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HM13

Official Full Name

histocompatibility (minor) 13
Overview

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms

HM13; histocompatibility (minor) 13; minor histocompatibility antigen H13; dJ324O17.1; H13; IMP1; IMPAS; intramembrane protease; presenilin like protein 3; PSENL3; PSL3; signal peptide peptidase beta; signal peptide peptidase like 1; SPP; SPPL1; IMP-1; hI;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E. coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HM13-4855H	Recombinant Human HM13 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HM13-5486HCL	Recombinant Human HM13 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HM13-5487HCL	Recombinant Human HM13 293 Cell Lysate	HEK293	N/A		Inquiry
Human	HM13-21H	Recombinant Human HM13 protein, His-tagged	E. coli	His	111-220 aa	Inquiry
Human	HM13-3635HF	Recombinant Full Length Human HM13 Protein, GST-tagged	In Vitro Cell Free System	GST	143 amino acids	Inquiry
Rhesus Macaque	HM13-2104R	Recombinant Rhesus monkey HM13 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	HM13-1925R-B	Recombinant Rhesus Macaque HM13 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	HM13-1925R	Recombinant Rhesus Macaque HM13 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	HM13-11852Z	Recombinant Zebrafish HM13	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

HM13 involved in several pathways and played different roles in them. We selected most pathways HM13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HM13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

HM13 has several biochemical functions, for example, aspartic endopeptidase activity, intramembrane cleaving, peptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HM13 itself. We selected most functions HM13 had, and list some proteins which have the same functions with HM13. You can find most of the proteins on our site.

Function	Related Protein
aspartic endopeptidase activity, intramembrane cleaving	HM13;SPPL3;SPPL2B
peptidase activity	GM5136;ELA3L;CTS7;NOTS;HE1A;MMP1A;FAM108A1;CAPN5A;UFSP2
protein binding	TMEM27;TRAF2;COPS6;COA3;ACTA1;TMEM182;PARP4;KRT2;BCKDK
protein homodimerization activity	ANXA1;DARS2;MAP3K10;CISD2;PITX2;GSTM1;TIMM10;PTPRO;GAMT
ubiquitin protein ligase binding	TUBA1B;VCL;PARK2;ATP6V0C;AURKA;RNF40;YOD1;PRKAR1A;MDM2

HM13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HM13 here. Most of them are supplied by our site. Hope this information will be useful for your research of HM13.

LZTS2; XBP1; RNF139; DERL1; env; P4HB; ABHD16A; q9wmx2-pro_0000037541