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HMGB1

  • Official Full Name

    high mobility group box 1

  • Overview

    HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1,Identified as a membrane associated protein termed “amphoterin,” mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice.
  • Synonyms

    HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydrate binding protein; HMG-1; high-mobility group box 1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; SBP-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Calf
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Calf Thymus
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Hi-5 Inscet Cell
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|Fc
  • Mouse|IgG2a|Fc
  • MYC
  • N/A
  • N
  • hFc
  • SUMO
  • MARI
  • No tag
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HMGB1-451H Active Recombinant Human High-Mobility Group Box 1, MIgG2a Fc-tagged CHO Fc
Human HMGB1-1048H Active Recombinant Human High-Mobility Group Box 1 E.coli N/A
Human HMGB1-8460H Active Recombinant Human HMGB1, His-tagged E.coli His
Human HMGB1-452H Active Recombinant Human High-Mobility Group Box 1, HIgG1 Fc-tagged CHO Fc
Human HMGB1-559H Recombinant Human HMGB1 protein, His-tagged E.coli His Pro9~Arg163
Human HMGB1-752H Active Recombinant Human HMGB1 protein(Met1-Glu215), hFc-tagged HEK293 N-hFc Met1-Glu215
Human HMGB1-29332TH Recombinant Human HMGB1, His-tagged E.coli His
Human HMGB1-29334TH Recombinant Human HMGB1 N/A
Human HMGB1-13841H Recombinant Human HMGB1, His-tagged E.coli His 1-215a.a.
Human HMGB1-3827H Active Recombinant Human HMGB1 protein, His-tagged HEK293 His Met1-Glu215
Human HMGB1-255H Recombinant Human HMGB1, StrepII-tagged Human Cell Strep II 2-215, 214 a.a.
Human HMGB1-526H Active Recombinant Human HMGB1 Protein, His-tagged E. coli His
Human HMGB1-454H Recombinant Human HMGB1 protein, His & Fc-tagged HEK293F His/Fc Met1~Glu215
Human HMGB1-532H Recombinant Human High-mobility Group Box 1, His-tagged Hi-5 Inscet Cell His
Human HMGB1-4866H Recombinant Human HMGB1 Protein, GST-tagged Wheat Germ GST
Human HMGB1-1984H Recombinant Human High-mobility Group Box 1, His-tagged Sf9 Insect Cell His
Human HMGB1-2076HCL Recombinant Human HMGB1 cell lysate Human Cell N/A
Human HMGB1-26H Recombinant Human HMGB1 protein E.coli N/A 223
Human HMGB1-3079H Recombinant Human HMGB1 Protein (Gly2-Phe89) E.coli Tag Free Gly2-Phe89
Human HMGB1-363H Recombinant Human HMGB1 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 214
Human HMGB1-017H Recombinant Human HMGB1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human HMGB1-5169H Recombinant Human HMGB1 protein, GST-tagged E.coli GST 8-179aa
Human HMGB1-3080H Recombinant Human HMGB1 Protein (Met1-Glu215), N-His tagged E.coli N-His Met1-Glu215
Human HMGB1-2246H Recombinant Human HMGB1 Protein, His-tagged E.coli N-His Gly2-Arg97
Human HMGB1-964H Recombinant Human HMGB1 Protein, His-tagged HEK293F N-His Met1-Glu215
Human HMGB1-965H Recombinant Human HMGB1 Protein, His-tagged HEK293F N-His Lys88-Tyr162
Human HMGB1-146H Active Recombinant Human HMGB1 Protein (Met1-Asp169), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 N-His-SUMO Met1-Asp169
Human Hmgb1-5427H Recombinant Human Hmgb1 protein, His-tagged Yeast His 2-215aa
Human HMGB1-0715H Recombinant Human HMGB1 Protein (M1-E215), Tag Free E.coli No tag M1-E215
Human HMGB1-1079H Recombinant Human HMGB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HMGB1-2564H Active Recombinant Human HMGB1 protein, His-tagged HEK293 His Met1-Glu215
