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HLA-DQA2

  • Official Full Name

    major histocompatibility complex, class II, DQ alpha 2

  • Overview

    This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
  • Synonyms

    HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2; HLA DXA; HLA class II histocompatibility antigen, DQ alpha 2 chain; HLA-DQA1; DX alpha chain; MHC class II DQA2; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DXA; DX-ALPH;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLA-DQA2-5494HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
Human HLA-DQA2-1279H Recombinant Human HLA-DQA2 Protein (24-214 aa), His-tagged E.coli His 24-214 aa
Homo sapiens (Human) RFL35265HF Recombinant Full Length Human Hla Class Ii Histocompatibility Antigen, Dq Alpha 2 Chain(Hla-Dqa2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-255)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLA-DQA2 Related Articles
  • HLA-DQA2 Related Research Area

HLA-DQA2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA2 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeRAB7B;HLA-DMB;ATP6V0B;DYNC1LI1;C3;CANX;CD14;THBS4A;SCARB1
Cell adhesion molecules (CAMs)MPZ;CLDN10A;PVRL2;NFASCA;PECAM1;CLDNK;NCAM1A;BLA;MADCAM1
Antigen processing and presentationHLA-DPA1;HLA-DQB1;HLA-F;NFYB;TAPBP;KLRC1;HLA-DRB1;HLA-A;HLA-DOB
Intestinal iHLA-DRB5;HLA-DQA2;CD40;HLA-DRA;CD28;Icosl;CXCR4B;BMA2;MHC2DAB
ne network for IgA productionTNFRSF17;IL15;HLA-DOB;IL4;HLA-DOA;HLA-DQA1;AICDA;MHC2DEB;H2-AB1
Type I diabetes mellitusFASLG;CD80;GAD2;PRF1;HLA-DRB4;GAD1;HLA-DMA;TNF;H2-Q10
LeishmaniasisCR1;ITGB2L;ITGB1;MAPK1;HLA-DRB1;MAP3K7;TAB2;FCGR1A;PTPN6
ToxoplasmosisToxoplasma Gondii Profilin Family Protein;TGFB1;HSPA8;IL10RB;TRAF6;AKT1;LAMB3;IFNGR1;NFKBIA
Staphylococcus aureus infectionHLA-DOA;FPR2;HLA-DMB;SELP;Hc;MBL2;C1R;C5AR1;PTAFR
TuberculosisIFNA2;RFX5;CD209;TNF;HLA-DRB4;IL10RA;H2-AA;ITGAM;IFNA14
Influenza ANFKBIB;IL12B;IFNGR1;STAT1;RSAD2;NLRP3;HNRNPUL1;TNFRSF10B;MAP2K7
HTLV-I infectionVCAM1;WNT10B;IL1R1;GSK3B;IKBKB;PPP3CC;ETS2;ETS1;VDAC3
Herpes simplex infectionFasl;ARNTL;TLR2-1;SFRS9;PER2;EEF1D;C1QBP;DDX58;IFNAR2
Epstein-Barr virus infectionTAB2;HLA-DQA1;HSPB2;HLA-DRB4;POLR2H;RELA;CD44;PSMC1;PTMA
AsthmaHLA-DQB1;CD40;HLA-DRA;IL9;HLA-DPA1;IL13;RNASE3;HLA-DPB1;H2-AA
AutoiCD40;H2-AB1;GZMB;IFNA14;IFNA5;IFNA1;TG;HLA-B;IFNA4
ne thyroid diseaseIFNA8;HLA-DPA1;CD40LG;Fasl;IFNA6;CD80;Ifna15;HLA-DQB1;CD40
Inflammatory bowel disease (IBD)TGFB3;Il23a; Il12b;IFNG;IL21R;NFKB1;HLA-DQA2;IL5;IFNGR2;IL12A
Systemic lupus erythematosusSNRPB;HIST1H2BN;HIST1H3C;HIST1H3D;HIST2H2BE;HLA-DQA1;HIST1H2BD;HLA-DOA;HIST1H4K
Rheumatoid arthritisCCL3L1;VEGFA;CXCL6;H2-AA;ICAM1;IL6;ATP6V0E2;TEK;ATP6V0A2
Allograft rejectionFasl;HLA-DRB4;CD28;HLA-DRB3;H2-AA;TNF;IL5;IL12B;FASLG
Graft-versus-host diseaseHLA-DOA;HLA-A;H2-Q10;HLA-F;HLA-DMA;HLA-B;HLA-DQA2;FAS;CD86
Viral myocarditisHLA-DMA;ABL1;HLA-DRB1;ACTB;H2-AA;FYN;HLA-DOA;RAC3;ACTG1

HLA-DQA2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA2 itself. We selected most functions HLA-DQA2 had, and list some proteins which have the same functions with HLA-DQA2. You can find most of the proteins on our site.

Function Related Protein
MHC class II receptor activityHLA-DQB2;HLA-DPA1;KRT17;HLA-DQA1;HLA-DRB3;HLA-DOA;HLA-DQA2;HLA-DQB1;HLA-DRA

HLA-DQA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA2.

Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).
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