HLA-DQA2
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Official Full Name
major histocompatibility complex, class II, DQ alpha 2
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Overview
This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. -
Synonyms
HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2; HLA DXA; HLA class II histocompatibility antigen, DQ alpha 2 chain; HLA-DQA1; DX alpha chain; MHC class II DQA2; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DXA; DX-ALPH;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HLA-DQA2-5494HCL | Recombinant Human HLA 293 Cell Lysate | HEK293 | N/A | ||
Human | HLA-DQA2-1279H | Recombinant Human HLA-DQA2 Protein (24-214 aa), His-tagged | E.coli | His | 24-214 aa | |
Homo sapiens (Human) | RFL35265HF | Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dq Alpha 2 Chain(Hla-Dqa2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-255) |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-DQA2 Related Articles
- HLA-DQA2 Related Research Area
HLA-DQA2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA2 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | RAB7B;HLA-DMB;ATP6V0B;DYNC1LI1;C3;CANX;CD14;THBS4A;SCARB1 |
Cell adhesion molecules (CAMs) | MPZ;CLDN10A;PVRL2;NFASCA;PECAM1;CLDNK;NCAM1A;BLA;MADCAM1 |
Antigen processing and presentation | HLA-DPA1;HLA-DQB1;HLA-F;NFYB;TAPBP;KLRC1;HLA-DRB1;HLA-A;HLA-DOB |
Intestinal i | HLA-DRB5;HLA-DQA2;CD40;HLA-DRA;CD28;Icosl;CXCR4B;BMA2;MHC2DAB |
ne network for IgA production | TNFRSF17;IL15;HLA-DOB;IL4;HLA-DOA;HLA-DQA1;AICDA;MHC2DEB;H2-AB1 |
Type I diabetes mellitus | FASLG;CD80;GAD2;PRF1;HLA-DRB4;GAD1;HLA-DMA;TNF;H2-Q10 |
Leishmaniasis | CR1;ITGB2L;ITGB1;MAPK1;HLA-DRB1;MAP3K7;TAB2;FCGR1A;PTPN6 |
Toxoplasmosis | Toxoplasma Gondii Profilin Family Protein;TGFB1;HSPA8;IL10RB;TRAF6;AKT1;LAMB3;IFNGR1;NFKBIA |
Staphylococcus aureus infection | HLA-DOA;FPR2;HLA-DMB;SELP;Hc;MBL2;C1R;C5AR1;PTAFR |
Tuberculosis | IFNA2;RFX5;CD209;TNF;HLA-DRB4;IL10RA;H2-AA;ITGAM;IFNA14 |
Influenza A | NFKBIB;IL12B;IFNGR1;STAT1;RSAD2;NLRP3;HNRNPUL1;TNFRSF10B;MAP2K7 |
HTLV-I infection | VCAM1;WNT10B;IL1R1;GSK3B;IKBKB;PPP3CC;ETS2;ETS1;VDAC3 |
Herpes simplex infection | Fasl;ARNTL;TLR2-1;SFRS9;PER2;EEF1D;C1QBP;DDX58;IFNAR2 |
Epstein-Barr virus infection | TAB2;HLA-DQA1;HSPB2;HLA-DRB4;POLR2H;RELA;CD44;PSMC1;PTMA |
Asthma | HLA-DQB1;CD40;HLA-DRA;IL9;HLA-DPA1;IL13;RNASE3;HLA-DPB1;H2-AA |
Autoi | CD40;H2-AB1;GZMB;IFNA14;IFNA5;IFNA1;TG;HLA-B;IFNA4 |
ne thyroid disease | IFNA8;HLA-DPA1;CD40LG;Fasl;IFNA6;CD80;Ifna15;HLA-DQB1;CD40 |
Inflammatory bowel disease (IBD) | TGFB3;Il23a; Il12b;IFNG;IL21R;NFKB1;HLA-DQA2;IL5;IFNGR2;IL12A |
Systemic lupus erythematosus | SNRPB;HIST1H2BN;HIST1H3C;HIST1H3D;HIST2H2BE;HLA-DQA1;HIST1H2BD;HLA-DOA;HIST1H4K |
Rheumatoid arthritis | CCL3L1;VEGFA;CXCL6;H2-AA;ICAM1;IL6;ATP6V0E2;TEK;ATP6V0A2 |
Allograft rejection | Fasl;HLA-DRB4;CD28;HLA-DRB3;H2-AA;TNF;IL5;IL12B;FASLG |
Graft-versus-host disease | HLA-DOA;HLA-A;H2-Q10;HLA-F;HLA-DMA;HLA-B;HLA-DQA2;FAS;CD86 |
Viral myocarditis | HLA-DMA;ABL1;HLA-DRB1;ACTB;H2-AA;FYN;HLA-DOA;RAC3;ACTG1 |
HLA-DQA2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA2 itself. We selected most functions HLA-DQA2 had, and list some proteins which have the same functions with HLA-DQA2. You can find most of the proteins on our site.
Function | Related Protein |
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MHC class II receptor activity | HLA-DQB2;HLA-DPA1;KRT17;HLA-DQA1;HLA-DRB3;HLA-DOA;HLA-DQA2;HLA-DQB1;HLA-DRA |
HLA-DQA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA2.
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