hoxa10
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  • Official Full Name
  • homeobox A10
  • Background
  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
  • Synonyms
  • HOXA10; homeobox A10; PL; HOX1; HOX1H; HOX1.8; homeobox protein Hox-A10; homeo box A10; homeobox protein 1H; homeobox protein HOXA10; homeobox protein Hox-1H; homeobox protein Hox-1.8;
Cat.#:HOXA10-4939HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HOXA10 Protein, GST-tagged
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Cat.#:HOXA10-7785MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HOXA10 Protein
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Cat.#:HOXA10-5429HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HOXA10 293 Cell Lysate
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Involved Pathway

HOXA10 involved in several pathways and played different roles in them. We selected most pathways HOXA10 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXA10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer
HIST3H3; RUNX1; HPGD; WHSC1; NUPR1; BMI1; HDAC2; MLL1; PER2; TLX1

Protein Function

HOXA10 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, histone deacetylase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXA10 itself. We selected most functions HOXA10 had, and list some proteins which have the same functions with HOXA10. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SMAD2; MSX2; TFAM; T; SMAD4; SREBF2; MAX; H2AFZ; NKX3-2; ETV6
Function histone deacetylase binding
Related Protein GCM1; NKX3-1; HEY2; RAD9; HDAC4; BCOR; BRMS1LA; RUNX2; DNMT3B; HES1
Function protein binding
Related Protein VASP; RAET1D; RTN3; HNRNPUL1; SSTR3; TYRP1; KDM2B; TRAPPC6A; AKT1; KRT18
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein PAX5; BCL11B; ATOH1; PITX3; EGR1; NFKB2; TCF12; CTCFL; TP53; IRF4

Interacting Protein

HOXA10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXA10 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXA10.
SPI1; MYC; PTPN11

HOXA10 Related Articles

Kallen, AN; Haines, K; et al. HOXA10 Regulates Expression of Cytokeratin 15 in Endometrial Epithelial Cytoskeletal Remodeling. REPRODUCTIVE SCIENCES 21:892-897(2014).
Cui, XP; Qin, CK; et al. HOXA10 Promotes Cell Invasion and MMP-3 Expression Via TGF beta 2-Mediated Activation of the p38 MAPK Pathway in Pancreatic Cancer Cells. DIGESTIVE DISEASES AND SCIENCES 59:1442-1451(2014).