Human HMGB1-116H Recombinant Active Human HMGB1 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human HMGB1-3643HF Recombinant Full Length Human HMGB1 Protein, GST-tagged In Vitro Cell Free System GST 215 amino acids
Human HMGB1-0716H Recombinant Human HMGB1 Protein (M1-E215), His tagged E.coli His M1-E215
Human HMGB1-700HFL Recombinant Full Length Human HMGB1 Protein, C-Flag-tagged Mammalian cells Flag
Human HMGB1-291H Recombinant Human HMGB1 Protein, His-tagged HEK293 His 215
Human HMGB1-3078H Recombinant Human HMGB1 Protein (Pro92-Val176), N-MARI tagged E.coli N-MARI Pro92-Val176
Human HMGB1-1079H-B Recombinant Human HMGB1 Protein Pre-coupled Magnetic Beads HEK293
Human HMGB1-143H Active Recombinant Human HMGB1 Protein (Met1-Asp169, C23A, C45A), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 N-His-SUMO Met1-Asp169
Human HMGB1-3077H Recombinant Human HMGB1 Protein (Met1-Glu215), N-His tagged Mammalian cells N-His Met1-Glu215
Human HMGB1-145H Active Recombinant Human HMGB1 Protein (Met1-Glu215), C-His tagged, Animal-free, Carrier-free E.coli C-His Met1-Glu215
Human HMGB1-144H Active Recombinant Human HMGB1 Protein (Met1-Asp169, C23A, C45A, C106A), N-His-SUMO tagged, Animal-free, Carrier-free HEK293 N-His-SUMO Met1-Asp169
Mouse Hmgb1-2628M Active Recombinant Mouse Hmgb1 protein, His-tagged E.coli His
Mouse Hmgb1-01M Active Recombinant Mouse Hmgb1 Protein, His-Tagged E.coli His
Mouse Hmgb1-6948M Active Recombinant Mouse Hmgb1 protein(Met1-Glu215), hFc-tagged HEK293 N-hFc Met1-Glu215
Mouse HMGB1-1677MCL Recombinant Mouse HMGB1 cell lysate Human Cell N/A
Mouse Hmgb1-4051M Recombinant Mouse Hmgb1 Protein (Met1-Glu215), N-His tagged Mammalian cells N-His Met1-Glu215
Mouse Hmgb1-1134M Recombinant Mouse Hmgb1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Hmgb1-6947M Recombinant Mouse Hmgb1 protein, His-tagged HEK293 His Met1-Glu215
Mouse Hmgb1-4308M Recombinant Mouse Hmgb1 protein, His-tagged E.coli His 2-215aa
Mouse Hmgb1-966M Recombinant Mouse Hmgb1 Protein, His-tagged HEK293F N-His Met1-Glu215
Mouse Hmgb1-37M Active Recombinant Mouse Hmgb1 Protein (Met1-Asp169), C-His tagged, Animal-free, Carrier-free E.coli C-His Met1-Asp169
Mouse Hmgb1-1625M Recombinant Mouse Hmgb1 Protein, His-tagged E.coli N-His Pro9-Arg163
Rat HMGB1-001R Active Recombinant Rat HMGB1, HIgG1 Fc-tagged CHO Fc
Rat Hmgb1-18R Active Recombinant Rat Hmgb1 protein E.coli N/A
Rat Hmgb1-19R Active Recombinant Rat Hmgb1 protein, LPS-Free E.coli N/A HMGB1 consists of 215 amino acid residues.
Rat Hmgb1-292R Recombinant Rat Hmgb1, His-tagged E.coli His
Rat Hmgb1-593R Recombinant Rat Hmgb1 Protein, His-tagged E.coli His Met1~Glu215
Rat Hmgb1-293R Recombinant Rat Hmgb1, Fc-tagged CHO Fc
Rat Hmgb1-5428R Recombinant Rat Hmgb1 protein, His-tagged Yeast His 2-215aa
Rat Hmgb1-3037R Recombinant Rat Hmgb1 protein, His-tagged E.coli His 2-215aa
Rat Hmgb1-1241R Recombinant Rat Hmgb1 protein, His&Myc-tagged Yeast His&Myc 2-215aa
Calf HMGB1-8447B Active Native Bovine HMGB1 Calf Thymus N/A
Cynomolgus Monkey HMGB1-589C Recombinant Cynomolgus HMGB1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey HMGB1-335C Recombinant Cynomolgus Monkey HMGB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey HMGB1-335C-B Recombinant Cynomolgus Monkey HMGB1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HMGB1-2108R Recombinant Rhesus monkey HMGB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HMGB1-1929R-B Recombinant Rhesus Macaque HMGB1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HMGB1-1929R Recombinant Rhesus Macaque HMGB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken HMGB1-6464C Recombinant Chicken HMGB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HMGB1 Related Articles
  • HMGB1 Related Research Area

