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HLA-DOA

  • Official Full Name

    major histocompatibility complex, class II, DO alpha

  • Overview

    HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
  • Synonyms

    HLA-DOA; major histocompatibility complex, class II, DO alpha; HLA DNA, HLA DZA; HLA class II histocompatibility antigen, DO alpha chain; HLA D0 alpha; HLA class II histocompatibility antigen, DO alpha chain precursor; HLA DNA; HLA DZA; HLADZ; Lymphocyte antigen; Major histocompatibility complex, class II, DN alpha; MHC class II antigen DOA; MHC DN alpha; MHC DZ alpha; HLA-D0-alpha; MHC DN-alpha; HLA-DNA; HLA-DZA;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DOA-4838H Recombinant Human HLA-DOA Protein, GST-tagged Wheat Germ GST
Human HLA-DOA-232H Recombinant Human major histocompatibility complex, class II, DO alpha, His-tagged E.coli His
Human HLA-DOA-13814H Recombinant Human HLA-DOA, GST-tagged E.coli GST 25-221a.a.
Human HLA-DOA-5502HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DOA Related Articles

HLA-DOA involved in several pathways and played different roles in them. We selected most pathways HLA-DOA participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DOA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeLAMP2;ITGA5;STX7;ACTB;CTSLA;C1RA;CORO1A;RAB7B;CTSSB.1
Cell adhesion molecules (CAMs)CLDNG;ITGAL;NRXN1A;ITGB1A;Itgam&Itgb2;CLDNE;CLDN11B;HLA-DQA1;ALCAM
Antigen processing and presentationCD8A;HLA-DQA2;HSPA5;HSPA1B;HLA-DOA;HSPA2;KLRC2;HSP90AA1;HSPA6
Intestinal iHLA-DRB1;HLA-DRB4;TGFB1;CCL25;CXCR4;MHC2DEB;CD40LG;IL5;CD28
ne network for IgA productionICOSLG;Icosl;BLA;IL15RA;BMA1;HLA-DOB;CD40;CCL25B;CD80
Type I diabetes mellitusHLA-DQA2;HLA-G;HLA-DPB1;HLA-DPA1;FAS;HLA-C;CD86;HLA-B;HLA-DMA
LeishmaniasisHLA-DMB;HLA-DRB5;ITGB1;Itgam&Itgb2;CYBA;MARCKSL1;NCF1;HLA-DRB3;TGFB1
ToxoplasmosisIL12A;ALOX5;PIK3R5;MAPK12;LAMA2;Toxoplasma Gondii Dense Granule Protein 7;IFNGR1;LAMC2;IRGM1
Staphylococcus aureus infectionPLG;FCGR3A;C1QC;C1R;FGG;HLA-DRB5;DSG1;Itgam&Itgb2;SELP
TuberculosisIL6;CYCS;PPP3CB;MAPK13;HLA-DQA1;RFX5;FCGR3;ATP6V0C;PIK3C3
Influenza AIFNB1;TLR7;TLR3;IFNA4;HLA-DRB3;HLA-DQB1;MAPK10;PRKCB;RELA
HTLV-I infectionTBPL1;MYBL2;PRKACA;SLC25A6;AKT1;POLE;PPP3CB;TCF3;DLG1
Herpes simplex infectionFOS;IFNA1;SKP1;EIF2AK4;BF2;PKZ;H2-AB1;IFNA2;Ifna11
AsthmaIL13;IL3;EPX;MS4A2;CCL11;HLA-DQB1;CD40;H2-AB1;HLA-DPA1
AutoiIL5;IFNA2;IL4;HLA-DPA1;PRF1;HLA-B;Il2;FAS;HLA-DOB
ne thyroid diseaseIfna15;PRF1;HLA-DPB1;HLA-B;TPO;HLA-DMB;IFNA21;IFNA7;HLA-DRB4
Inflammatory bowel disease (IBD)IFNG;STAT4;HLA-DRB1;HLA-DRB5;IL18R1;H2-AB1;IL4;FOXP3;HLA-DOB
Systemic lupus erythematosusC2;HIST1H2AP;HIST3H2BB-PS;TRIM21;CD80;C1R;HIST1H4L;C7;GRIN2B
Rheumatoid arthritisIL15;GM-CSF;ATP6V0A1;ATP6V0A4;ATP6V1G2;CXCL6;Il23a;CXCL5;ACP5
Allograft rejectionCD40LG;Il2;HLA-DRB1;IL12A;CD80;MICA;FASLG;HLA-DOA;HLA-DQB1
Graft-versus-host diseaseHLA-DRB5;HLA-DRA;HLA-B;HLA-DOB;FAS;FASLG;IL1A;HLA-DMA;GZMB
Viral myocarditisCD28;ITGB2L;ACTG1;RAC3;ITGAL;CCND1;Casp3;HLA-DOA;HLA-DRB1

HLA-DOA has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DOA itself. We selected most functions HLA-DOA had, and list some proteins which have the same functions with HLA-DOA. You can find most of the proteins on our site.

Function Related Protein
MHC class II protein complex bindingPKM;MS4A1;HLA-DRA;HSP90AA1;HLA-DOB;HSPA8;CD81;HLA-DOA;HLA-DMA
MHC class II receptor activityHLA-DRA;KRT17;HLA-DQB1;HLA-DRB3;HLA-DOA;HLA-DRB1;HLA-DQA2;HLA-DPA1;HLA-DOB
protein bindingSF3A1;PITPNM3;NUP62L;CPSF6;SPINK2;FZD7;TRIM28;FLOT1;RG9MTD1

HLA-DOA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DOA here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DOA.

REL

Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).
Reynolds, RJ; Kelley, JM; et al. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population. GENES AND IMMUNITY 11:94-97(2010).
van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).
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