HTR1B
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
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Overview
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009] -
Synonyms
HTR1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB; 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Canis lupus familiaris (Dog) (Canis familiaris)
- Cavia porcellus (Guinea pig)
- Chicken
- Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
- Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
- Equus caballus (Horse)
- Felis catus (Cat) (Felis silvestris catus)
- Gorilla gorilla gorilla (Western lowland gorilla)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Oryctolagus cuniculus (Rabbit)
- Pan troglodytes (Chimpanzee)
- Rat
- Rattus norvegicus (Rat)
- Spalax ehrenbergi (Middle East blind mole rat) (Nannospalax ehrenbergi)
- Vulpes vulpes (Red fox)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In vitro E. coli expression system
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Flag,His
- GST
- His
- His (Fc)
- Avi
- Flag
- SUMO
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HTR1B-14002H | Recombinant Human HTR1B, His-tagged | E.coli | His | 228-315a.a. | |
Human | HTR1B-5337HCL | Recombinant Human HTR1B 293 Cell Lysate | HEK293 | N/A | ||
Human | HTR1B-5251H | Recombinant Human HTR1B Protein, GST-tagged | Wheat Germ | GST | ||
Human | HTR1B-1086HFL | Recombinant Human HTR1B protein, His&Flag-tagged | HEK293 | His&Flag | 1-390 aa | |
Human | HTR1B-0284H | Recombinant Human HTR1B Full Length Transmembrane protein, His-tagged | In vitro E. coli expression system | His | 1-390aa | |
Human | HTR1B-392H | Recombinant Human HTR1B Full Length Transmembrane protein, His-SUMO-tagged | In vitro E. coli expression system | His-SUMO | 1-390aa | |
Human | HTR1B-0500H | Recombinant Human HTR1B Protein (N32-I239, L138W, A306-S390 end), Flag, His tagged | Insect Cell | Flag,His | N32-I239, L138W, A306-S390 end | |
Mouse | HTR1B-7929M | Recombinant Mouse HTR1B Protein | Mammalian Cell | His | ||
Mouse | HTR1B-4372M-B | Recombinant Mouse HTR1B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | HTR1B-4372M | Recombinant Mouse HTR1B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | HTR1B-2960R | Recombinant Rat HTR1B Protein | Mammalian Cell | His | ||
Rat | HTR1B-2615R | Recombinant Rat HTR1B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | HTR1B-2615R-B | Recombinant Rat HTR1B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Canis lupus familiaris (Dog) (Canis familiaris) | RFL5380CF | Recombinant Full Length Dog 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-389) | |
Cavia porcellus (Guinea pig) | RFL17414CF | Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-389) | |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) | RFL36133CF | Recombinant Full Length Cricetulus Griseus 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-386) | |
Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana) | RFL19861DF | Recombinant Full Length Didelphis Marsupialis Virginiana 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-388) | |
Equus caballus (Horse) | RFL6214EF | Recombinant Full Length Horse 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-390) | |
Felis catus (Cat) (Felis silvestris catus) | RFL24771FF | Recombinant Full Length Cat 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-389) | |
Gorilla gorilla gorilla (Western lowland gorilla) | RFL2619GF | Recombinant Full Length Gorilla Gorilla Gorilla 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-390) | |
Homo sapiens (Human) | RFL18079HF | Recombinant Full Length Human 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-390aa) | |
Mus musculus (Mouse) | RFL22447MF | Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-386) | |
Oryctolagus cuniculus (Rabbit) | RFL25361OF | Recombinant Full Length Rabbit 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-390) | |
Pan troglodytes (Chimpanzee) | RFL856PF | Recombinant Full Length Pan Troglodytes 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-390) | |
Rattus norvegicus (Rat) | RFL32732RF | Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-386) | |
Spalax ehrenbergi (Middle East blind mole rat) (Nannospalax ehrenbergi) | RFL10501SF | Recombinant Full Length Spalax Ehrenbergi 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-386) | |
Vulpes vulpes (Red fox) | RFL4328VF | Recombinant Full Length Vulpes Vulpes 5-Hydroxytryptamine Receptor 1B(Htr1B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-389) | |
Zebrafish | HTR1B-6992Z | Recombinant Zebrafish HTR1B | Mammalian Cell | His | ||
Chicken | HTR1B-4068C | Recombinant Chicken HTR1B | Mammalian Cell | His | ||
Kit-0996 | DL-Serine Assay Kit (Fluorometric) | N/A | ||||
Kit-1350 | HTR1B U2OS β-Arrestin GPCR Assay Kit | N/A |
- Involved Pathway
- Protein Function
- Interacting Protein
- HTR1B Related Research Area
HTR1B involved in several pathways and played different roles in them. We selected most pathways HTR1B participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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cAMP signaling pathway | GLI1;FFAR2;AKT1;ARAP3;GABBR1;NFKB1;NPY1R;HTR1A;GRIA1 |
Neuroactive ligand-receptor interaction | S1PR3;PRP2;TAAR13D;PTAFR;TACR1A;GRM3;CSH1;CHRNB4;GRIK4 |
Serotonergic synapse | CYP2C50;PLA2G4A;PRKACB;GNG3;HTR3A;HTR2C;KCND2;GNAI2;HTR1B |
HTR1B has several biochemical functions, for example, drug binding, protein binding, serotonin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR1B itself. We selected most functions HTR1B had, and list some proteins which have the same functions with HTR1B. You can find most of the proteins on our site.
Function | Related Protein |
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drug binding | PDXK;CYP2D6;CNR1;DAAM2;SRP54B;CYP4B1;CHRM2;DRD3;CYP2C9 |
protein binding | ZFYVE19;MSH2;C14orf104;GIMAP7;IFI6;HSP90AA1.1;RPA2;KPNB1;TNKS2 |
serotonin binding | HTR2C;HTR1B;HTR2B;HTR2A;HTR1E;HTR3A;MAOA;HTR1F |
serotonin receptor activity | HTR3B;HTR2A;HTR1B;HTR5AL;HTR5A;HTR4;HTR2B;HTR3C;HTR1A |
HTR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR1B.
MDFI; serotonin; iodocyanopindolol/cyp; HTR1A; NME2; GSTK1
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