HMGB1 involved in several pathways and played different roles in them. We selected most pathways HMGB1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with HMGB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Base excision repairUNG;MUTYH;APEX2;LIG3;MBD4;NEIL2;POLD3;POLB;PNKP

HMGB1 has several biochemical functions, for example, C-X-C chemokine binding, DNA binding, bending, DNA polymerase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HMGB1 itself. We selected most functions HMGB1 had, and list some proteins which have the same functions with HMGB1. You can find most of the proteins on our site.

Function Related Protein
C-X-C chemokine bindingCXCR3;CXCR7;HMGB1;CXCR6
DNA binding, bendingTOP2A;HMGB1;TOP2B;HMGB3;TFAM;HHEX;FOXD1;GATA1;FOXD4
DNA polymerase bindingHMGB1;CDK2AP1;RAD51;LONP1;FANCD2;ACD;FANCI;PCNA;SMARCA4
RAGE receptor bindingS100A7;S100A9;FPR1;S100P;HMGB1;S100B;HMGB2;S100A4;S100A12
bubble DNA bindingNEIL3;RECQL4;HMGB1;BLM;ERCC5;WRN
chemoattractant activityHMGB2;VEGFA;VHL;SAA4;PDGFB;SAA3;CCL5;SCG2;VEGFB
chromatin bindingTMPOA;SSBP1;SOX9;UXT;SKOR2;JMJD5;MEIS3;TFAP2A;EZH1
cytokine activityBMP7A;Ifna15;LFT2;IFNA21;BMP3;CMTM7;TGFB2;INHBE;GDF3
damaged DNA bindingRPA3;XRCC6;ERCC4;REV1;CREBBP;RAD52;DCLRE1C;TP73;XPA
double-stranded DNA bindingHMGB1;SP1;IFI16;SETMAR;TP53;NKX2-8;RAD51C;RAD51L3;USF1
double-stranded RNA bindingMTDH;HSP90AB1;OASL2;TLR8;HSPD1;DHX15;SUPV3L1;LRRFIP1;LSM14A
four-way junction DNA bindingHMGB1;RAD51L1;YY1;HMGB2;RAD51;DMC1;HMGB3;RAD51L3;MEN1
lipopolysaccharide bindingBPIFC;TRIL;KIAA0644;CD6;SCARB1;LBP;TLR2;TLR4;TREM2
lyase activityETNPPL;ALDOAA;Car2;ENO1A;GLDC;PTPLA;GC2;TSEN34;CAR13
poly(A) RNA bindingBTF3;HNRNPA0;RRP1;CLNS1A;PNPT1;PTCD2;DUSP11;MBNL3;MYBBP1A
protein bindingC11orf49;CUL1;HBA1;GEMIN7;CDH23;HNRNPF;PFDN4;METTL13;HSPBP1
repressing transcription factor bindingRELA;DDX20;MAGEA2B;HDAC4;NOC2L;CBX5;PRDM5;ARNTL;TLE4
single-stranded DNA bindingLUZP4;DMC1;NUP35;RAD51D;RAD23B;DDX11;PURA;RPA2;HNRNPK
single-stranded RNA bindingIFIH1;CBX7;AGO1;POLR2G;DLX2;DHX58;ENDOV;HNRNPA1;SNRPC
supercoiled DNA bindingHMGB2;PSIP1;HMGB1;RPS3
transcription factor activity, sequence-specific DNA bindingMNX2A;SOX3;PBX1;CEBPA;E2F7;POU5F3;TBX18;SP1;NR5A5
transcription factor bindingARRB1;GTF2B;CHCHD2;GPX3;UBN1;DNAJA3;E2F1;PRICKLE1;NEUROD1

HMGB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HMGB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HMGB1.

HTT; AGTRAP; MSH2; CSNK1A1

Roudier, M; Li, XD; et al. Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury. ARTHRITIS AND RHEUMATISM 65:721-731(2013).
Takaishi, H; Kanai, T; et al. Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype. JOURNAL OF GASTROENTEROLOGY 47:969-977(2012).
  • Q&As
  • Reviews

Q&As (6)

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Why is HMGB1 protein associated with tumors? 11/07/2019

This protein can promote tumor growth, invasion and angiogenesis, and plays an important role in tumor immune evasion.

Is HMGB1 protein involved in tumor metastasis? 11/05/2019

Yes, HMGB1 protein plays an important role in tumor metastasis, particularly by promoting invasion of tumor cells and migration of the hematopoietic system.

What is the association between HMGB1 protein and cardiovascular disease? 10/02/2019

Is involved in inflammatory response, vascular damage, and thrombosis in cardiovascular disease and may be associated with myocardial ischemia-reperfusion injury.

What is the effect of HMGB1 protein on the immune system? 08/31/2019

HMGB1 protein can promote the activation, chemotaxis and inflammatory response of immune cells, and is also involved in regulating the balance of autoimmune response.

What role does HMGB1 play in diabetes? 08/21/2019

HMGB1 protein is associated with processes such as chronic inflammation and insulin resistance in diabetes and may be a potential target for treatment and prevention.

Does HMGB1 play a role in liver disease? 08/15/2019

The protein is involved in pathological processes such as liver fibrosis, hepatitis, and liver cancer in liver disease and may be a target for therapeutic strategies.

Customer Reviews (3)

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Reviews
09/22/2021

    Broad storage conditions of HMGB1ins make the experimental process more stable and reliable, which provides a strong guarantee for scientific research.

    05/02/2020

      I found that tHMGB1 exhibited very good stability during storage, which allowed us to perform experiments easily and obtain reliable results.

      01/11/2019

        The anti-contamination ability of HMGB1 was excellent in Western blot, and the contamination problem in the experiment was avoided.

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