hps4
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  • Official Full Name
  • Hermansky-Pudlak syndrome 4
  • Background
  • Hermansky-Pudlak syndrome is a disorder of organelle biogenesis in which oculocutaneous albinism, bleeding, and pulmonary fibrosis result from defects of melanosomes, platelet dense granules, and lysosomes. Mutations in this gene as well as several others can cause this syndrome. The protein encoded by this gene appears to be important in organelle biogenesis and is similar to the mouse light ear protein. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • HPS4; Hermansky-Pudlak syndrome 4; Hermansky-Pudlak syndrome 4 protein; KIAA1667; LE; Hermansky Pudlak syndrome 4 protein; Light ear protein homolog; light-ear protein homolog; bK1048E9.4; bK1048E9.5
Cat.#:HPS4-13927HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HPS4, His-tagged
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Cat.#:Hps4-1858MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hps4 protein, His & T7-tagged
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Cat.#:HPS4-10653ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HPS4
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Cat.#:HPS4-5395HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HPS4 293 Cell Lysate
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Protein Function

HPS4 has several biochemical functions, for example, protein binding, protein dimerization activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HPS4 itself. We selected most functions HPS4 had, and list some proteins which have the same functions with HPS4. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein TRAP1; BRD8; MED8; FAM206A; EDC3; COMMD10; GDF5; EXOC4; MRC2; SOX10
Function protein dimerization activity
Related Protein STK4; PPP3CB; TFEC; MESP1; NHLH1; POLR2J2; ARNTL2; BTRC; HIF1AB; HER2
Function protein homodimerization activity
Related Protein TOX3; CDA; BAK1; RAB11FIP3; NADK2; RENBP; PRPS1; IDE; PRKG2; CEACAM5

Interacting Protein

HPS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HPS4.
HPS1; RAC1

HPS4 Related Articles

Nazarian, R; Huizing, M; et al. An immunoblotting assay to facilitate the molecular diagnosis of Hermansky-Pudlak syndrome. MOLECULAR GENETICS AND METABOLISM 93:134-144(2008).
Starcevic, M; Dell'Angelica, EC; et al. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). JOURNAL OF BIOLOGICAL CHEMISTRY 279:28393-28401(2004).