;CXCR4;MHC2DEB;CD40LG;IL5;CD28 |
ne network for IgA production | ICOSLG;Icosl;BLA;IL15RA;BMA1;HLA-DOB;CD40;CCL25B;CD80 |
Type I diabetes mellitus | HLA-DQA2;HLA-G;HLA-DPB1;HLA-DPA1;FAS;HLA-C;CD86;HLA-B;HLA-DMA |
Leishmaniasis | HLA-DMB;HLA-DRB5;ITGB1;Itgam&Itgb2;CYBA;MARCKSL1;NCF1;HLA-DRB3;TGFB1 |
Toxoplasmosis | IL12A;ALOX5;PIK3R5;MAPK12;LAMA2;Toxoplasma Gondii Dense Granule Protein 7;IFNGR1;LAMC2;IRGM1 |
Staphylococcus aureus infection | PLG;FCGR3A;C1QC;C1R;FGG;HLA-DRB5;DSG1;Itgam&Itgb2;SELP |
Tuberculosis | IL6;CYCS;PPP3CB;MAPK13;HLA-DQA1;RFX5;FCGR3;ATP6V0C;PIK3C3 |
Influenza A | IFNB1;TLR7;TLR3;IFNA4;HLA-DRB3;HLA-DQB1;MAPK10;PRKCB;RELA |
HTLV-I infection | TBPL1;MYBL2;PRKACA;SLC25A6;AKT1;POLE;PPP3CB;TCF3;DLG1 |
Herpes simplex infection | FOS;IFNA1;SKP1;EIF2AK4;BF2;PKZ;H2-AB1;IFNA2;Ifna11 |
Asthma | IL13;IL3;EPX;MS4A2;CCL11;HLA-DQB1;CD40;H2-AB1;HLA-DPA1 |
Autoi | IL5;IFNA2;IL4;HLA-DPA1;PRF1;HLA-B;Il2;FAS;HLA-DOB |
ne thyroid disease | Ifna15;PRF1;HLA-DPB1;HLA-B;TPO;HLA-DMB;IFNA21;IFNA7;HLA-DRB4 |
Inflammatory bowel disease (IBD) | IFNG;STAT4;HLA-DRB1;HLA-DRB5;IL18R1;H2-AB1;IL4;FOXP3;HLA-DOB |
Systemic lupus erythematosus | C2;HIST1H2AP;HIST3H2BB-PS;TRIM21;CD80;C1R;HIST1H4L;C7;GRIN2B |
Rheumatoid arthritis | IL15;GM-CSF;ATP6V0A1;ATP6V0A4;ATP6V1G2;CXCL6;Il23a;CXCL5;ACP5 |
Allograft rejection | CD40LG;Il2;HLA-DRB1;IL12A;CD80;MICA;FASLG;HLA-DOA;HLA-DQB1 |
Graft-versus-host disease | HLA-DRB5;HLA-DRA;HLA-B;HLA-DOB;FAS;FASLG;IL1A;HLA-DMA;GZMB |
Viral myocarditis | CD28;ITGB2L;ACTG1;RAC3;ITGAL;CCND1;Casp3;HLA-DOA;HLA-DRB1 |
HLA-DOA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOA itself. We selected most functions HLA-DOA had, and list some proteins which have the same functions with HLA-DOA. You can find most of the proteins on our site.
Function | Related Protein |
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MHC class II protein complex binding | PKM;MS4A1;HLA-DRA;HSP90AA1;HLA-DOB;HSPA8;CD81;HLA-DOA;HLA-DMA |
MHC class II receptor activity | HLA-DRA;KRT17;HLA-DQB1;HLA-DRB3;HLA-DOA;HLA-DRB1;HLA-DQA2;HLA-DPA1;HLA-DOB |
protein binding | SF3A1;PITPNM3;NUP62L;CPSF6;SPINK2;FZD7;TRIM28;FLOT1;RG9MTD1 |
HLA-DOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOA.
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