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HOMER3

  • Official Full Name

    homer homolog 3 (Drosophila)

  • Overview

    This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
  • Synonyms

    HOMER3; homer homolog 3 (Drosophila); homer protein homolog 3; HOMER 3; HOME3_HUMAN; Homer 3D protein; Homer neuronal immediate early gene 3; Homer-3; VESL3; Homer, neuronal immediate early gene, 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HOMER3-67H Recombinant Human Homer Homolog 3 (Drosophila), His-tagged E.coli His
Human HOMER3-13881H Recombinant Human HOMER3, His-tagged E.coli His 1-361a.a.
Human HOMER3-4926H Recombinant Human HOMER3 Protein, GST-tagged Wheat Germ GST
Human HOMER3-5436HCL Recombinant Human HOMER3 293 Cell Lysate HEK293 N/A
Human HOMER3-1115H Recombinant Human HOMER3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HOMER3-2568H Recombinant Human HOMER3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HOMER3-3692HF Recombinant Full Length Human HOMER3 Protein, GST-tagged In Vitro Cell Free System GST 361 amino acids
Human HOMER3-247H Recombinant Human HOMER3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse HOMER3-7777M Recombinant Mouse HOMER3 Protein Mammalian Cell His
Mouse HOMER3-4270M Recombinant Mouse HOMER3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Homer3-3427M Recombinant Mouse Homer3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HOMER3-4270M-B Recombinant Mouse HOMER3 Protein Pre-coupled Magnetic Beads HEK293
Rat HOMER3-2889R Recombinant Rat HOMER3 Protein Mammalian Cell His
Rat HOMER3-2544R-B Recombinant Rat HOMER3 Protein Pre-coupled Magnetic Beads HEK293
Rat HOMER3-2544R Recombinant Rat HOMER3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HOMER3-2130R Recombinant Rhesus monkey HOMER3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HOMER3-1951R-B Recombinant Rhesus Macaque HOMER3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque HOMER3-1951R Recombinant Rhesus Macaque HOMER3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HOMER3-11335Z Recombinant Zebrafish HOMER3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HOMER3 Related Articles

HOMER3 involved in several pathways and played different roles in them. We selected most pathways HOMER3 participated on our site, such as FoxO signaling pathway, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOMER3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayGABARAP;PRKAG2;SGK2;MAPK8A;NRAS;HOMER2;HOMER3;KLF2;PRKAG3B
Glutamatergic synapsePRKCB;GRM7;GRIK5;PPP3CA;PRKCA;GNG5;HOMER3;GRIN2A;GRM4

HOMER3 has several biochemical functions, for example, G-protein coupled glutamate receptor binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOMER3 itself. We selected most functions HOMER3 had, and list some proteins which have the same functions with HOMER3. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled glutamate receptor bindingHOMER1;HOMER1B;HOMER3;HOMER2
protein C-terminus bindingSHANK3;KSR1;ERCC2;SNX17;XRCC5;ERCC1;HIC2;AGO2;FBLN1
protein bindingIL12B;MPZL1L;SGCA;ASF1B;MLANA;MITF;MAP3K9;KBTBD7;SERPINA3K
protein domain specific bindingRAP2B;NFASC;SHROOM2;PLAUR;TFDP2;VRK2;NDE1;OCLN;YWHAQ

HOMER3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOMER3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOMER3.

FAT1; Snw1; APP; ABI3; q9wmx2-pro_0000037548; SRPK2; Cdc16; FRYL; MOS; ul34_ebvb9; gp350_ebvb9; GN

Mizutani, A; Kuroda, Y; et al. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. JOURNAL OF NEUROSCIENCE 28:5369-5382(2008).
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