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HTR1B

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

  • Overview

    The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]
  • Synonyms

    HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB; 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cavia porcellus (Guinea pig)
  • Chicken
  • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
  • Equus caballus (Horse)
  • Felis catus (Cat) (Felis silvestris catus)
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Oryctolagus cuniculus (Rabbit)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • Spalax ehrenbergi (Middle East blind mole rat) (Nannospalax ehrenbergi)
  • Vulpes vulpes (Red fox)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • In vitro E. coli expression system
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Flag,His
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR1B-14002H Recombinant Human HTR1B, His-tagged E.coli His 228-315a.a.
Human HTR1B-5337HCL Recombinant Human HTR1B 293 Cell Lysate HEK293 N/A
Human HTR1B-5251H Recombinant Human HTR1B Protein, GST-tagged Wheat Germ GST
Human HTR1B-1086HFL Recombinant Human HTR1B protein, His&Flag-tagged HEK293 His&Flag 1-390 aa
Human HTR1B-0284H Recombinant Human HTR1B Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-390aa
Human HTR1B-392H Recombinant Human HTR1B Full Length Transmembrane protein, His-SUMO-tagged In vitro E. coli expression system His-SUMO 1-390aa
Human HTR1B-0500H Recombinant Human HTR1B Protein (N32-I239, L138W, A306-S390 end), Flag, His tagged Insect Cell Flag,His N32-I239, L138W, A306-S390 end
Mouse HTR1B-7929M Recombinant Mouse HTR1B Protein Mammalian Cell His
Mouse HTR1B-4372M-B Recombinant Mouse HTR1B Protein Pre-coupled Magnetic Beads HEK293
Mouse HTR1B-4372M Recombinant Mouse HTR1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HTR1B-2960R Recombinant Rat HTR1B Protein Mammalian Cell His
Rat HTR1B-2615R Recombinant Rat HTR1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HTR1B-2615R-B Recombinant Rat HTR1B Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL5380CF Recombinant Full Length Dog 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-389)
Cavia porcellus (Guinea pig) RFL17414CF Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-389)
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL36133CF Recombinant Full Length Cricetulus Griseus 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-386)
Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) RFL19861DF Recombinant Full Length Didelphis Marsupialis Virginiana 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-388)
Equus caballus (Horse) RFL6214EF Recombinant Full Length Horse 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-390)
Felis catus (Cat) (Felis silvestris catus) RFL24771FF Recombinant Full Length Cat 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-389)
Gorilla gorilla gorilla (Western lowland gorilla) RFL2619GF Recombinant Full Length Gorilla Gorilla Gorilla 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-390)
Homo sapiens (Human) RFL18079HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-390aa)
Mus musculus (Mouse) RFL22447MF Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-386)
Oryctolagus cuniculus (Rabbit) RFL25361OF Recombinant Full Length Rabbit 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-390)
Pan troglodytes (Chimpanzee) RFL856PF Recombinant Full Length Pan Troglodytes 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-390)
Rattus norvegicus (Rat) RFL32732RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-386)
Spalax ehrenbergi (Middle East blind mole rat) (Nannospalax ehrenbergi) RFL10501SF Recombinant Full Length Spalax Ehrenbergi 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-386)
Vulpes vulpes (Red fox) RFL4328VF Recombinant Full Length Vulpes Vulpes 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged E.coli expression system His Full Length (1-389)
Zebrafish HTR1B-6992Z Recombinant Zebrafish HTR1B Mammalian Cell His
Chicken HTR1B-4068C Recombinant Chicken HTR1B Mammalian Cell His
Kit-0996 DL-Serine Assay Kit (Fluorometric) N/A
Kit-1350 HTR1B U2OS β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HTR1B Related Research Area

HTR1B involved in several pathways and played different roles in them. We selected most pathways HTR1B participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayGLI1;FFAR2;AKT1;ARAP3;GABBR1;NFKB1;NPY1R;HTR1A;GRIA1
Neuroactive ligand-receptor interactionS1PR3;PRP2;TAAR13D;PTAFR;TACR1A;GRM3;CSH1;CHRNB4;GRIK4
Serotonergic synapseCYP2C50;PLA2G4A;PRKACB;GNG3;HTR3A;HTR2C;KCND2;GNAI2;HTR1B

HTR1B has several biochemical functions, for example, drug binding, protein binding, serotonin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR1B itself. We selected most functions HTR1B had, and list some proteins which have the same functions with HTR1B. You can find most of the proteins on our site.

Function Related Protein
drug bindingPDXK;CYP2D6;CNR1;DAAM2;SRP54B;CYP4B1;CHRM2;DRD3;CYP2C9
protein bindingZFYVE19;MSH2;C14orf104;GIMAP7;IFI6;HSP90AA1.1;RPA2;KPNB1;TNKS2
serotonin bindingHTR2C;HTR1B;HTR2B;HTR2A;HTR1E;HTR3A;MAOA;HTR1F
serotonin receptor activityHTR3B;HTR2A;HTR1B;HTR5AL;HTR5A;HTR4;HTR2B;HTR3C;HTR1A

HTR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR1B.

MDFI; serotonin; iodocyanopindolol/cyp; HTR1A; NME2; GSTK1

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