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HLTF

  • Official Full Name

    helicase-like transcription factor

  • Overview

    This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    HLTF; helicase-like transcription factor; ZBU1; HLTF1; RNF80; HIP116; SNF2L3; HIP116A; SMARCA3; SNF2-like 3; RING finger protein 80; sucrose nonfermenting-like 3; sucrose nonfermenting protein 2-like 3; DNA-binding protein/plasminogen activator inhibitor 1 regulator; DNA-binding protein/plasminogen activator inhibitor-1 regulator; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HLTF-7859H Recombinant Human HLTF protein, His & T7-tagged E.coli His/T7 Ala837~Lys996 (Accession # Q14527)
Human HLTF-5489HCL Recombinant Human HLTF 293 Cell Lysate HEK293 N/A
Human HLTF-0512H Recombinant Human HLTF Protein (V58-A174), His tagged E.coli His V58-A174
Human HLTF-0511H Recombinant Human HLTF Protein (V58-A174), Tag Free E.coli No tag V58-A174
Human HLTF-3179H Recombinant Human HLTF Protein (Ala837-Lys996), N-His tagged E.coli N-His Ala837-Lys996
Mouse HLTF-7718M Recombinant Mouse HLTF Protein Mammalian Cell His
Mouse Hltf-7860M Recombinant Mouse Hltf protein, His & T7-tagged E.coli His/T7 Ala831~Lys990 (Accession # Q6PCN7)
Mouse HLTF-4231M Recombinant Mouse HLTF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HLTF-4231M-B Recombinant Mouse HLTF Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HLTF Related Articles

HLTF involved in several pathways and played different roles in them. We selected most pathways HLTF participated on our site, such as RB in Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLTF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RB in CancerRBP1;SMARCA2;DCK;TOP2A;RABIF;HMGB2;HLTF;ANLN;FAF1

HLTF has several biochemical functions, for example, ATP binding, ATPase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLTF itself. We selected most functions HLTF had, and list some proteins which have the same functions with HLTF. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDCK;MAP2K4;ORC5;ATP2B3B;GM711;GRK7A;DDX39AA;CHTF18;LANCL2
ATPase activityPSMC3;NSFA;KIF4A;DYNC2H1;ATP13A;KIF15;KIFC2;ABCA13;ABCF3
DNA bindingZNF573;MSL3;ARID1AA;H2BFWT;HMX3;ATF4B1;RARGB;SNAPC1;PPARG
RNA polymerase II core promoter proximal region sequence-specific DNA bindingPER1;TFAP4;RBPJB;POU4F2;POU2F3;SFPI1;NR6A1;ZNF92;DLX4
helicase activityFANCM;PL10;DDX39;SMARCAD1;HELQ;MCM8;DDX52;CHD8;CHD6
ligase activityRNF2;BIRC7;CCNB1IP1;ITCH;HACE1;XIAP;TRIM22;BRCA1;RTCB
poly(A) RNA bindingNUPL2;CANX;YTHDC2;FAM98B;MRPL11;PA2G4;EPPK1;FASTKD1;MCAT
protein bindingFAM127A;NUP133;SH2B2;PRKAR1A;MYOZ1;RARRES3;MR1;F10;YWHAH
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingFOXA1;PAX8;MEIS3;SP1;CEBPA;PPARA;ZFP292;YBX1;NOBOX
ubiquitin protein ligase activityRNF25;TRIM32;BTRC;PJA1;UBE2T;RFFL;MED7;RNF222;DZIP3
zinc ion bindingRNF150A;RARGB;RNF26;MORC4;MORC1;RNF144A;MMP14A;DPF2L;S100B

HLTF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLTF here. Most of them are supplied by our site. Hope this information will be useful for your research of HLTF.

b-box_pai1_3-5prime; S100A10; WBP4; CIAO1; USP7; BRF2; PHLDA3; SULT1C2; HSPA8; CDK9; UBE2Z; s10aa_chlae_protein; E2F3; PTBP3; S100a10

Helmer, RA; Dertien, JS; et al. Prolactin induces Jak2 phosphorylation of RUSHY195. MOLECULAR AND CELLULAR ENDOCRINOLOGY 338:79-83(2011).
Krijger, PHL; Lee, KY; et al. HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase. DNA REPAIR 10:438-444(2011).
  • Q&As
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