hmga2
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  • Official Full Name
  • high mobility group AT-hook 2
  • Background
  • HMGA2 belongs to the family of high mobility group with AT-hook DNA binding domain. HMGA proteins are considered architectural transcription factors; they do not have direct transcriptional activation capacity, but instead regulate gene expression by chan
  • Synonyms
  • HMGA2; high mobility group AT-hook 2; high mobility group (nonhistone chromosomal) protein isoform I C , HMGIC; high mobility group protein HMGI-C; BABL; LIPO; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group
Cat.#:HMGA2-178HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA2 Protein, His/GST-tagged
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Cat.#:HMGA2-4865HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HMGA2 Protein, GST-tagged
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Cat.#:Hmga2-179MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hmga2 Protein, His/GST-tagged
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Cat.#:HMGA2-13840HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HMGA2, GST-tagged
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Cat.#:HMGA2-592HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human high mobility group AT-hook 2, His-tagged
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Cat.#:HMGA2-7727MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HMGA2 Protein
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Cat.#:HMGA2-6559CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HMGA2
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Cat.#:HMGA2-11956ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HMGA2
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Cat.#:HMGA2-5478HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HMGA2 293 Cell Lysate
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Involved Pathway

HMGA2 involved in several pathways and played different roles in them. We selected most pathways HMGA2 participated on our site, such as Transcriptional misregulation in cancer, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
CD86; LRP2BP; ETV7; TLX1; JMJD1C; GZMB; Bcl2a1b; SIX4; BCL6; FEV
MicroRNAs in cancer
SIRT1; ABCB1A; FOXP1; PTGS2; PIK3R2; RECK; RAF1; Abcb1b; TGFB2; DICER1

Protein Function

HMGA2 has several biochemical functions, for example, 5-deoxyribose-5-phosphate lyase activity, AT DNA binding, C2H2 zinc finger domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGA2 itself. We selected most functions HMGA2 had, and list some proteins which have the same functions with HMGA2. You can find most of the proteins on our site.
Function
Related Protein
Function 5-deoxyribose-5-phosphate lyase activity
Related Protein HMGA2; HMGA1-RS1; XRCC6; HMGA1
Function AT DNA binding
Related Protein CRIP1; HMGA2; HMGA1; POU3F4; MEF2C
Function C2H2 zinc finger domain binding
Related Protein EHMT1; THAP7; EHMT2; GATA2; EBF1; HMGA2; WT1; U2AF2; LEF1; TAF9
Function DNA binding
Related Protein ZBTB41; HNF4A; TA; HOXA11B; RAD51L3; RXRBA; NKX6.3; C17orf49; MYCB; ALX4
Function DNA binding, bending
Related Protein FOXC1; FOXL1; GATA1; TOP2B; HMGB3; LEF1; FOXD1; TERF1; HMGB2; FOXD4
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein HMGA1A; APLF; HMGA2; NEIL2; NEIL3; RPS3; HMGA1B; ALKBH1; APEX1; APEX2
Function DNA-dependent protein kinase activity
Related Protein ALPK2; PRKDC; ATM; HMGA2; XRCC6BP1
Function MH1 domain binding
Related Protein HMGA2
Function MH2 domain binding
Related Protein HMGA2
Function SMAD binding
Related Protein CREBBP; SKOR2; USP15; TOB1; SKIA; ACVR1; STUB1; ACVRL1; SKOR1B; TCF12
Function cAMP response element binding
Related Protein CREB3L4; CREB3L2; ATF6; CREB3L3L; ATF6B; CREB3L1; CREB3L3A; CREB1; JUN; CREB3
Function core promoter binding
Related Protein HNRNPU; INSM1B; EZH2; NKX3; E2F3; IRF9; MYOG; NEUROG3; E2F2; MTA1
Function nucleosomal DNA binding
Related Protein HMGN3; HMGN5; HMGN2; H3F3B; HMGN1; H3F3C; HMGA2; H3F3A; HNRNPC; H2AFZ
Function protein binding
Related Protein TOP2A; FLI1; PPP1R37; CTIF; PYGL; SIK3; FUT11; SEC31A; SULT1A3; IFIT3
Function regulatory region DNA binding
Related Protein IRF5; IRF8; IRF6; IRF1B; NFKB1; IRF1A; IRF2A; IRF3; HMGA2; IRF4A
Function contributes_to transcription factor activity, transcription factor binding
Related Protein HMGA2
Function transcription factor binding
Related Protein TLE1; E2F5; STK4; TRERF1; PPP1R13BA; MDFI; LCOR; KAT8; CSNK2B; ZBTB49
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CTCFL; EBF1; HOXA10; TFAP4; CRX; POU4F2; MYB; ZSCAN21; RELA; PAX8
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein TCF21; NFE2L3; HOXA2; MXD1; FOXO1; ATF3; NKX6-2; YY1; TBX15; NKX6

Interacting Protein

HMGA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGA2.
PRMT6; PRMT1; ssdna_dadts; H2AFX; ATM

HMGA2 Related Articles

Rudzinski, ER; Anderson, JR; et al. Myogenin, AP2 beta, NOS-1, and HMGA2 Are Surrogate Markers of Fusion Status in Rhabdomyosarcoma A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:654-659(2014).
Chieffi, P; Chieffi, S; et al. Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumors: An overview. JOURNAL OF CELLULAR PHYSIOLOGY 228:1641-1646(2013).