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HMGA2

  • Official Full Name

    high mobility group AT-hook 2

  • Overview

    HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by chan
  • Synonyms

    HMGA2; high mobility group AT-hook 2; high mobility group (nonhistone chromosomal) protein isoform I C , HMGIC; high mobility group protein HMGI-C; BABL; LIPO; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • MYC
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HMGA2-4865H Recombinant Human HMGA2 Protein, GST-tagged Wheat Germ GST
Human HMGA2-592H Recombinant Human high mobility group AT-hook 2, His-tagged E.coli His
Human HMGA2-13840H Recombinant Human HMGA2, GST-tagged E.coli GST 1-108a.a.
Human HMGA2-5478HCL Recombinant Human HMGA2 293 Cell Lysate HEK293 N/A
Human HMGA2-178H Recombinant Human HMGA2 protein, His/GST-tagged E.coli His/GST 109
Human HMGA2-3199H Recombinant Human HMGA2 Protein (Met1-Asp109), N-His tagged E.coli N-His Met1-Asp109
Human HMGA2-3200H Recombinant Human HMGA2 Protein E.coli Tag Free
Mouse HMGA2-7727M Recombinant Mouse HMGA2 Protein Mammalian Cell His
Mouse HMGA2-4236M Recombinant Mouse HMGA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hmga2-179M Recombinant Mouse Hmga2 Protein, His/GST-tagged E.coli His/GST Met1~Asp108
Mouse Hmga2-1139M Recombinant Mouse Hmga2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HMGA2-4236M-B Recombinant Mouse HMGA2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HMGA2-11956Z Recombinant Zebrafish HMGA2 Mammalian Cell His
Chicken HMGA2-6559C Recombinant Chicken HMGA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HMGA2 Related Articles
  • HMGA2 Related Research Area

HMGA2 involved in several pathways and played different roles in them. We selected most pathways HMGA2 participated on our site, such as Transcriptional misregulation in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerSSX2;FEV;ARNT2;ITGAM;ELK4;TAF15;PPARG;FLT3;NTRK1
MicroRNAs in cancerMTOR;CD44;BMF;TTC6;BCL2L2;CCNE1;ZEB2;PLCG2;ERBB2

HMGA2 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity, AT DNA binding, C2H2 zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA2 itself. We selected most functions HMGA2 had, and list some proteins which have the same functions with HMGA2. You can find most of the proteins on our site.

Function Related Protein
5-deoxyribose-5-phosphate lyase activityHMGA2;HMGA1;XRCC6;HMGA1-RS1
AT DNA bindingCRIP1;HMGA1;HMGA2;MEF2C;POU3F4
C2H2 zinc finger domain bindingTHAP7;GATA2;LEF1;GATA1;TAF9;HMGA2;EHMT1;EHMT2;EBF1
DNA bindingTERFA;ZNF70;NFAT5A;MYC;INO80;ZNF625;IRF1;FOXC1B;ZNF571
DNA binding, bendingHHEX;FOXC1;FOXI1;TOP2B;FOXD1;GATA1;TOP2A;FOXD4;HMGB1
DNA-(apurinic or apyrimidinic site) lyase activityHMGA1B;HMGA1A;APEX2;APLF;HMGA2;ALKBH1;RPS3;HMGA1-RS1;NEIL3
DNA-dependent protein kinase activityALPK2;XRCC6BP1;ATM;PRKDC;HMGA2
MH1 domain binding
MH2 domain binding
SMAD bindingFLNA;CTNNB1;MEF2A;DAB2;SNW1;FOXH1;RNF111;EP300;TGFBR2
cAMP response element bindingCREB3L1;CREB3L2;CREB3L3L;CREB3;CREB3L3;CREB3L4;ATF6;E4F1;JUN
core promoter bindingHDAC4;E2F7;HNRNPU;SFPI1;HDAC2;MTA1;E2F3;IFI203;PYDC3
nucleosomal DNA bindingH2AFY;H3F3B;HMGN1;HMGN5;HMGA2;HMGN3;H3F3A;NSBP1;RCC1
protein bindingMYBPC2;AKIP1;SRSF5;ZNF286A;SCARF1;FOXC1;TESC;SEPT10;RMI1
regulatory region DNA bindingNFKB1;IRF3;IRF6;IRF8;IRF5;HMGA2;IRF4A;IRF1B;IRF1A
contributes_to transcription factor activity, transcription factor binding
transcription factor bindingHDAC3;TRIM11;STK4;ATF7;E2F5;CDK9;NFYC;RB1;HDAC11
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSOX2;IRF4;ATF2;KLF15;MTF1;NCOA3;KLF4;ETV1;POU1F1
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingNKX6-2;POU4F2;GFI1;HOXA2;HES1;SPI1;MLXIPL;SALL1;ZFP536

HMGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA2.

PRMT6; PRMT1; ssdna_dadts; H2AFX; ATM

Rudzinski, ER; Anderson, JR; et al. Myogenin, AP2 beta, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:654-659(2014).
Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).
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