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HLA-DQA2

Official Full Name

major histocompatibility complex, class II, DQ alpha 2
Overview

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
Synonyms

HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2; HLA DXA; HLA class II histocompatibility antigen, DQ alpha 2 chain; HLA-DQA1; DX alpha chain; MHC class II DQA2; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DXA; DX-ALPH;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-DQA2-5494HCL	Recombinant Human HLA 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HLA-DQA2-1279H	Recombinant Human HLA-DQA2 Protein (24-214 aa), His-tagged	E.coli	His	24-214 aa	Inquiry
Homo sapiens (Human)	RFL35265HF	Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dq Alpha 2 Chain(Hla-Dqa2) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (24-255)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-DQA2 Related Articles
HLA-DQA2 Related Research Area

HLA-DQA2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA2 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phagosome	FCGR3B;HGS;BF2;TUBB2B;FCGR2C;ATP6V1B1;FCAR;RAC1A;CD36
Cell adhesion molecules (CAMs)	CLDN22;MPZ;HLA-DOA;CD34;ITGAL;ITGAV;SDC3;NFASC;SELE
Antigen processing and presentation	H2-AA;Ctsl;KIR3DL2;HLA-DQA2;KLRC1;KIR2DL3;HSPA1A;HLA-DRB4;PSME1
Intestinal i	HLA-DMB;MADCAM1;HLA-DQA2;MAP3K14;BMA1;IL6;MHC2DEB;HLA-DPB1;PIGR
ne network for IgA production	BMA1;MADCAM1;Il2;HLA-DQB1;CXCR4B;HLA-DMA;ITGB7;HLA-DQA1;IL5
Type I diabetes mellitus	IL1A;HLA-DRB5;HLA-DOB;HLA-DQA1;HLA-DQB1;PTPRN2;CPE;HSPD1;HLA-E
Leishmaniasis	ITGB2;CR1;FOS;TLR2;HLA-DRB1;IRAK1;H2-AA;FCGR3B;RELA
Toxoplasmosis	HLA-DOB;Toxoplasma Gondii Profilin Family Protein;IKBKB;MAP2K6;CASP9;XIAP;HLA-DPB1;MAPK13;PIK3R3
Staphylococcus aureus infection	PLG;FPR1;Hc;FCGR1;HLA-DRB3;PTAFR;HLA-DOA;HLA-DPB1;cgr2b
Tuberculosis	MAPK1;Ifna11;SPHK1;Itgam&Itgb2;BCL10;IL10RA;RAB5C;HLA-DPB1;cgr2b
Influenza A	SOCS3;CXCL8;HLA-DMA;IL12A;HSPA1B;BMA1;HSPA8;ACTG1;TRIM25
HTLV-I infection	TERT;BAX;ELK1;CREM;PIK3CA;IL1R2;MYBL1;HLA-DQA1;POLE4
Herpes simplex infection	ALYREF;MAP3K7;MAPK8B;PER1;PPP1CAB;MHC2DEB;OAS2;SRPK1;PPP1CBL
Epstein-Barr virus infection	HLA-G;YWHAB;POLR2B;PSMD13;HSPB2;CCNA2;EP300;POLR3B;ITGAL
Asthma	HLA-DPB1;IL3;HLA-DRB4;HLA-DMB;TNF;HLA-DQA1;IL10;HLA-DRB3;H2-AB1
Autoi	HLA-F;Fasl;IL4;CD86;IFNA6;TPO;HLA-DPA1;FAS;TSHB
ne thyroid disease	Fasl;FAS;H2-Q10;HLA-F;TSHB;CD86;HLA-B;HLA-DRB3;IFNA1
Inflammatory bowel disease (IBD)	IL4;FOXP3;IL21R;IL4R;IFNG;HLA-DOA;TGFB3;IL17A;TLR4
Systemic lupus erythematosus	HIST1H4K;HIST1H4N;C3;HIST1H2AC;HIST1H2BN;HIST1H3C;HIST1H3H;GM14477;FCGR2A
Rheumatoid arthritis	IL6;HLA-DRB4;CD86;ATP6V0E1;ATP6V0A4;HLA-DRB1;ATP6V1C1;TNF;Il23a; Il12b
Allograft rejection	HLA-C;GZMB;HLA-DMA;CD40;IL10;HLA-DOB;TNF;HLA-DRB1;HLA-DRB3
Graft-versus-host disease	CD28;HLA-C;KIR2DL1;HLA-DPB1;HLA-DMB;Il2;HLA-DMA;IL6;HLA-DRB1
Viral myocarditis	HLA-DRB3;PRF1;CASP8;ITGAL;ACTB;HLA-A;BID;HLA-DQB1;HLA-DRB5

HLA-DQA2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA2 itself. We selected most functions HLA-DQA2 had, and list some proteins which have the same functions with HLA-DQA2. You can find most of the proteins on our site.

Function	Related Protein
MHC class II receptor activity	HLA-DOB;HLA-DQB2;HLA-DOA;HLA-DRA;HLA-DPA1;HLA-DQA1;HLA-DQA2;HLA-DQB1;HLA-DRB4

HLA-DQA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA2.

Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).

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