HNMT
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Official Full Name
histamine N-methyltransferase
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Overview
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. -
Synonyms
HNMT; histamine N-methyltransferase; HMT; HNMT-S1; HNMT-S2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Rat Kidney
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- HNMT Related Research Area
HNMT involved in several pathways and played different roles in them. We selected most pathways HNMT participated on our site, such as Histidine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Histidine metabolism | CARNS1;ALDH3A2A;ALDH2.1;AOC1;MAOB;AMDHD1;FTCD;ASPA;MAOA |
HNMT has several biochemical functions, for example, histamine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNMT itself. We selected most functions HNMT had, and list some proteins which have the same functions with HNMT. You can find most of the proteins on our site.
Function | Related Protein |
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histamine N-methyltransferase activity |
HNMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNMT here. Most of them are supplied by our site. Hope this information will be useful for your research of HNMT.
TERF1; CAMK2D; TINF2; POT1; Tpm1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, HNMT dysfunction has been associated with gastrointestinal disorders, and understanding its role may open avenues for novel therapeutic strategies.
HNMT is involved in the inactivation of histamine in the central nervous system, influencing neurotransmission and potentially impacting conditions like schizophrenia and anxiety disorders.
Research is underway to investigate whether HNMT levels or activity could serve as predictive markers for treatment response in conditions where histamine regulation is implicated.
HNMT is involved in the metabolism of certain drugs, and variations in its activity can influence drug responses and potential interactions.
Some studies suggest that HNMT may play a role in certain cancers, making it a potential target for therapeutic interventions. However, more research is needed in this area.
Customer Reviews (3)
Write a reviewHNMT protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.
Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.
Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the HNMT protein.
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