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HLA-DPA1

  • Official Full Name

    major histocompatibility complex, class II, DP alpha 1

  • Overview

    HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.
  • Synonyms

    T1; HLADP; HLASB; HLA-DP1A; HLA-DPA1; HLA class II histocompatibility antigen, DP alpha 1 chain; DP(W3); DP(W4); MHC class II DPA; HLA-SB alpha chain; OTTHUMP00000029066; MHC class II antigen; MHC class II DP3-alpha; Primed lymphocyte test-4; MHC class IIPA1 antigen; HLA class II histocompatibility antigen, DP alpha chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DPA1-13816H Recombinant Human HLA-DPA1, GST-tagged E.coli GST 32-224a.a.
Human HLA-DPA1-4840H Recombinant Human HLA-DPA1 Protein, GST-tagged Wheat Germ GST
Human HLA-DPA1-5506HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DPA1-5290H Recombinant Human HLA-DPA1 protein, His-tagged E.coli His 29-222aa
Human HLA-DPA1-3427H Recombinant Human HLA-DPA1 protein, His-tagged E.coli His 32-224 aa
Human HLA-DPA1-3582HF Recombinant Full Length Human HLA-DPA1 Protein, GST-tagged In Vitro Cell Free System GST 260 amino acids
Homo sapiens (Human) RFL26724HF Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dp Alpha 1 Chain(Hla-Dpa1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (29-260)
Zebrafish HLA-DPA1-5442Z Recombinant Zebrafish HLA-DPA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DPA1 Related Articles

HLA-DPA1 involved in several pathways and played different roles in them. We selected most pathways HLA-DPA1 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DPA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeATP6V1B1;CD36;ABCB3L1;ATP6V1C2;PIK3C3;ATP6V1C1A;ATP6V0C;ATP6V0E;ATP6AP1
Cell adhesion molecules (CAMs)CDH1;OCLN;ITGB7;ICAM2;CLDNJ;CLDNH;ITGA8;PVRL3B;NTNG1
Antigen processing and presentationHLA-DMA;CD8B;KIR2DS4;NFYA;HLA-DOA;Ctsl;CD8B1;HLA-DRB4;KIR3DL2
Intestinal iHLA-DRB4;BLA;IL15;CD28;CXCR4A;ICOS;H2-AB1;TGFB1A;HLA-DMB
ne network for IgA productionHLA-DQA2;CCL25;MHC2DAB;HLA-DQA1;HLA-DRB4;CD28;CXCL12B;BMA2;ICOS
Type I diabetes mellitusPRF1;HLA-DQB1;HLA-DRB3;IL12A;HLA-DMA;GAD2;H2-AA;TNF;HLA-DQA2
LeishmaniasisMAPK1;MAPK3;HLA-DOA;TGFB3;MAP3K7;HLA-DQA2;HLA-DPA1;NOS2;HLA-DRA
ToxoplasmosisHLA-DRB4;LAMC1;HLA-DPB1;MAPK10;LAMA5;MAP2K6;HLA-DRB3;MAPK11;Toxoplasma Gondii Profilin Family Protein
Staphylococcus aureus infectionDSG1A;C1QC;Hc;HLA-DRB3;MASP1;FCGR3;HLA-DOA;C3;C1QA
TuberculosisVDR;HLA-DPA1;CALM1;IFNA5;TGFB1;HLA-DQA2;CYCS;NFKB1;TGFB2
Influenza AIFNA12;IFNA2;PIK3R5;LOC100033925;IFNA5;NUP98;IL-8;STAT2;PRSS1
HTLV-I infectionNFKB2;ANAPC5;STAT5B;PPP3R1;FZD6;TGFBR1;MAP2K4;WNT8B;RRAS
Herpes simplex infectionPKZ;TRAF2;PPP1CC;BLB1;BMA1;EIF2AK1;HMGN1;TYK2;TAF3
Epstein-Barr virus infectionPSMD13;IRF3;ENTPD8;PSMD6;PSMD2;NFKB2;MAPK8;HLA-DQA2;TRADD
AsthmaHLA-DOA;H2-AB1;HLA-DRB1;FCER1A;HLA-DRA;HLA-DRB4;CD40LG;HLA-DOB;PRG2
AutoiIFNA16;TPO;HLA-DPB1;GZMB;HLA-E;CD86;Ifna11;HLA-DRB4;IL4
ne thyroid diseaseIFNA17;HLA-A;CD40LG;HLA-DRB4;CD40;IFNA2;Il2;IFNA16;HLA-B
Inflammatory bowel disease (IBD)STAT4;IL21R;H2-AB1;TNF;STAT3;HLA-DRB3;GATA3;HLA-DOB;IL22
Systemic lupus erythematosusHIST1H3F;HIST1H2BA;HIST1H2AM;SNRPB;FCGR3B;HLA-DPA1;HIST1H4I;TROVE2;HIST1H2AD
Rheumatoid arthritisCCL3;IL1A;IL23;ATP6V1A;IL17A;TNF;HLA-DPA1;IFNG;IL11
Allograft rejectionHLA-DRB3;CD80;HLA-DRB1;CD40;IL5;MICA;HLA-DRB4;IL12B;HLA-DQA2
Graft-versus-host diseaseHLA-DOA;FAS;HLA-B;HLA-DQA2;GZMB;KIR2DL3;TNF;IFNG;Fasl
Viral myocarditisCD40;EIF4G3;CD80;ITGB2L;FYN;HLA-DPB1;CXADR;HLA-DOA;HLA-DMA

HLA-DPA1 has several biochemical functions, for example, MHC class II receptor activity, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DPA1 itself. We selected most functions HLA-DPA1 had, and list some proteins which have the same functions with HLA-DPA1. You can find most of the proteins on our site.

Function Related Protein
MHC class II receptor activityHLA-DQB2;KRT17;HLA-DOB;HLA-DRB3;HLA-DRB4;HLA-DQA1;HLA-DRB1;HLA-DPA1;HLA-DRA
peptide antigen bindingMHC1UBA;MHC1UIA;HLA-A;MR1;HLA-DRB1;H2-AB1;HLA-DQB1;MHC1ZKA;HLA-DRB3

HLA-DPA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DPA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DPA1.

CD74; prfC; q7ard3_yerpe; iucD; q7chc4_yerpe

Gan, SJ; Ye, B; et al. Immune- and Ribosome-Related Genes were Associated with Systemic Vasculitis. SCANDINAVIAN JOURNAL OF IMMUNOLOGY 81:96-101(2015).
Ollila, HM; Ravel, JM; et al. HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy. AMERICAN JOURNAL OF HUMAN GENETICS 96:136-146(2015).
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